6-chloro-2-methoxy-9-(3'-diethylamino methyl-4'-hydroxyanilino)acridine | 114277-11-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-2-methoxy-9-(3'-diethylamino methyl-4'-hydroxyanilino)acridine
• 英文别名: amodiaquine-mepacrine；PH001924；4-(6-chloro-2-methoxy-acridin-9-ylamino)-2-diethylaminomethyl-phenol；4-(6-Chlor-2-methoxy-acridin-9-ylamino)-2-diaethylaminomethyl-phenol；6-Chlor-9-(4-hydroxy-3-diethylaminomethyl-anilino)-2-methoxy-acridin；4-[(6-Chloro-2-methoxy-acridin-9-yl)amino]-2-(diethylaminomethyl)phenol；4-[(6-chloro-2-methoxyacridin-9-yl)amino]-2-(diethylaminomethyl)phenol
• CAS: 114277-11-1
• 化学式: C₂₅H₂₆ClN₃O₂
• 分子量: 435.953
• InChiKey: GICKTUQFXCPPNY-UHFFFAOYSA-N

物化性质

• 熔点：
  174-175 °C
• 沸点：
  558.7±50.0 °C(predicted)
• 密度：
  1.278±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  57.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-乙酰胺-2-二乙氨甲基苯酚 在 盐酸 、 水 作用下， 生成 6-chloro-2-methoxy-9-(3'-diethylamino methyl-4'-hydroxyanilino)acridine
  参考文献：
  名称：

  氨基烷基酚作为抗疟药（杂环氨基）-α-氨基-邻甲酚；迷彩的合成。

  摘要：

  DOI：

  10.1021/ja01184a023

文献信息

• Stawrowskaja, Zhurnal Obshchei Khimii, 1955, vol. 25, p. 193,197;engl.Ausg.S.177,180
  作者：Stawrowskaja

  DOI：——

  日期：——
• ACTIVATION OR REACTIVATION OF ACHE
  申请人：Stojanovic Milan

  公开号：US20160031854A1

  公开（公告）日：2016-02-04

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• [EN] ACTIVATION OR REACTIVATION OF ACHE<br/>[FR] ACTIVATION OU RÉACTIVATION DE L'ACHE
  申请人：UNIV COLUMBIA

  公开号：WO2014210168A1

  公开（公告）日：2014-12-31

  Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
• Aminoalkylphenols as Antimalarials. II.¹ (Heterocyclic-amino)-α-amino-o-cresols. The Synthesis of Camoquin²
  作者：J. H. Burckhalter、F. H. Tendick、Eldon M. Jones、Patricia A. Jones、W. F. Holcomb、A. L. Rawlins

  DOI：10.1021/ja01184a023

  日期：1948.4