1-cyclopropyl-6,8-difluoro-7-<3,7-diazabicyclo<3.3.0>oct-1(5)-en-3-yl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | 135675-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-cyclopropyl-6,8-difluoro-7-<3,7-diazabicyclo<3.3.0>oct-1(5)-en-3-yl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
• 英文别名: 1-cyclopropyl-7-[3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl]-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid；1-cyclopropyl-6,8-difluoro-4-oxo-7-(2,3,4,6-tetrahydro-1H-pyrrolo[3,4-c]pyrrol-5-yl)quinoline-3-carboxylic acid
• CAS: 135675-19-3
• 化学式: C₁₉H₁₇F₂N₃O₃
• 分子量: 373.359
• InChiKey: QDUGGYAKXPEHDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  72.9
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-cyclopropyl-6,8-difluoro-7-<3,7-diazabicyclo<3.3.0>oct-1(5)-en-3-yl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 以85%的产率得到1-cyclopropyl-7-[3,7-diazabicyclo[3.3.0] oct-1(5)-en-3-yl]-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid formic acid salt
  参考文献：
  名称：

  Quinolone compounds and a process for their preparation

  摘要：

  通式喹诺酮化合物的药物组合物对抗细菌感染具有活性，包含这种化合物，制造喹诺酮化合物和组合物的过程以及利用喹诺酮化合物制造用于治疗细菌感染的药物组合物。

  公开号：

  EP0424850A1
• 作为产物：
  描述：

  1-环丙基-6,7,8-三氟-4-氧代-1,4-二氢喹啉-3-羧酸 、 1,2,3,4,5,6-hexahydropyrrolo[3,4-c]pyrrole dihydrobromide 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以89%的产率得到1-cyclopropyl-6,8-difluoro-7-<3,7-diazabicyclo<3.3.0>oct-1(5)-en-3-yl>-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
  参考文献：
  名称：

  Synthesis of 1,2,3,4,5,6-Hexahydropyrrolo[3,4-c]pyrrole Dihydrobromide and 1,2,3,5-Tetrahydro-2-[(4-methylphenyl)sulfonyl]pyrrolo[3,4-c]pyrrole

  摘要：

  Synthesis of the pyrrolo[3,4-c] pyrrole derivatives (8) and (9) is reported. Nucleophilic aromatic substitution of the 7-fluoride of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (1) by 8 under basic conditions followed by N-methylation, gives the quinolone antibacterial agent (11) (KR 10755, HK 3140).

  DOI：

  10.3987/com-95-7061

文献信息

• Quinolone compounds and a process for their preparation
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0424850A1

  公开（公告）日：1991-05-02

  Quinolone compounds of the general formula pharmaceutical compositions active against bacterial infections containing such compounds, processes for the manufacture of the quinolone compounds and the compositions and the use of the quinolone compounds for the manufacture of pharmaceutical compositions for the treatment of bacterial infections.

  通式喹诺酮化合物的药物组合物对抗细菌感染具有活性，包含这种化合物，制造喹诺酮化合物和组合物的过程以及利用喹诺酮化合物制造用于治疗细菌感染的药物组合物。
• Diazabicyclo amine compounds which are intermediates for anti-bacterial
  申请人：Korea Research Institute of Chemical Technology

  公开号：US05089621A1

  公开（公告）日：1992-02-18

  Diazabicycloamine compounds of the general formula I and their acid salts ##STR1## wherein m represents an integer of 1 to 3, n represents 1 or 2, and R.sub.1 or R.sub.2 represents hydrogen or lower alkyl group, a process for their manufacture and their use for the preparation of novel quinolone compounds having excellent antibacterial activity.

  一般式I的二氮杂双环胺化合物及其酸盐，其中m表示1至3的整数，n表示1或2，R.sub.1或R.sub.2表示氢或较低的烷基基团，一种其制备方法以及用于制备具有优异抗菌活性的新奎诺酮化合物的用途。
• Diazabicycloamine compounds and a process for their preparation
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0424852A1

  公开（公告）日：1991-05-02

  Diazabicycloamine compounds of the general formula I and their acid salts wherein m represents an integer of 1 to 3, n represents 1 or 2, and R₁ or R₂ represents hydrogen or lower alkyl group, a process for their manufature and their use for the preparation of novel quinolone compounds having excellent antibacterial activity.

  Diazabicycloamine化合物的一般公式I及其酸盐，其中m代表1到3的整数，n代表1或2，而R₁或R₂代表氢或较低的烷基基团，一种其制备方法以及它们用于制备具有优良抗菌活性的新奎诺酮化合物。
• JPH03193780A
  申请人：——

  公开号：JPH03193780A

  公开（公告）日：1991-08-23
• US5089621A
  申请人：——

  公开号：US5089621A

  公开（公告）日：1992-02-18