1-(but-3-yn-1-yl)-1,2,3,4-tetrahydroquinoline | 1128054-74-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(but-3-yn-1-yl)-1,2,3,4-tetrahydroquinoline
• 英文别名: 1-but-3-ynyl-3,4-dihydro-2H-quinoline
• CAS: 1128054-74-9
• 化学式: C₁₃H₁₅N
• 分子量: 185.269
• InChiKey: XCRBFYGHKYVQTF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(but-3-yn-1-yl)-1,2,3,4-tetrahydroquinoline 在 碳酸氢钠 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Gold or No Gold: One-Pot Synthesis of Tetrahydrobenz[b]azepin-4-ones from Tertiary N-(But-3-ynyl)anilines

  摘要：

  Depending on the tertiary aniline substrates, an efficient, one-pot synthesis of tetrahydrobenz[b]azepin-4-ones needs either gold catalysts or no catalyst at all. In the reaction, the aniline nitrogen plays a unique role in relaying "O" from m-CPBA to a tethered C-C triple bond, which is inert to the oxidant under the mild reaction conditions.

  DOI：

  10.1021/ol900027h
• 作为产物：
  描述：

  1,2,3,4-四氢喹啉 、 4-碘-1-丁炔 在 potassium carbonate 作用下， 反应 4.0h， 以72%的产率得到1-(but-3-yn-1-yl)-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Gold or No Gold: One-Pot Synthesis of Tetrahydrobenz[b]azepin-4-ones from Tertiary N-(But-3-ynyl)anilines

  摘要：

  Depending on the tertiary aniline substrates, an efficient, one-pot synthesis of tetrahydrobenz[b]azepin-4-ones needs either gold catalysts or no catalyst at all. In the reaction, the aniline nitrogen plays a unique role in relaying "O" from m-CPBA to a tethered C-C triple bond, which is inert to the oxidant under the mild reaction conditions.

  DOI：

  10.1021/ol900027h

文献信息

• CARBALDEHYDE OXIMES AS BUTYRYLCHOLINESTERASE REACTIVATORS
  申请人：Etat Français représenté par la Direction Centrale Du Service de Santé des Armées

  公开号：EP3945092A1

  公开（公告）日：2022-02-02

  The present invention relates to compounds for their use in the reactivation of butyrylcholinesterase. Such compounds are useful in the treatment or prevention of the intoxication with at least one organophosphorus nerve agent. The invention also relates to pharmaceutical compositions and kits comprising said compounds, and compounds per se.

  本发明涉及化合物，用于重新激活丁酰胆碱酯酶。这些化合物在治疗或预防至少一种有机磷神经毒剂中毒方面是有用的。该发明还涉及包含所述化合物的药物组合物和试剂盒，以及化合物本身。
• A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes
  作者：Chuan-Jin Hou、Alexander W. Schuppe、James Levi Knippel、Anton Z. Ni、Stephen L. Buchwald

  DOI：10.1021/acs.orglett.1c03324

  日期：2021.11.19

  synthetic chemistry. Herein, we report a method for the stereoselective hydroalkenylation of alkynes, utilizing readily available enol triflates. We leveraged an in situ-generated and geometrically pure vinyl-Cu(I) species to form the Z,Z- or Z,E-1,3-dienes in excellent stereoselectivity and yield. This approach allowed for the synthesis of highly substituted Z-dienes, including pentasubstituted 1,3-dienes

  共轭二烯是合成化学中的通用结构单元和普遍的子结构。在此，我们报告了一种利用容易获得的烯醇三氟甲磺酸酯对炔烃进行立体选择性加氢烯基化的方法。我们利用原位生成的几何纯乙烯基-Cu(I)物种以优异的立体选择性和产率形成Z , Z - 或Z , E -1,3-二烯。这种方法可以合成高度取代的Z-二烯，包括五取代的1,3-二烯，这些物质很难通过现有方法制备。
• Gold or No Gold: One-Pot Synthesis of Tetrahydrobenz[<i>b</i>]azepin-4-ones from Tertiary <i>N</i>-(But-3-ynyl)anilines
  作者：Li Cui、Guozhu Zhang、Yu Peng、Liming Zhang

  DOI：10.1021/ol900027h

  日期：2009.3.19

  Depending on the tertiary aniline substrates, an efficient, one-pot synthesis of tetrahydrobenz[b]azepin-4-ones needs either gold catalysts or no catalyst at all. In the reaction, the aniline nitrogen plays a unique role in relaying "O" from m-CPBA to a tethered C-C triple bond, which is inert to the oxidant under the mild reaction conditions.