(R)-(+)-4-ethyl-2-(2-quinolinyl)oxazoline | 137488-67-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (R)-(+)-4-ethyl-2-(2-quinolinyl)oxazoline
• CAS: 137488-67-6
• 化学式: C₁₄H₁₄N₂O
• 分子量: 226.278
• InChiKey: YYWBQFUCBDPSTB-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  17.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  34.48
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  喹哪啶酸 在 氯化亚砜 、 三乙胺 作用下， 反应 14.0h， 生成 (R)-(+)-4-ethyl-2-(2-quinolinyl)oxazoline
  参考文献：
  名称：

  Enantioselective catalysis 74.

  摘要：

  The enantioselective hydrosilylation of acetophenone and diphenylsilane with [Rh(COD)Cl2] and the cocatalysts L1 - L4 was investigated. The substitution of hydrogen in the 6-position of the pyridine ring dramatically reduces the dependence of the optical induction on ligand excess, solvent, and concentration of diphenylsilane, acetophenone, and catalyst. The 6-substituents on the pyridine ring are assumed to block one of the coordination sites of rhodium, preventing further interaction with additional ligands, solvents, substrates, and additives.

  DOI：

  10.1016/s0957-4166(00)82204-1

文献信息

• Enantioselective catalysis 74.
  作者：Henri Brunner、Paul Brandl

  DOI：10.1016/s0957-4166(00)82204-1

  日期：1991.1

  The enantioselective hydrosilylation of acetophenone and diphenylsilane with [Rh(COD)Cl2] and the cocatalysts L1 - L4 was investigated. The substitution of hydrogen in the 6-position of the pyridine ring dramatically reduces the dependence of the optical induction on ligand excess, solvent, and concentration of diphenylsilane, acetophenone, and catalyst. The 6-substituents on the pyridine ring are assumed to block one of the coordination sites of rhodium, preventing further interaction with additional ligands, solvents, substrates, and additives.