phosphorochloridous acid di-tert-butyl ester | 78543-77-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phosphorochloridous acid di-tert-butyl ester
• 英文别名: Di-tert-butyl-chlorphosphit；DI-Tert-butylphosphorochloridite；chloro-bis[(2-methylpropan-2-yl)oxy]phosphane
• CAS: 78543-77-8
• 化学式: C₈H₁₈ClO₂P
• 分子量: 212.656
• InChiKey: NNLQAVXYYOHHBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  phosphorochloridous acid di-tert-butyl ester 在 四氮唑 作用下， 以 乙醚 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  亚磷酰胺作为O-磷酸化剂及其反应性的研究

  摘要：

  摘要 O-磷酸化肽和氨基酸在生命系统中很重要。本文采用两种方法合成了二烷基-N,N-二烷基亚磷酰胺(DDPA) 3 。在四唑的存在下，DDPA与相应氨基酸的羟基反应，然后氧化，以良好的产率得到O-磷酰基氨基酸甲酯。还介绍了 DDPA 反应性的系统研究。

  DOI：

  10.1080/10426500008045253
• 作为产物：
  描述：

  三-叔-丁基亚磷酸 在 三氯化磷 作用下， 生成 phosphorochloridous acid di-tert-butyl ester
  参考文献：
  名称：

  亚磷酰胺作为O-磷酸化剂及其反应性的研究

  摘要：

  摘要 O-磷酸化肽和氨基酸在生命系统中很重要。本文采用两种方法合成了二烷基-N,N-二烷基亚磷酰胺(DDPA) 3 。在四唑的存在下，DDPA与相应氨基酸的羟基反应，然后氧化，以良好的产率得到O-磷酰基氨基酸甲酯。还介绍了 DDPA 反应性的系统研究。

  DOI：

  10.1080/10426500008045253

文献信息

• Hydroxamic Acid Derivatives Useful As Antibacterial Agents
  申请人：Pfizer Inc.

  公开号：US20140206651A1

  公开（公告）日：2014-07-24

  The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II): and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B, L 1 -L 4 , A, B, R 1 -R 4 , and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.

  本发明涉及式(I)的化合物：或其药学上可接受的盐，其中：G是式(II)的基团：以及其药学上可接受的盐、前药、水合物或溶剂化物，其中A、B、L1-L4、A、B、R1-R4和m的定义如本文所述。本发明还涉及包含式(I)化合物的制药组合物及其在治疗细菌感染中的应用。
• A trithiophosphoric acid ester as a soil pesticide
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0138586A1

  公开（公告）日：1985-04-24

  Trithiophosphoric acid esters of formula: wherein R1 is a methyl or ethyl group, useful as soil pesticides, are prepared from the corresponding phosphoric acids or the corresponding phosphites.

  式中 R1 为甲基或乙基的三硫代磷酸酯可用作土壤杀虫剂： 其中 R1 是甲基或乙基，可用作土壤杀虫剂，由相应的磷酸或相应的亚磷酸酯制备而成。
• Nonoxidative chlorination of dialkyl phosphonates to dialkyl phosphorochloridites. A new approach to oligonucleotide synthesis
  作者：Takeshi Wada、Ryohei Kato、Tsujiaki Hata

  DOI：10.1021/jo00003a056

  日期：1991.2

  Several dialkyl phosphonates and alkyl nucleoside 3'-phosphonates were transformed into the corresponding highly reactive phosphorochloridites without oxidation of phosphorus by use of tris(2,4,6-tribromophenoxy)-dichlorophosphorane (BDCP) as a chlorinating reagent. The reaction was applied to internucleotidic bond formation. 2-Cyanoethyl and methyl nucleoside 3'-phosphonates were prepared in high yields and were stable enough to be used as starting materials in oligonucleotide synthesis. Examination of dodecathymidylate synthesis on a polymer support, using 2-cyanoethyl or methyl nucleoside 3'-phosphonate as building blocks, showed that the 2-cyanoethyl nucleoside 3'-phosphonate was more effective.
• Dopant Group-Substituted Semiconductor Precursor Compounds, Compositions Containing the Same, and Methods of Making Such Compounds and Compositions
  申请人：GUO Wenzhuo

  公开号：US20110178321A1

  公开（公告）日：2011-07-21

  Dopant-group substituted (cyclo)silane compounds, liquid-phase compositions containing such compounds, and methods for making the same. Such compounds (and/or ink compositions containing the same) are useful for printing or spin coating a doped silane film onto a substrate that can easily be converted into a doped amorphous or polycrystalline silicon film suitable for electronic devices. Thus, the present invention advantageously provides commercial qualities and quantities of doped semiconductor films from a doped “liquid silicon” composition.
• US4607027A
  申请人：——

  公开号：US4607027A

  公开（公告）日：1986-08-19