dimethyl 3-methylenecyclopropane-1,2-dicarboxylate | 55281-54-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl 3-methylenecyclopropane-1,2-dicarboxylate
• 英文别名: methylene-cyclopropane-1,2-dicarboxylic acid dimethyl ester；Inakt. 2-Methyl-cyclopropen-(1)-dicarbonsaeure-(1.3)-dimethylester；Methylen-cyclopropan-1,2-dicarbonsaeure-dimethylester；3-methylene-1,2-cyclopropanedicarboxylic acid,dimethyl ester；dimethyl 3-methylene-1,2-cyclopropane dicarboxylate；3-Methylen-cyclopropan-1,2-dicarbonsaeuremethylester；Dimethyl 3-methylidenecyclopropane-1,2-dicarboxylate
• CAS: 55281-54-4
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: BBYRCAPYYSBUQL-UHFFFAOYSA-N

物化性质

• 沸点：
  223.7±40.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  dimethyl 3-methylenecyclopropane-1,2-dicarboxylate 在 咪唑 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 18-冠醚-6 、 四丁基氟化铵 、 potassium carbonate 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.5h， 生成 [(1R,2R)-2-(6-Chloro-purin-9-ylmethyl)-3-methylene-cyclopropyl]-methanol
  参考文献：
  名称：

  SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL EXOMETHYLENE CYCLOPROPYL NUCLEOSIDES

  摘要：

  Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5, prepared from Feist's acid 1 was condensed with purine derivatives by the S(N)2 type reaction. All the synthesized compounds were evaluated for antiviral activity.

  DOI：

  10.1081/ncn-100002491
• 作为产物：
  描述：

  甲醇 、 Feist's acid 在 硫酸 作用下， 反应 18.0h， 以96%的产率得到dimethyl 3-methylenecyclopropane-1,2-dicarboxylate
  参考文献：
  名称：

  SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL EXOMETHYLENE CYCLOPROPYL NUCLEOSIDES

  摘要：

  Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5, prepared from Feist's acid 1 was condensed with purine derivatives by the S(N)2 type reaction. All the synthesized compounds were evaluated for antiviral activity.

  DOI：

  10.1081/ncn-100002491

文献信息

• A Radical Bidirectional Fragment Coupling Route to Unsymmetrical Ketones
  作者：Lucile Anthore-Dalion、Qiang Liu、Samir Z. Zard

  DOI：10.1021/jacs.6b05344

  日期：2016.7.13

  A powerful strategy for the regioselective bidirectional synthesis of unsymmetrically substituted ketones is described, relying on the fact that the exchange of a xanthate is much faster than the radical addition to an unactivated alkene. The use of an alkene as the formal "alkylating" agent associated with the tolerance for numerous functional groups and the mildness of the experimental conditions

  描述了不对称取代酮的区域选择性双向合成的强大策略，依赖于黄药的交换比未活化烯烃的自由基加成快得多的事实。使用烯烃作为正式的“烷基化”剂，与许多官能团的耐受性和实验条件的温和性相关，消除了与经典离子和过渡金属方法相关的许多问题。
• ORGANORUTHENIUM CARBIDE COMPLEXES AS PRECATALYSTS FOR OLEFIN METATHESIS
  申请人：APEIRON SYNTHESIS S. A.

  公开号：US20210077988A1

  公开（公告）日：2021-03-18

  Embodiments in accordance with the present invention encompass an organoruthenium compound of the formula (I) or formula (II): Wherein X, L, R 1 , R 2 , R 3 , R 4 , R 5 , Ar 1 and Ar 2 are as defined herein. Also disclosed herein are the use of organoruthenium compound of the formula (I) or formula (II) as (pre)catalysts for the olefin metathesis reactions, as well as to the process for carrying out the olefin metathesis reaction.

  根据本发明的实施例，涵盖了符合以下公式(I)或公式(II)的有机钌化合物： 其中X、L、R1、R2、R3、R4、R5、Ar1和Ar2如本文所定义。本文还披露了将公式(I)或公式(II)的有机钌化合物用作烯烃转化反应的(前)催化剂，以及进行烯烃转化反应的方法。
• Oxidation of reaction products of p-aryl-С,С-disubstituted nitrones and dimethyl 3-methylenecyclopropane-1,2-dicarboxylate
  作者：A. P. Molchanov、T. Q. Tran、A. V. Stepakov、R. R. Kostikov

  DOI：10.1134/s1070428016110099

  日期：2016.11

  Oxidation with 2,3-dichloro-4,5-dicyanobenzoquinone of 2,4-dihydro-1Н-azeto[1,2-a]quinoline-3,4 -dicarboxylates obtained in the reaction of N-aryl-С,С-disubstituted nitrones with Feist’s acid ester resulted in the formation of 2-vinylquinoline-3,4-dicarboxylates in good yields.

  氧化与2,4-二氢-1-的2,3-二氯-4,5-二氰基苯醌Н -azeto [1,2一]喹啉-3,4-中的反应获得-dicarboxylates Ñ -芳基- С，С Feist酸酯形成的-di取代的硝基化合物以良好的收率形成了2-vinylquinoline-3,4-dicarboxylates。
• ANTHRAQUINONE PIGMENT, OCULAR LENS MATERIAL USING SAME, OCULAR LENS MATERIAL MANUFACTURING METHOD, AND OCULAR LENS
  申请人：Menicon Co., Ltd.

  公开号：EP2514791A1

  公开（公告）日：2012-10-24

  Provided by the present invention are an anthraquinone colorant for coloring an ophthalmic lens represented by the following general formula (1): and a high molecular anthraquinone colorant obtained by forming a covalent bond between the anthraquinone colorant and a monomer for an ophthalmic lens. The monomer for an ophthalmic lens preferably has a polydimethylsiloxane structure. Further provided by the present invention is an ophthalmic lens material formed from a composition containing the colorant and a monomer for an ophthalmic lens having an unsaturated double bond, and the lens material containing a polymer comprising the monomer for an ophthalmic lens as a monomer unit.

  本发明提供了一种用于给眼科镜片着色的蒽醌着色剂，由以下通式（1）表示： 和一种高分子蒽醌着色剂，通过在蒽醌着色剂和眼科镜片用单体之间形成共价键而获得。眼科镜片用单体最好具有聚二甲基硅氧烷结构。本发明还提供了一种眼科镜片材料，该材料由含有着色剂和具有不饱和双键的眼科镜片用单体的组合物形成，且镜片材料含有以眼科镜片用单体为单体单元的聚合物。
• Organoruthenium carbide complexes as precatalysts for olefin metathesis
  申请人：APEIRON SYNTHESIS S. A.

  公开号：US11291983B2

  公开（公告）日：2022-04-05

  Embodiments in accordance with the present invention encompass an organoruthenium compound of the formula (I) or formula (II): Wherein X, L, R1, R2, R3, R4, R5, Ar1 and Ar2 are as defined herein. Also disclosed herein are the use of organoruthenium compound of the formula (I) or formula (II) as (pre)catalysts for the olefin metathesis reactions, as well as to the process for carrying out the olefin metathesis reaction.

  本发明的实施方案包括式（I）或式（II）的有机钌化合物： 其中 X、L、R1、R2、R3、R4、R5、Ar1 和 Ar2 如本文所定义。本文还公开了式 (I) 或式 (II) 有机钌化合物作为烯烃偏析反应（前）催化剂的用途，以及进行烯烃偏析反应的工艺。