O-(2-cyclohexenyl)hydroxylamine | 76029-48-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-(2-cyclohexenyl)hydroxylamine
• 英文别名: O-Cyclohex-2-en-1-ylhydroxylamine
• CAS: 76029-48-6
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: LDRDISULAKPGRY-UHFFFAOYSA-N

物化性质

• 沸点：
  187.8±20.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  O-(2-cyclohexenyl)hydroxylamine 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 silver carbonate 、 三甲基乙酸 作用下， 以 乙醚 、 乙腈 为溶剂， 反应 21.0h， 生成 1-(3-hydroxy-4,5,7,8,9,9a-hexahydrobenzo[f][1,2]oxazepin-2(3H)-yl)ethanone
  参考文献：
  名称：

  Rhodium(iii)-catalyzed C–H activation/[4+3] annulation of N-phenoxyacetamides and α,β-unsaturated aldehydes: an efficient route to 1,2-oxazepines at room temperature

  摘要：

  铑催化的C-H键官能化引发了一种[4+3]环化策略，以获得1,2-噁唑环。

  DOI：

  10.1039/c4cc05485g
• 作为产物：
  描述：

  2-环己烯醇 在 一水合肼 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 生成 O-(2-cyclohexenyl)hydroxylamine
  参考文献：
  名称：

  Rhodium(iii)-catalyzed C–H activation/[4+3] annulation of N-phenoxyacetamides and α,β-unsaturated aldehydes: an efficient route to 1,2-oxazepines at room temperature

  摘要：

  铑催化的C-H键官能化引发了一种[4+3]环化策略，以获得1,2-噁唑环。

  DOI：

  10.1039/c4cc05485g

文献信息

• NOVEL VASCULAR LEAKAGEAGE INHIBITOR
  申请人：Industry-Academic Cooperation Foundation, Yonsei University

  公开号：US20140378399A1

  公开（公告）日：2014-12-25

  The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present invention inhibits the apoptosis of vascular endothelial cells, inhibits the formation of actin stress fibers induced by VEGF, and enhances the cortical actin ring structure, thereby inhibiting vascular leakage. Accordingly, the vascular leakage inhibitor of the present invention can prevent or treat various diseases caused by vascular leakage. Since the vascular leakage inhibitor of the present invention is synthesized from commercially available or easily synthesizable pregnenolones, it has remarkably superior feasibility of commercial synthesis.

  本公开涉及一种新型血管渗漏抑制剂。本发明的新型血管渗漏抑制剂抑制血管内皮细胞凋亡，抑制由VEGF诱导的肌动蛋白应激纤维的形成，并增强皮质肌动蛋白环结构，从而抑制血管渗漏。因此，本发明的血管渗漏抑制剂可以预防或治疗由血管渗漏引起的各种疾病。由于本发明的血管渗漏抑制剂是由商业可获得或易于合成的孕酮合成的，因此具有明显优越的商业合成可行性。
• N-ALKOXYAMIDES OF 6-(TRISUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS
  申请人：Eckelbarger Joseph D.

  公开号：US20100222221A1

  公开（公告）日：2010-09-02

  N-Alkoxyamides of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are selective herbicides for corn, canola and sugar beet.

  N-烷氧基吡啶甲酸和6-氨基-4-嘧啶羧酸酯是玉米、油菜和甜菜的选择性除草剂。
• N-ALKOXYAMIDES OF 6-(SUBSTITUTED PHENYL)-4-AMINOPICOLINATES AND 2-(SUBSTITUTED PHENYL)-6-AMINO-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS SELECTIVE HERBICIDES FOR CROPS
  申请人：Eckelbarger Joseph D.

  公开号：US20130324412A1

  公开（公告）日：2013-12-05

  N-Alkoxyamides of 4-aminopicolinic acids and 6-amino-4-pyrimidinecarboxylates are selective herbicides for corn, canola and sugar beet.

  N-烷氧基化的4-氨基哌啶甲酸酰胺和6-氨基-4-嘧啶羧酸酯是玉米、油菜和甜菜的选择性除草剂。
• Cephem and cepham compounds, processes for their preparation, pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0013762A2

  公开（公告）日：1980-08-06

  Cephem and Cepham compounds of the formula: wherein R1 is amino or a protected amino, R2 is hydrogen or certain substituent. R3 is hydrogen or lower alkyl, R4 is hydrogen or certain substituent, Rs is carboxy or a protected carboxy and the heavy solid line means single or double-bond and pharmaceutically acceptable salt thereof and processes for their preparation, and also an antibacterial composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. The invention also relates to the starting compounds and their preparation.

  式中的 Cephem 和 Cepham 化合物： 式中 R1 是氨基或受保护的氨基、 R2 是氢或某些取代基 R3 是氢或低级烷基、 R4 是氢或某些取代基、 Rs 是羧基或受保护的羧基 重实线表示单键或双键及其药学上可接受的盐和它们的制备工艺，以及一种抗菌组合物，其有效成分包括上述化合物与药学上可接受的、基本上无毒的载体或赋形剂。本发明还涉及起始化合物 及其制备。
• Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0027599A2

  公开（公告）日：1981-04-29

  New cephem compounds of the formula: wherein R1 is amino or a protected amino group; R2 is hydrogen, lower alkyl which may be substituted with suitable substituent(s), lower alkenyl, lower alkynyl, cyclo(lower)-alkyl, cyclo(lower)alkenyl, or O containing 5-membered heterocyclic group substituted with oxo group(s); R3 is a group of the formula: wherein X is hydrogen or carbamoyl; and R' is -COO-; or R3 is 2-lower alkyl-5-oxo-6-hydroxy-2,5-dihydro-1, 2,4-triazinylthio; and R4 is carboxy or protected carboxy, and pharmaceutically acceptable salts thereof, and process for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. The invention also relates to the inter. mediate compounds and and their preparation,

  新的 cephem 化合物式： 其中 R1 是氨基或受保护的氨基； R2 是氢、可被适当取代基取代的低级烷基、低级烯基、低级炔基、环（低）烷基、环（低）烯基或被氧代基取代的含 O 的 5 元杂环基团； R3 是式中的基团： 其中 X 是氢或氨基甲酰基；以及 R' 是 -COO-；或 R3 是 2-低级烷基-5-氧代-6-羟基-2,5-二氢-1、 2，4-三嗪硫基；以及 R4是羧基或受保护的羧基，及其药学上可接受的盐和制备方法，以及一种药物组合物，其有效成分包括上述化合物与药学上可接受的、基本上无毒的载体或赋形剂。本发明还涉及中间体化合物 和 及其制备、