1-hexyl-1,2,3-triazole | 63777-50-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-hexyl-1,2,3-triazole
• 英文别名: 1-Hexyltriazole
• CAS: 63777-50-4
• 化学式: C₈H₁₅N₃
• 分子量: 153.227
• InChiKey: QBRMMEUVTDBRHO-UHFFFAOYSA-N

物化性质

• 沸点：
  240.0±23.0 °C(Predicted)
• 密度：
  1.00±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-hexyl-1,2,3-triazole 以 氯仿 、 水 、 乙腈 为溶剂， 生成 1-hexyl-3-methyl-1,2,3-triazolium bis(trifluoromethylsulfonyl)imide
  参考文献：
  名称：

  1-Alkyl-3-methyl-1,2,3-triazolium [NTf2] ionic liquids: synthesis and properties

  摘要：

  A series of 1-alkyl-3-methyl-1,2,3-triazolium bis(trifluoromethylsulfonyl)imide [NTf2] ionic liquids were prepared synthetically using azide-alkyne 'click' cyclization chemistry and their physicochemical and thermal properties were determined. Increasing the alkyl chain length resulted in increased viscosities and higher thermal transitions (T-g or T-m) with depressed molar conductivities. Walden plot analysis indicated that the Tonicity of 1-butyl-3-methyl-1,2,3-triazolium [NTf2] was comparable to the analogous imidazolium system and higher than the 1,2,4-triazolium equivalent. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.11.107
• 作为产物：
  描述：

  溴己烷 在 copper(l) iodide 、 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-hexyl-1,2,3-triazole
  参考文献：
  名称：

  1-Alkyl-3-methyl-1,2,3-triazolium [NTf2] ionic liquids: synthesis and properties

  摘要：

  A series of 1-alkyl-3-methyl-1,2,3-triazolium bis(trifluoromethylsulfonyl)imide [NTf2] ionic liquids were prepared synthetically using azide-alkyne 'click' cyclization chemistry and their physicochemical and thermal properties were determined. Increasing the alkyl chain length resulted in increased viscosities and higher thermal transitions (T-g or T-m) with depressed molar conductivities. Walden plot analysis indicated that the Tonicity of 1-butyl-3-methyl-1,2,3-triazolium [NTf2] was comparable to the analogous imidazolium system and higher than the 1,2,4-triazolium equivalent. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.11.107

文献信息

• An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles
  作者：Sarah J.M. Patterson、Peter R. Clark、Glynn D. Williams、Nicholas C.O. Tomkinson

  DOI：10.1016/j.tetlet.2020.152483

  日期：2020.11

  This paper details a simple and efficient 3-component synthesis of 1-substituted 1,2,3-triazoles using a primary amine, 2,2-dimethoxyacetaldehyde and tosylhydrazide. The reaction proceeds in good to excellent yields using either aliphatic or aromatic amine substrates and is tolerant of a wide range of functional groups including electron-rich and deficient aryl groups, terminal alkynes, ketones and

  本文详细介绍了一种使用伯胺，2，2-二甲氧基乙醛和甲苯磺酰肼的简单高效的1取代1,2,3-三唑的3组分合成方法。使用脂族或芳族胺底物，该反应以良好的产率进行，并且耐受多种官能团，包括富电子和不足的芳基，末端炔烃，酮和高度位阻的胺。
• Luminescent Compounds and Methods of Using Same
  申请人：Queen's University at Kingston

  公开号：US20170358761A1

  公开（公告）日：2017-12-14

  Compounds are provided that are photoluminescent and electroluminescent, and may emit intense blue or deep blue light. Also provided are methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin films, and uses of the compounds described herein in a light emitting device, a luminescent probe, a sensor, and/or an electroluminescent device.

  提供了既具有光致发光又具有电致发光特性的化合物，可能发射出强烈的蓝光或深蓝光。还提供了产生光致发光和电致发光的方法，将这些化合物应用于薄膜的方法，以及在发光器件、发光探针、传感器和/或电致发光器件中使用本文所述的化合物的用途。
• Monosubstituted 1,2,3-triazoles from two-step one-pot deprotection/click additions of trimethylsilylacetylene
  作者：James T. Fletcher、Sara E. Walz、Matthew E. Keeney

  DOI：10.1016/j.tetlet.2008.09.136

  日期：2008.12

  Two-step one-pot reaction conditions have been developed for synthesizing 1-substituted-1,2,3-triazoles. This transformation involves the base-catalyzed deprotection of trimethylsilylacetylene followed by Cu-catalyzed Huisgen 1,3-dipolar cycloaddition under aqueous reaction conditions. Utilization of potassium carbonate as the base and methanol as the alcoholic aqueous co-solvent resulted in optimal

  已经开发了两步一锅法反应条件来合成1-取代的1,2,3,3-三唑。该转化涉及在水性反应条件下，碱催化的三甲基甲硅烷基乙炔的脱保护，然后是铜催化的惠斯根1,3-偶极环加成。以碳酸钾为碱，以甲醇为醇性水性助溶剂，可得到所需产物的最佳收率。发现该反应条件对于烷基和芳基叠氮化物反应物都是成功的，包括具有给电子和吸电子功能的类似物。该方法是简单且区域选择性的方法，通过该方法可以直接从叠氮化物前体制备1-取代的1,2,3-三唑化合物。
• Luminescent compounds and methods of using same
  申请人：Queen's University at Kingston

  公开号：US10461266B2

  公开（公告）日：2019-10-29

  Compounds are provided that are photoluminescent and electroluminescent, and may emit intense blue or deep blue light. Also provided are methods of producing photoluminescence and electroluminescence, methods of applying the compounds in thin films, and uses of the compounds described herein in a light emitting device, a luminescent probe, a sensor, and/or an electroluminescent device.

  所提供的化合物具有光致发光和电致发光特性，可发出强烈的蓝色或深蓝色光。此外，还提供了产生光致发光和电致发光的方法、将化合物应用于薄膜的方法，以及本文所述化合物在发光装置、发光探针、传感器和/或电致发光装置中的用途。
• Tricyclic degraders of Ikaros and Aiolos
  申请人：C4 Therapeutics, Inc.

  公开号：US11407732B1

  公开（公告）日：2022-08-09

  Tricyclic cereblon binders for the degradation of Ikaros or Aiolos by the ubiquitin proteasome pathway for therapeutic applications are described.

  介绍了用于治疗的三环脑龙结合剂，可通过泛素蛋白酶体途径降解 Ikaros 或 Aiolos。