2-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimide | 327602-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimide
• 英文别名: 1-methyl-3-(1-methylindol-3-yl)-4-phenylpyrrole-2,5-dione
• CAS: 327602-10-8
• 化学式: C₂₀H₁₆N₂O₂
• 分子量: 316.359
• InChiKey: GOTGNXWHPGOOPV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  42.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimide 在 palladium-carbon 氢气 、 palladium-carbon 、 silica gel 、 乙酸乙酯 、 正己烷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 以to obtain 1-methyl-3-(1-methyl-1H-indol-3-yl)-2,5-dioxo-4-phenylpyrrolidine (97.3 mg, 96.7%) as pale yellow solids的产率得到1-methyl-3-(1-methyl-1H-indol-3-yl)-2,5-dioxo-4-phenylpyrrolidine
  参考文献：
  名称：

  Indolylpyrrole derivatives and cell death inhibitors

  摘要：

  本发明提供一种化合物，其化学式表示为(I)，用于抑制细胞死亡，该药物预期可作为预防或治疗各种细胞死亡参与进展和恶化的疾病的药物：1和细胞死亡抑制剂，细胞、器官或组织或细胞的药物或保护剂，每种药物均包含衍生物作为活性成分。

  公开号：

  US20030087949A1
• 作为产物：
  描述：

  1-甲基吲哚-3-乙酰胺 在 potassium tert-butylate 、 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(1-methyl-1H-indol-3-yl)-3-phenyl-N-methylmaleimide
  参考文献：
  名称：

  Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives

  摘要：

  Novel analogs of indolylmaleimide derivatives (IM derivatives) were synthesized and tested for cell death-inhibitory activity. 2-(1H-Indol-3-yl)-3-pentylamino-maleimide IM-54 was the most effective cell death inhibitor among the compounds tested. IM-54 inhibited necrotic cell death induced by H2O2, but not apoptotic cell death induced by etoposide. These results indicated that this novel cell death inhibitor is distinct from the well-known caspase inhibitor, Z-VAD, which can block apoptotic cell death, but not necrotic cell death. IM-54 is expected to be a powerful bioprobe for clarifying the unique signaling pathway of necrotic cell death. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.016

文献信息

• Electrolyte composition and electrochemical battery using the same
  申请人：——

  公开号：US20020055046A1

  公开（公告）日：2002-05-09

  An electrolyte composition which is excellent in durability and charge transport performance, and an electrochemical battery in which deterioration of the charge transport performance with time is minimized, the electrolyte composition including therein a salt which comprises an anion which contains a mesogen group, and an alkyl or alkenyl group having 6 carbons or more in the structure of the anion, and an organic or inorganic cation.

  一种电解质组成物，其耐久性和电荷传输性能优异，以及一种电化学电池，其中时间内电荷传输性能的恶化被最小化，该电解质组成物包括一种盐，其包含一种含有介质基团的阴离子，并且在阴离子的结构中具有6个或更多碳的烷基或烯基基团，以及一种有机或无机阳离子。
• INDOLYLPYRROLE DERIVATIVES AND CELL DEATH INHIBITORS
  申请人：SAGAMI CHEMICAL RESEARCH CENTER

  公开号：EP1275646A1

  公开（公告）日：2003-01-15

  The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exacerbation thereof: and, a cell death inhibitor, a drug or a preservative for cells, organs or tissues or cells, each comprising the derivative as an active ingredient.

  本发明提供了一种由下式(I)代表的化合物，该化合物可用于抑制细胞死亡，该药物可望作为各种疾病的预防或治疗药物，在这些疾病中，细胞死亡参与了疾病的进展和恶化： 以及细胞死亡抑制剂、细胞、器官或组织或细胞的药物或防腐剂，每一种都包含该衍生物作为活性成分。
• Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives
  作者：Kosuke Dodo、Miho Katoh、Tadashi Shimizu、Masahiro Takahashi、Mikiko Sodeoka

  DOI：10.1016/j.bmcl.2005.04.016

  日期：2005.6

  Novel analogs of indolylmaleimide derivatives (IM derivatives) were synthesized and tested for cell death-inhibitory activity. 2-(1H-Indol-3-yl)-3-pentylamino-maleimide IM-54 was the most effective cell death inhibitor among the compounds tested. IM-54 inhibited necrotic cell death induced by H2O2, but not apoptotic cell death induced by etoposide. These results indicated that this novel cell death inhibitor is distinct from the well-known caspase inhibitor, Z-VAD, which can block apoptotic cell death, but not necrotic cell death. IM-54 is expected to be a powerful bioprobe for clarifying the unique signaling pathway of necrotic cell death. (c) 2005 Elsevier Ltd. All rights reserved.
• Indolylpyrrole derivatives and cell death inhibitors
  申请人：——

  公开号：US20030087949A1

  公开（公告）日：2003-05-08

  The invention provides a compound represented by the following formula (I) useful for inhibiting death of cells, the drug being expected as a preventive or a remedy for the progress of various diseases wherein cell death participates in progress and exacerbation thereof: 1 and, a cell death inhibitor, a drug or a preservative for cells, organs or tissues or cells, each comprising the derivative as an active ingredient.

  本发明提供了一种化合物，其化学式表示为(I)，可用于抑制细胞死亡。该药物预期可作为预防或治疗各种细胞死亡参与病程和恶化的疾病的药物，同时还提供了一种细胞死亡抑制剂、细胞、器官或组织的药物或保护剂，每种药物均包含该衍生物作为活性成分。