1-acetyl-N-(3-acetylphenyl)piperidine-4-carboxamide | 1090017-04-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-acetyl-N-(3-acetylphenyl)piperidine-4-carboxamide
• CAS: 1090017-04-1
• 化学式: C₁₆H₂₀N₂O₃
• 分子量: 288.346
• InChiKey: DNDWTUSHIPHDTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-acetyl-N-(3-acetylphenyl)piperidine-4-carboxamide 、 2-(4-氯苯氧基)苯胺 在 三异丙氧基氯化钛 、 三乙酰氧基硼氢化钠 、 碳酸氢钠 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 0.34h， 以18%的产率得到1-acetyl-N-(3-(1-(2-(4-chlorophenoxy)phenylamino)ethyl)phenyl)piperidine-4-carboxamide
  参考文献：
  名称：

  [EN] INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASE
  [FR] COMPOSÉ

  摘要：

  公开号：

  WO2009066072A3

文献信息

• Compound capable of inhibiting 17-beta hydroxysteriod dehydrogenase
  申请人：Vicker Nigel

  公开号：US08558028B2

  公开（公告）日：2013-10-15

  There is provided a compound having Formula I wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, —OC(R13)3, —OCH(R13)2, —OCH2R13, C(R13)3, —CH(R13)2, or —CH2R13 wherein R13 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO2-alkyl; and (n) —N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S(═O)2, C═O, S(═O)2NR16, C═ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C═O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups.

  提供了一种化合物，其化学式为I，其中R1、R2、R3、R4、R5、R6、R7、R8和R9中的每一个都是独立选择自(a) H，(b) R13，—OC(R13)3，—OCH(R13)2，—OCH2R13，C(R13)3，—CH(R13)2或—CH2R13，其中R13是卤素；(c) —CN；(d) 可选取代的烷基，(e) 可选取代的杂基烷基；(f) 可选取代的芳基；(g) 可选取代的杂芳基；(h) 可选取代的芳基烷基；(i) 可选取代的杂芳基烷基；(j) 羟基；(k) 烷氧基；(l) 芳氧基；(m) —SO2-烷基；和(n) —N(R14)C(O)R15，其中R14和R15独立选择为H和烃基，(d) (e) (f) (h)和(i)的可选取代基团选择自C1-6烷基，卤素，氰基，硝基，卤代烷基，羟基，C1-6烷氧基，羧基，羧基烷基，羧酰胺，巯基，氨基，烷基氨基，二烷基氨基，磺酰基，磺酰胺基，芳基和杂芳基；其中n和p独立选择自0和1；X是可选的基团，选择自O、S、S=0、S(═O)2、C═O、S(═O)2NR16、C═ONR17、NR18，其中R16、R17和R18独立选择为H和烃基，R10选择自H和烃基，R11选择自CR19R20和C═O，其中R19和R20独立选择为H和烃基，R12选择自可选取代的五元或六元含有一个或多个杂原子(N、S和O)的碳环，可选地与另一个环融合，并且其中一个或多个取代基团选择自烃基团。
• COMPOUND CAPABLE OF INHIBITING 17-BETA HYDROXYSTERIOD DEHYDROGENASE
  申请人：Vicker Nigel

  公开号：US20100286204A1

  公开（公告）日：2010-11-11

  There is provided a compound having Formula I wherein each of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are independently selected from (a) H, (b) R 13 , —OC(R 13 ) 3 , —OCH(R 13 ) 2 , —OCH 2 R 13 , C(R 13 ) 3 , —CH(R 13 ) 2 , or —CH 2 R 13 wherein R 13 is a halogen; (c) —CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (l) aryloxy; (m) —SO 2 -alkyl; and (n) —N(R 14 )C(O)R 15 , wherein R 14 and R 15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (f) (h) and (i) are selected from the group consisting of: C 1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C 1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=0, S(═O) 2 , C═O, S(═O) 2 NR 16 , C═ONR 17 , NR 18 , in which R 16 , R 17 , and R 18 are independently selected from H and hydrocarbyl, R 10 is selected from H and hydrocarbyl, R 11 is selected from CR 19 R 20 and C═O, in which R 19 and R 20 are independently selected from H and hydrocarbyl, R 12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups.

