Boc-Gly-Lys(Z)-OBzl | 37941-56-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Gly-Lys(Z)-OBzl
• 英文别名: (S)-6-benzyloxycarbonylamino-2-(2-tert-butoxycarbonylamino-acetylamino)-hexanoic acid benzyl ester；benzyl (2S)-2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]-6-(phenylmethoxycarbonylamino)hexanoate
• CAS: 37941-56-3
• 化学式: C₂₈H₃₇N₃O₇
• 分子量: 527.618
• InChiKey: WFDXYGGWXJNVOU-QHCPKHFHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  132
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Boc-Gly-Lys(Z)-OBzl 在 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 、 三氟乙酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 Boc-Asp(OBzl)-Gly-Lys(Z)-OBzl
  参考文献：
  名称：

  与免疫球蛋白E（IgE）相关的肽的合成及其药理活性的检查。

  摘要：

  五种寡肽H-Asp-Ser-Asp-OH（1），H-Asp-Gly-Lys-OH（2），H-Ser-Asp-Gly-Lys-OH（3），H-Asp-Ser通过常规溶液法合成-Asp-Gly-Lys-OH（4）和与免疫球蛋白E（IgE）有关的H-Ala-Asp-Ser-Asp-Gly-Lys-OH（5），目的是获得一种新型的抗过敏药。通过测量对IgE的抑制作用和兔主动脉平滑肌收缩的舒张来检查它们的药理活性。H-Ala-Asp-Ser-Asp-Gly-Lys-OH（5）显示出对IgE抗体产生的强力抑制作用（69.6％），对兔子主动脉的收缩具有松弛作用。

  DOI：

  10.1248/cpb.38.2463
• 作为产物：
  描述：

  BOC-甘氨酸 、 N6-[(苯基甲氧基)羰基]-L-赖氨酸苄酯 在 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 、 N-甲基吗啉 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以88%的产率得到Boc-Gly-Lys(Z)-OBzl
  参考文献：
  名称：

  The synthesis and immunosuppressive activities of steroid–urotoxin linkers

  摘要：

  The urotoxins (Glu-Asp-Gly-OH, His-Gly-Glu-OH, His-Gly-Lys-OH, and His-Gly-Lys-NHNH2) were introduced into the convenient sites of hydrocortisone and prednisolone via the amidation or condensation reactions to form the corresponding linkers 7a-d, 8a-d, 9a,b, and 10a,b in acceptable yields. The bioassays such as prolongation of heterotopic transplanted cardiac tissue survival in vivo, inhibitory effects on phagocytosis of mouse peritoneal macrophages and concanavalin (ConA) or lipopolysaccharide (LPS) induced proliferation of mouse spleen lymphocytes in vitro show that at the comparable concentrations the immuno suppressive activities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b were higher than that of hydrocortisone, prednisolone, and the urotoxins alone, as well as significantly higher than that of the mixture of hydrocortisone and urotoxins or prednisolone and urotoxins. The so-called 'permissive action' may be responsible for the enhancement of the mentioned bioactivities of the steroid-urotoxin linkers 7a-d, 8a-d, 9a,b, and 10a,b. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.06.012

文献信息

• Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic acid and derivatives thereof, process for their production and use for the production of pharmaceutical agents
  申请人：——

  公开号：US20040208828A1

  公开（公告）日：2004-10-21

  Enantiomer-pure compounds of general formulas VIIa and VIIb 1 in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.

  一种通式为VIIa和VIIb的对映纯化合物，其中A代表一个基团—COO—，Z和R具有不同的含义，以及其使用方法被描述。
• Amino acids and peptides. XXVI. Synthesis of Agaricus bisporus metallothionein and related peptides and examination of their heavy metal-binding properties.
  作者：Yasuhiro NISHIYAMA、Sigeru NAKAYAMA、Yoshio OKADA、Kyong-Son MIN、Satomi ONOSAKA、Keiichi TANAKA

  DOI：10.1248/cpb.38.2112

  日期：——

  pentacosapeptide corresponding to the entire amino acid sequence of Agaricus bisporus metallothionein (MT) and related cysteine-containing peptides were prepared by the conventional solution method and their heavy metal-binding properties were examined. The Cu2(+)- or Cu(+)-binding activities of various peptides were not greatly dependent on the peptide structure, so far as examined, although the pentacosapeptide

  通过常规溶液法制备了与双孢蘑菇金属硫蛋白（MT）的整个氨基酸序列相对应的五肽和相关的含半胱氨酸的肽，并检查了它们的重金属结合特性。到目前为止，各种肽的Cu2 +或Cu（+）结合活性并不很大地依赖于肽的结构，尽管五糖肽A. bisporus MT的结合活性比其他肽稍高。相反，这些肽的Cd2（+）结合活性是相当结构依赖性的。
• Peptides as antiallergic agents
  申请人：Hitachi Chemical Co., Ltd.

  公开号：US05223487A1

  公开（公告）日：1993-06-29

  The following oligopeptides containing -Asp-Gly- or -Asp-Ser- are synthesized: H-Asp-Gly-Lys-OH H-Ser-Asp-Gly-Lys-OH H-Asp-Ser-Asp-Gly-Lys-OH H-Ala-Asp-Ser-Asp-Gly-Lys-OH The oligopeptides have antiallergic, vasodilating and immunoregulating activities and are very useful for treating allergic symptoms.

  以下寡肽含有-Asp-Gly-或-Asp-Ser-：H-Asp-Gly-Lys-OH，H-Ser-Asp-Gly-Lys-OH，H-Asp-Ser-Asp-Gly-Lys-OH，H-Ala-Asp-Ser-Asp-Gly-Lys-OH。这些寡肽具有抗过敏、扩张血管和免疫调节活性，对于治疗过敏症状非常有用。
• Peptides and intermediates therefor useful as antiallergic agents,
  申请人：Hitachi Chemical Co., Ltd.

  公开号：US05118669A1

  公开（公告）日：1992-06-02

  The following oligopeptides containing -Asp-Gly- or -Asp-Ser- are synthesized: H-Asp-Gly-Lys-OH H-Ser-Asp-Gly-Lys-OH H-Asp-Ser-Asp-Gly-Lys-OH H-Ala-Asp-Ser-Asp-Gly-Lys-OH The oligopeptides have antiallergic, vasodilating and immunoregulating activities and are very useful for treating allergic symptons.

  以下寡肽包含-Asp-Gly-或-Asp-Ser-：H-Asp-Gly-Lys-OH、H-Ser-Asp-Gly-Lys-OH、H-Asp-Ser-Asp-Gly-Lys-OH、H-Ala-Asp-Ser-Asp-Gly-Lys-OH。这些寡肽具有抗过敏、扩张血管和免疫调节活性，非常适用于治疗过敏症状。
• Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents
  申请人：LEHMANN Lutz

  公开号：US20120064002A1

  公开（公告）日：2012-03-15

  Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.

  本文描述了通式VIIa和VIIb的对映体纯化合物，其中A代表一个羧基（—COO—），Z和R具有不同的含义，以及它们的使用。