Feist's acid | 45786-15-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Feist's acid
• 英文别名: (trans)-3-methylene-1,2-cyclopropanedicarboxylic acid；3-Methylene-1,2-cyclopropanecarboxylic acid；3-Methylidenecyclopropane-1,2-dicarboxylic acid
• CAS: 45786-15-0
• 化学式: C₆H₆O₄
• mdl: MFCD00066746
• 分子量: 142.111
• InChiKey: XZVHROKAQFFOCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Feist's acid 、 quinine 生成 (+)-Feist's acid
  参考文献：
  名称：

  HSIAO, CHI-NUNG;HANNICK, STEVEN M., TETRAHEDRON LETT., 31,(1990) N6, C. 6609-6612

  摘要：

  DOI：

文献信息

• Process and intermediates for the preparation of an antiviral agent containing a cyclobutyl group
  申请人：E.R. SQUIBB & SONS, INC.

  公开号：EP0535448A2

  公开（公告）日：1993-04-07

  Racemic Feist's acid is treated with (R)-(+)-a-methylbenzylamine to yield (1R-trans)-3-methylenecyclopropane-1,2-dicarboxylic acid, (R)-a-methylbenzylamine (1:1) salt. This salt can then be converted to (1R-trans)-3-methylene-1,2-cyclopropanedicarboxylic acid, dimethyl ester which is an intermediate in the preparation of the antiviral agent Ä1R-(1a,2b,3a)Ü-2-amino-9-Ä2,3-bis(hydroxymethyl)cyclobutylÜ-1,9-dihydro-6H-purin-6-one. The improved process also enables the recovery of racemic Feist's acid from the resolution.

  混合型的费斯特酸经过(R)-(+)-α-甲基苄胺的处理，生成(1R-trans)-3-亚甲基环丙烷-1,2-二羧酸，与(R)-α-甲基苄胺(1:1)盐。该盐可转化为(1R-trans)-3-亚甲基-1,2-环丙烷二羧酸，二甲酯，该中间体用于制备抗病毒剂Ä1R-(1a,2b,3a)Ü-2-氨基-9-Ä2,3-双(羟甲基)环丁基Ü-1,9-二氢-6H-嘌呤-6-酮。改进的工艺还能使费斯特酸从分离中恢复。
• HEAT CARRIER COMPOSITION
  申请人：Shishiai-Kabushikigaisha

  公开号：EP1698678A1

  公开（公告）日：2006-09-06

  The present invention relates to a heat transfer medium composition which contains water, a glycol, alcohol and/or glycol ether as a main ingredient and a pH buffering agent. The composition provides improved and long lasting buffering in actual use to maintain the pH value of the medium within the appropriate range of pH 6 to pH 10. The pH buffering agent is prepared of an alicyclic compound where two members selected from among carboxyl and its salts are bonded to a ring-constituting carbon atom, or at least two members selected from the group are respectively bonded to as many neighboring carbon atoms. Alternatively, the pH buffering agent is prepared of a heterocyclic compound in which at least one ring-constituting carbon atom of the alicyclic compound is substituted by a nitrogen or oxygen atom, where two members selected from the group are bonded to a ring-constituting carbon atom, or at least two members selected from the group are respectively bonded to as many neighboring carbon atoms.

  本发明涉及一种导热介质组合物，其主要成分包括水、乙二醇、醇和/或乙二醇醚以及 pH 缓冲剂。在实际使用中，该组合物具有更好的持久缓冲作用，可将介质的 pH 值保持在 pH 6 至 pH 10 的适当范围内。pH 缓冲剂是由脂环族化合物制备的，其中从羧基及其盐类中选出的两个成员键合到一个构成环的碳原子上，或者从该基团中选出的至少两个成员分别键合到尽可能多的相邻碳原子上。或者，pH 缓冲剂由杂环化合物制备而成，其中脂环族化合物的至少一个构环碳原子被氮原子或氧原子取代，从该组中选出的两个成员与一个构环碳原子键合，或从该组中选出的至少两个成员分别与相邻的多个碳原子键合。
• PHOSPHOLIPID DERIVATIVE AND PH-RESPONSIVE LIPOSOMES
  申请人：NOF Corporation

  公开号：EP2500348A1

  公开（公告）日：2012-09-19

  A phospholipid derivative represented by the following formula (1) wherein each symbol is as described in the specification; a liposome containing the phospholipid derivative, and the like.

  下式（1）所代表的磷脂衍生物 其中各符号如说明书所述；含有该磷脂衍生物的脂质体等。
• Nguyen, SonBinh T.; Grubbs, Robert H.; Ziller, Joseph W., Journal of the American Chemical Society, 1995, vol. 117, p. 5503 - 5511
  作者：Nguyen, SonBinh T.、Grubbs, Robert H.、Ziller, Joseph W.

  DOI：——

  日期：——
• SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL EXOMETHYLENE CYCLOPROPYL NUCLEOSIDES
  作者：Bo Gil Choi、Eun Yee Kwak、Joon Hee Hong、Chong Kyo Lee

  DOI：10.1081/ncn-100002491

  日期：2001.3.31

  Novel cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5, prepared from Feist's acid 1 was condensed with purine derivatives by the S(N)2 type reaction. All the synthesized compounds were evaluated for antiviral activity.

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