JC023 | 1120357-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: JC023
• 英文别名: N-Hexyl-2-hydroxybenzeneacetamide；N-hexyl-2-(2-hydroxyphenyl)acetamide
• CAS: 1120357-36-9
• 化学式: C₁₄H₂₁NO₂
• mdl: MFCD23151820
• 分子量: 235.326
• InChiKey: ZOMOCYQAJKJKCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  JC023 在 diborane(6) 作用下， 以 四氢呋喃 为溶剂， 生成 2-(2-Hexylamino-ethyl)-phenol
  参考文献：
  名称：

  DE1959898

  摘要：

  公开号：
• 作为产物：
  描述：

  苯并呋喃-2(3H)-酮 、 正己胺 在 2-羟基吡啶 作用下， 以 二氯甲烷 为溶剂， 以92.6%的产率得到JC023
  参考文献：
  名称：

  [EN] NOVEL COMPOUNDS AND USES THEREOF
  [FR] NOUVEAUX COMPOSÉS ET LEURS UTILISATIONS

  摘要：

  该发明涉及由通式（I）表示的化合物及其药学上可接受的盐，其中n是1到5的整数；p是0到4的整数；R1从羟基、烷氧基、硫醇基和硫醚基组成的群体中选取；R2和R3独立地是亚甲基基团或亲核试剂，但至少其中之一是亲核试剂基团；Z是氧（O）原子或硫（S）原子；T是氢或可选择取代的脂肪族基团；但当n=2时，R1不是苯基的碳-3位置上的-甲氧基，且R1不是苯基的碳-4位置上的-羟基。

  公开号：

  WO2010144055A1

文献信息

• [EN] NOVEL COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS ET LEURS UTILISATIONS
  申请人：NANYANG POLYTECHNIC

  公开号：WO2010144055A1

  公开（公告）日：2010-12-16

  The invention relates to compounds represented by the general formula (I): and pharmaceutically acceptable salts thereof, wherein n is an integer from 1 to 5; p is an integer from 0 to 4; R1 is selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, and a thioether group; R2 and R3 are independently a methylene group or a nucleophile, with the proviso that at least one of R2 and R3 is a nucleophile group; Z is an oxygen (O) atom or sulfur (S) atom; T is hydrogen or an optionally substituted aliphatic group; with the proviso that when n = 2, R1 is not -OCH3 on the carbon-3 position of the phenyl group and R1 is not -OH on the carbon-4 position of the phenyl group.

  该发明涉及由通式（I）表示的化合物及其药学上可接受的盐，其中n是1到5的整数；p是0到4的整数；R1从羟基、烷氧基、硫醇基和硫醚基组成的群体中选取；R2和R3独立地是亚甲基基团或亲核试剂，但至少其中之一是亲核试剂基团；Z是氧（O）原子或硫（S）原子；T是氢或可选择取代的脂肪族基团；但当n=2时，R1不是苯基的碳-3位置上的-甲氧基，且R1不是苯基的碳-4位置上的-羟基。
• NOVEL USES
  申请人：Richards Mark

  公开号：US20120083532A1

  公开（公告）日：2012-04-05

  The present invention relates to the use of a compound represented by the general formula (I), and pharmaceutically acceptable salts thereof, wherein: n is an integer from 2 to 5; p is an integer from 0 to 4; R1 is selected from the group consisting of a hydroxyl group, an alkoxy group, a thiol group, a thioether group, and an amino group, wherein at least two of R 1 is a hydroxyl group, a thiol group or an amino group, with the proviso that wherein n is 2, R 1 is not on the carbon-2 position and the carbon-5 position of the phenyl group; R 2 and R 3 are independently a methylene group or a nucleophile, with the proviso that at least one of R 2 and R 3 is a nucleophile group; Z is an oxygen (O) atom or sulfur (S) atom; T is hydrogen or an optionally substituted aliphatic group; in the manufacture of a medicament for treating a patient in need of cell therapy.
• US8703822B2
  申请人：——

  公开号：US8703822B2

  公开（公告）日：2014-04-22
• Fast, Acid-Free, and Selective Lactamization of Lactones in Ionic Liquids
  作者：Kristina M. Orrling、Xiongyu Wu、Francesco Russo、Mats Larhed

  DOI：10.1021/jo8015264

  日期：2008.11.7

  A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both gamma-lactams and delta-lactams were, despite the complete absence of a Bronsted acid. obtained in useful to excellent yields after only 35 min of microwave processing.
• DE1959898
  申请人：——

  公开号：——

  公开（公告）日：——