  提供了一种化合物，其具有以下化学式I，其中R1、R2、R3、R4、R5、R6、R7、R8和R9分别独立地选择自(a) H、(b) R13、-OC(R13)3、-OCH(R13)2、-OCH2R13、C(R13)3、-CH(R13)2或-CH2R13，其中R13是卤素；(c) -CN；(d) 可选取代的烷基；(e) 可选取代的杂环烷基；(f) 可选取代的芳基；(g) 可选取代的杂芳基；(h) 可选取代的芳基烷基；(i) 可选取代的杂芳基烷基；(j) 羟基；(k) 烷氧基；(l) 芳氧基；(m) -SO2-烷基；和(n) -N(R14)C(O)R15，其中R14和R15独立地选择自H和烃基，(d)、(e)、(f)、(h)和(i)的可选取代基团选择自以下群中的一种：C1-6烷基、卤素、氰基、硝基、卤代烷基、羟基、C1-6烷氧基、羧基、羧基烷基、羧酰胺基、巯基、氨基、烷基氨基、二烷基氨基、磺酰基、磺酰胺基、芳基和杂芳基；其中n和p独立地选择自0和1；X是可选的基团，选择自O、S、S=0、S(═O)2、C═O、S(═O)2NR16、C═ONR17、NR18，其中R16、R17和R18独立地选择自H和烃基，R10选择自H和烃基，R11选择自CR19R20和C═O，其中R19和R20独立地选择自H和烃基，R12选择自可选取代的含有一个或多个杂原子(N、S和O)的取代的五元或六元碳环，且可选择进一步融合环，其中一个或多个取代基团选择自烃基团。
• INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASE
  申请人：Sterix Limited

  公开号：EP2220026A2

  公开（公告）日：2010-08-25
• US8558028B2
  申请人：——

  公开号：US8558028B2

  公开（公告）日：2013-10-15
• [EN] COMPOUND<br/>[FR] COMPOSÉ
  申请人：STERIX LTD

  公开号：WO2009066072A2

  公开（公告）日：2009-05-28

  There is provided a compound having Formula (I), wherein each of R1, R2, R3, R4, R5, R6, R7, R8 and R9 are independently selected from (a) H, (b) R13, -OC(R13)3, -OCH(R13)2, -OCH2R13, -C(R13)3, -CH(R13)2, or -CH2R13 wherein R13 is a halogen; (c) -CN; (d) optionally substituted alkyl, (e) optionally substituted heteroalkyl; (f) optionally substituted aryl; (g) optionally substituted heteroaryl; (h) optionally substituted arylalkyl; (i) optionally substituted heteroarylalkyl; (j) hydroxy; (k) alkoxy; (I) aryloxy; (m) -SO2-alkyl; and (n) -N(R14)C(O)R15, wherein R14 and R15 are independently selected from H and hydrocarbyl, wherein the optional substituents of (d) (e) (T) (h) and (i) are selected from the group consisting of: C1-6 alkyl, halo, cyano, nitro, haloalkyl, hydroxy, C1-6 alkoxy, carboxy, carboxyalkyl, carboxamide, mercapto, amino, alkylamino, dialkylamino, sulfonyl, sulfonamido, aryl and heteroaryl; wherein n and p are independently selected from 0 and 1; X is an optional group selected from O, S, S=O, S(=O)2, C=O, S(=O)2NR16, C=ONR17, NR18, in which R16, R17, and R18 are independently selected from H and hydrocarbyl, R10 is selected from H and hydrocarbyl, R11 is selected from CR19R20 and C=O, in which R19 and R20 are independently selected from H and hydrocarbyl, R12 is selected from a substituted five or six membered carbon rings optionally containing one or more hetero atoms selected from N, S, and O and optionally having fused thereto a further ring, and wherein the one or more substituents are selected from hydrocarbyl groups.