4-Aminomethyl-2,5-diphenyloxazole | 90011-96-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Aminomethyl-2,5-diphenyloxazole
• 英文别名: (2,5-diphenyl-1,3-oxazol-4-yl)methanamine
• CAS: 90011-96-4
• 化学式: C₁₆H₁₄N₂O
• 分子量: 250.3
• InChiKey: BQNZBWQDZIIJKC-UHFFFAOYSA-N

物化性质

• 沸点：
  455.4±47.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 4-Aminomethyl-2,5-diphenyloxazole 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以89%的产率得到N-[(2,5-diphenyl-1,3-oxazol-4-yl)methyl]acetamide
  参考文献：
  名称：

  Synthesis and scintillating efficiencies of 4-functionalised-2,5-diphenyloxazoles

  摘要：

  A series of 4-functionalised-2,5-diphenyloxazoles has been synthesised. Each member of the series has been assessed for the ability to scintillate in the presence of ionising radiation. The scintillation counting efficiency of each member of the series has been determined relative to 2,5-diphenyloxazole, a widely used scintillant molecule. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10435-x
• 作为产物：
  描述：

  4-bromomethyl-2,5-diphenyloxazole 在 palladium on activated charcoal sodium azide 、 氢气 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 4-Aminomethyl-2,5-diphenyloxazole
  参考文献：
  名称：

  Synthesis and scintillating efficiencies of 4-functionalised-2,5-diphenyloxazoles

  摘要：

  A series of 4-functionalised-2,5-diphenyloxazoles has been synthesised. Each member of the series has been assessed for the ability to scintillate in the presence of ionising radiation. The scintillation counting efficiency of each member of the series has been determined relative to 2,5-diphenyloxazole, a widely used scintillant molecule. (C) 1997 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10435-x

文献信息

• Water soluble floors
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04645618A1

  公开（公告）日：1987-02-24

  Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F].sub.x [B].sub.y [S].sub.z F is a moiety which acts as a fluor, e.g., a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-napththylmethyl, 2-napththyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e.g., dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e.g., methylene group. The variables x, y and z are integers which can generally vary from 1 to 10. A number of such compounds are disclosed, as well as methods of using such compounds, as well as compositions and products for fluorographic analysis in connection with chromotography, electrophoresis etc.

  可溶于水的氟化物在增强放射自显影中获得的图像方面是有用的，其一般公式为：[F] .sub.x [B] .sub.y [S] .sub.z，其中F是作为氟化物的一个基团，例如，化合物的脱氢衍生物是氟化物的优选例子，包括4-（2,5-二苯氧唑基） ，1-萘甲基，2-萘基和4- [5-（2-苯氧唑基）] 苯基。S是表面活性剂基团，使分子亲水性，例如，表面活性剂的脱氢衍生物；优选的例子包括聚乙二醇衍生物，磺酸或其盐，芳基磺酸盐，胺和季铵化合物。B是化学结合氟化物基团F和表面活性剂S的结合基团，可以是化学键或二取代基团，例如烷基，例如亚甲基基团。变量x，y和z是整数，通常可从1到10变化。披露了许多这样的化合物，以及使用这样的化合物的方法，以及用于色谱，电泳等荧光分析的组合物和产品。
• Water soluble fluor compositions
  申请人：E. I. Du Pont de Nemours and Company Inc.

  公开号：US04522742A1

  公开（公告）日：1985-06-11

  Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: [F].sub.x [B].sub.y [S].sub.z F is a moiety which acts as a fluor, e.g., a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthylmethyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e.g., dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e.g., methylene group. The variables x, y and z are integers which can generally vary from 1 to 10. A number of such compounds are disclosed, as well as methods of using such compounds, as well as compositions and products for fluorographic analysis in connection with chromatography, electrophoresis etc.

  可溶于水的氟化物在放射自显影中有助于增强图像，其一般式为：[F].sub.x [B].sub.y [S].sub.z，其中F是作为氟化物的一个组分，例如，一个化合物的去氢衍生物是一种氟化物；首选的例子包括4-(2,5-二苯氧唑基)苯甲基，1-萘甲基，2-萘基和4-[5-(2-苯氧唑基)]苯基。S是表面活性剂组分，使分子亲水性，例如，表面活性剂的去氢衍生物；首选的例子包括聚乙二醇衍生物，磺酸或其盐，芳基磺酸盐，胺和季铵化合物。B是结合分子，化学结合氟化物F和表面活性剂S，可以是化学键或二取代基，例如烷基，例如亚甲基基。变量x、y和z是整数，通常可以从1到10变化。披露了许多这样的化合物，以及使用这样的化合物的方法，以及与色谱、电泳等相关的荧光分析的组成物和产品。
• Water soluble fluors
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0087639A2

  公开（公告）日：1983-09-07

  Water soluble fluors useful in enhancing images obtained in autoradiography have the general formula: F is a moiety which acts as a fluor, e.g., a dehydro derivative of a compound which is a fluor; preferred examples include 4-(2,5-diphenyloxazolyl), 1-naphthyl-methyl, 2-naphthyl, and 4-[5-(2-phenyloxazolyl)]phenyl. S is a surfactant moiety which makes the molecule hydrophilic, e.g., dehydro derivatives of surfactants; preferred examples include polyethylene glycol derivatives, sulfonic acids or salts thereof, aryl sulfonates, amines and quaternary ammonium compounds. B is a binding moiety which chemically binds the fluor moiety F with the surfactant S, and may be a chemical bond, or a disubstituted moiety such as an alkylene, e.g., methylene group. The variables x, y and z are integers which can generally vary from 1 to 10. A number of such compounds are disclosed, as well as methods of using such compounds, as well as compositions and products for fluorographic analysis in connection with chromatography, electrophoresis etc.

  可用于增强自动射线照相术图像的水溶性荧光剂具有以下通式： F 是起荧光剂作用的分子，如荧光剂化合物的脱氢衍生物；首选的例子包括 4-(2,5-二苯基恶唑基)、1-萘甲基、2-萘基和 4-[5-(2-苯基恶唑基)]苯基。S 是使分子亲水的表面活性剂分子，如表面活性剂的脱氢衍生物；首选的例子包括聚乙二醇衍生物、磺酸或其盐、芳基磺酸盐、胺和季铵化合物。B 是将氟分子 F 与表面活性剂 S 化学结合的结合基，可以是化学键，也可以是二取代基，如亚 烷基，如亚甲基。变量 x、y 和 z 是整数，一般可在 1 到 10 之间变化。本发明公开了许多此类化合物、使用此类化合物的方法以及与色谱法、电泳法等有关的荧光分析组合物和产品。
• US4522742A
  申请人：——

  公开号：US4522742A

  公开（公告）日：1985-06-11
• US4645618A
  申请人：——

  公开号：US4645618A

  公开（公告）日：1987-02-24