3,5-bis(4-fluorobenzoyl)anisole | 150959-54-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 3,5-bis(4-fluorobenzoyl)anisole
• 英文别名: [3-(4-Fluorobenzoyl)-5-methoxyphenyl]-(4-fluorophenyl)methanone
• CAS: 150959-54-9
• 化学式: C₂₁H₁₄F₂O₃
• 分子量: 352.337
• InChiKey: BHVSCKTUCMZDIV-UHFFFAOYSA-N

物化性质

• 沸点：
  507.2±50.0 °C(Predicted)
• 密度：
  1.266±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3,5-bis(4-fluorobenzoyl)anisole 在 5percent Pd/C 氢气 、 三溴化硼 、 potassium carbonate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 46.0h， 生成 3,5-bis{4-[3,5-bis(4-fluorobenzyl)phenoxy]benzoyl}anisole
  参考文献：
  名称：

  New Accelerated Strategy for the Synthesis of Poly(Ether Ketone) Dendrons

  摘要：

  A new AB(4)-type hypermonomer with four activated aromatic fluorines was prepared and converted to hyperbranched poly(ether ketones) by nucleophilic aromatic substitution of these fluorine atoms with phenolates. The preparation and application of the AB(4) hypermonomer for the accelerated synthesis of a family of poly(ether ketone) dendrons G2-G4 in good yield are described.

  DOI：

  10.1021/jo015805j
• 作为产物：
  描述：

  5-methoxyisophthaloyl chloride 、 4-氟苯基溴化镁 以 四氢呋喃 为溶剂， 反应 1.5h， 以60%的产率得到3,5-bis(4-fluorobenzoyl)anisole
  参考文献：
  名称：

  New Accelerated Strategy for the Synthesis of Poly(Ether Ketone) Dendrons

  摘要：

  A new AB(4)-type hypermonomer with four activated aromatic fluorines was prepared and converted to hyperbranched poly(ether ketones) by nucleophilic aromatic substitution of these fluorine atoms with phenolates. The preparation and application of the AB(4) hypermonomer for the accelerated synthesis of a family of poly(ether ketone) dendrons G2-G4 in good yield are described.

  DOI：

  10.1021/jo015805j

文献信息

• New Accelerated Strategy for the Synthesis of Poly(Ether Ketone) Dendrons
  作者：Michael A. Abramov、Ramesh Shukla、David B. Amabilino、Wim Dehaen

  DOI：10.1021/jo015805j

  日期：2002.2.1

  A new AB(4)-type hypermonomer with four activated aromatic fluorines was prepared and converted to hyperbranched poly(ether ketones) by nucleophilic aromatic substitution of these fluorine atoms with phenolates. The preparation and application of the AB(4) hypermonomer for the accelerated synthesis of a family of poly(ether ketone) dendrons G2-G4 in good yield are described.