1-Butyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4-one | 1263189-27-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Butyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4-one
• CAS: 1263189-27-0
• 化学式: C₂₄H₂₇NO₃
• 分子量: 377.483
• InChiKey: JPJDXGMXFBFGTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二甲基溴苯 在 氯化亚砜 、 potassium carbonate 、 三乙胺 作用下， 以 甲醇 、 二氯甲烷 、 丙酮 为溶剂， 反应 20.0h， 生成 1-Butyl-5-(2,4-dimethylphenoxy)-2-(phenoxymethyl)pyridin-4-one
  参考文献：
  名称：

  Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent

  摘要：

  We report the discovery, synthesis, and biological activities of phenoxy-4-pyrone and phenoxy-4-pyridone derivatives as novel inhibitors of enoyl-acyl carrier protein reductase (FabI). Pyridone derivatives showed better activities than pyrone derivatives against FabI and Staphylococcus aureus strains, including methicillin-resistant Staphylococcus aureus (MRSA). Among the pyridone derivatives, compound 16l especially exhibited promising activities against the MRSA strain and good pharmacokinetic profiles. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.08.077

文献信息

• [EN] NOVEL 3-PHENOXY-4-PYRONE, 3-PHENOXY-4-PYRIDONE, OR 4-PYRIDONE DERIVATIVES, METHOD FOR PREPARING SAME, AND ANTIMICROBIAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT<br/>[FR] NOUVEAUX DÉRIVÉS DE 3-PHÉNOXY-4-PYRONE, DE 3-PHÉNOXY-4-PYRIDONE, OU DE 4-PYRIDONE, PROCÉDÉ D'ÉLABORATION CORRESPONDANT, ET COMPOSITION ANTIMICROBIENNE CONTENANT DE TELS DÉRIVÉS COMME PRINCIPES ACTIFS
  申请人：KOREA INST SCI & TECH

  公开号：WO2011014008A2

  公开（公告）日：2011-02-03

  본 발명은 신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체, 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 항균 조성물에 관한 것으로, 본 발명에 따른 신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체를 함유하는 조성물은 박테리아 지방산 생합성 효소인 에노일-ACP 환원효소(FabI)를 효과적으로 억제하므로 항균제로서 유용하게 사용될 수 있다.
• Discovery of a potent enoyl-acyl carrier protein reductase (FabI) inhibitor suitable for antistaphylococcal agent
  作者：Yun Gyeong Kim、Jae Hong Seo、Jin Hwan Kwak、Kye Jung Shin

  DOI：10.1016/j.bmcl.2015.08.077

  日期：2015.10

  We report the discovery, synthesis, and biological activities of phenoxy-4-pyrone and phenoxy-4-pyridone derivatives as novel inhibitors of enoyl-acyl carrier protein reductase (FabI). Pyridone derivatives showed better activities than pyrone derivatives against FabI and Staphylococcus aureus strains, including methicillin-resistant Staphylococcus aureus (MRSA). Among the pyridone derivatives, compound 16l especially exhibited promising activities against the MRSA strain and good pharmacokinetic profiles. (C) 2015 Elsevier Ltd. All rights reserved.