MAZ1702 | 29900-78-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: MAZ1702
• 英文别名: (Z)-2-fluoro-N-hydroxy-3-phenylprop-2-enamide
• CAS: 29900-78-5
• 化学式: C₉H₈FNO₂
• 分子量: 181.166
• InChiKey: FZUOLXLHHNWWBL-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl (2Z)-3-fluoro-3-phenylprop-2-enoate 在 氢氧化钾 、 盐酸羟胺 作用下， 以 甲醇 为溶剂， 生成 MAZ1702
  参考文献：
  名称：

  Dessolin,M. et al., Bulletin de la Societe Chimique de France, 1970, p. 2573 - 2580

  摘要：

  DOI：

文献信息

• FLUORINATED HDAC INHIBITORS AND USES THEREOF
  申请人：Bradner James Elliot

  公开号：US20130040998A1

  公开（公告）日：2013-02-14

  Fluorinated deacetylase inhibitors of the general formulae (I), (II), and (III): and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase activity as described herein (e.g., cancer, neurodegenerative diseases, inflammatory diseases).
• [EN] FLUORINATED HDAC INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS FLUORÉS DE HDAC ET LEURS UTILISATIONS
  申请人：HARVARD COLLEGE

  公开号：WO2011084991A2

  公开（公告）日：2011-07-14

  Fluorinated deacetylase inhibitors of the general formulae (I), (II), and (III): and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and thus are useful for the treatment of various diseases and disorders associated with acetylase activity as described herein (e.g., cancer, neurodegenerative diseases, inflammatory diseases).
• Dessolin,M. et al., Bulletin de la Societe Chimique de France, 1970, p. 2573 - 2580
  作者：Dessolin,M. et al.

  DOI：——

  日期：——