3,11-dimethylene-1,9-dioxa-dispiro[4.2.4.2]tetradecane-2,10-dione | 74513-12-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3,11-dimethylene-1,9-dioxa-dispiro[4.2.4.2]tetradecane-2,10-dione
• 英文别名: 3,11-Dimethylidene-1,9-dioxadispiro[4.2.4~8~.2~5~]tetradecane-2,10-dione；2,10-dimethylidene-4,12-dioxadispiro[4.2.48.25]tetradecane-3,11-dione
• CAS: 74513-12-5
• 化学式: C₁₄H₁₆O₄
• 分子量: 248.279
• InChiKey: ZFWFRBDYZFOLQP-UHFFFAOYSA-N

物化性质

• 沸点：
  504.4±50.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,4-环己二酮 、 2-溴甲基丙烯酸乙酯 在 锌 作用下， 以 四氢呋喃 为溶剂， 以33%的产率得到3,11-dimethylene-1,9-dioxa-dispiro[4.2.4.2]tetradecane-2,10-dione
  参考文献：
  名称：

  Synthesis of .alpha.-methylene-.gamma.-butyrolactones: a structure-activity relationship study of their allergenic power

  摘要：

  Thirty-five alpha-methylene-gamma-butyrolactones have been prepared and their allergenic properties tested on the skin of guinea pigs experimentally sensitized to (a) alantolactone (1), (b) isoalantolactone (2), and (c) alpha-methylene-gamma-butyrolactone (3). The two first groups of animals cross-react to lactones containing 9 to 18 carbon atoms but not to smaller alpha-methylene-gamma-butyrolactones. Conversely, animals sensitized to alpha-methylene-gamma-butyrolactone react only with alpha-methylene-gamma-butyrolactones containing 6 and 7 carbon atoms. These results are discussed in relation with the allergic contact dermatitis mechanism.

  DOI：

  10.1021/jm00183a013

文献信息

• RADIATION-SENSITIVE RESIN COMPOSITION, POLYMER AND COMPOUND
  申请人：JSR Corporation

  公开号：US20130216951A1

  公开（公告）日：2013-08-22

  A radiation-sensitive resin composition includes a polymer, an acid generating agent, and an organic solvent. The polymer includes a first structural unit derived from a compound represented by a formula (1), and a second structural unit derived from a compound represented by a formula (2). R 1 represents an organic group having a valency of (a+2) that represents a ring structure having 3 to 8 carbon atoms together with the carbon atom constituting a lactone ring. R 2 represents a fluorine atom, a hydroxyl group, an organic group having 1 to 20 carbon atoms or the like.

  一种辐射敏感的树脂组合物，包括聚合物、产生酸的剂和有机溶剂。聚合物包括从公式（1）表示的化合物衍生的第一结构单元和从公式（2）表示的化合物衍生的第二结构单元。R1代表具有价数为（a+2）的有机基团，该有机基团与构成内酯环的碳原子一起形成具有3到8个碳原子的环结构。R2代表氟原子、羟基、具有1到20个碳原子的有机基团或类似物。
• RADIATION-SENSITIVE RESIN COMPOSITION, POLYMER, AND COMPOUND
  申请人：JSR Corporation

  公开号：EP2623558A1

  公开（公告）日：2013-08-07

  A radiation-sensitive resin composition includes: a polymer having a first structural unit derived from a compound represented by a formula (1), and a second structural unit derived from a compound represented by a formula (2); an acid generator; and an organic solvent. In the formula (1), R1 represents a ring structure having 3 to 8 carbon atoms taken together with a carbon atom constituting a lactone ring; R2 represents a fluorine atom, a hydroxyl group or an organic group having 1 to 20 carbon atoms; and a is an integer of 0 to 6. In a case where a is 2 or greater, a plurality of R2s are identical or different, or represent a ring structure taken together with each other. At least one group of R1 and R2 has a hetero atom or a halogen atom.

  一种辐射敏感树脂组合物包括：一种聚合物，其第一结构单元由式（1）表示的化合物衍生而来，第二结构单元由式（2）表示的化合物衍生而来；一种酸发生器；以及一种有机溶剂。在式 (1) 中，R1 代表具有 3 至 8 个碳原子的环结构，与一个碳原子一起构成内酯环；R2 代表氟原子、羟基或具有 1 至 20 个碳原子的有机基团；a 为 0 至 6 的整数。在 a 为 2 或更大的情况下，多个 R2 相同或不同，或彼此代表一个环结构。R1 和 R2 中至少有一个基团具有杂原子或卤原子。
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