3-oxo-3-(3-trifluoromethyl-phenyl)-propionic acid | 335256-27-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-oxo-3-(3-trifluoromethyl-phenyl)-propionic acid
• 英文别名: Benzenepropanoic acid, beta-oxo-3-(trifluoromethyl)-；3-oxo-3-[3-(trifluoromethyl)phenyl]propanoic acid
• CAS: 335256-27-4
• 化学式: C₁₀H₇F₃O₃
• 分子量: 232.159
• InChiKey: ODTVKMNSRRLGQP-UHFFFAOYSA-N

物化性质

• 沸点：
  325.8±42.0 °C(Predicted)
• 密度：
  1.401±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  bis(trimethylsilyl)malonate 、 3-(三氟甲基)苯甲酰氯 在 三乙胺 、 lithium bromide 作用下， 以 乙酸异丙烯酯 、 乙腈 为溶剂， 生成 3-oxo-3-(3-trifluoromethyl-phenyl)-propionic acid 、 2,2-Dimethyl-6-(3-trifluoromethyl-phenyl)-[1,3]dioxin-4-one
  参考文献：
  名称：

  Glutamate receptor antagonists

  摘要：

  本发明是一个化合物，其化学式为 其中 X是一个乙炔基团，R1、R2和R3如规范中所定义。

  公开号：

  US06509328B1

文献信息

• SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF 11BETA-HSD-1
  申请人：Bartberger D. Michael

  公开号：US20080021022A1

  公开（公告）日：2008-01-24

  Compounds of formula I and IV are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorder: wherein the variables A-B, R 1 , R 2 , m, and Q are described herein.

  化合物的公式I和IV已经描述，并具有治疗效用，特别是在治疗糖尿病、肥胖和相关疾病和紊乱方面： 其中变量A-B、R1、R2、m和Q在此处描述。
• [EN] KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION<br/>[FR] INHIBITEURS DE KV1.3 ET LEUR APPLICATION MÉDICALE
  申请人：4SC DISCOVERY GMBH

  公开号：WO2016146583A1

  公开（公告）日：2016-09-22

  The present invention relates to a compound of the general formula (II) or a salt or solvate thereof, as well as medical uses involving them, wherein A1 is selected from the group consisting of N and C-R8; A2 is selected from the group consisting of N and C-R3, A3 is selected from the group consisting of N and C-R9; A4 and A5 and A6 are independently selected from the group consisting of N and C-R1; R1 is selected from the group consisting of hydrogen, (C1-C3)alkyl, halogen, (C1-C3)alkoxy, and (C1-C3)haloalkyl; R2 is selected from the group consisting of hydrogen, halogen, and (C1-C3)alkyl; R3 is selected from the group consisting of hydrogen, (C1-C3)alkyl, NR4R5, (C1-C3)alkyl- NR4R5, and cyano, wherein R4 and R5 are independently selected from the group consisting of hydrogen, (C3-C5)cycloalkyl, (C3-C5)heterocycloalkyl and (C1-C3)alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally comprising in addition to the aforementioned nitrogen atom a further heteroatom group selected from the group consisting of O and NR6, wherein R6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl; Y is selected from the group consisting of O and S; R8 is selected from the group consisting of (C1-C4)alkyl, (C3-C5)cycloalkyl and (C3-C5)heterocycloalkyl; and R9 is selected from the group consisting of hydrogen, (C1-C3)alkyl and (C1-C3)alkoxy; wherein certain particular compounds are excluded py proviso, and methods for producing such compounds.

  本发明涉及一般式（II）的化合物或其盐或溶剂络合物，以及涉及它们的医药用途，其中A1从N和C-R8组成的组中选择；A2从N和C-R3组成的组中选择，A3从N和C-R9组成的组中选择；A4、A5和A6独立地从N和C-R1组成的组中选择；R1从氢、（C1-C3）烷基、卤素、（C1-C3）烷氧基和（C1-C3）卤代烷基组成的组中选择；R2从氢、卤素和（C1-C3）烷基组成的组中选择；R3从氢、（C1-C3）烷基、NR4R5、（C1-C3）烷基-NR4R5和氰基组成的组中选择，其中R4和R5独立地从氢、（C3-C5）环烷基、（C3-C5）杂环烷基和（C1-C3）烷基组成的组中选择，或者R4和R5与它们连接的氮原子一起形成一个5至7元杂环，该环可选地包括除上述氮原子外进一步选择的O和NR6等杂原子基团，其中R6从氢、甲基、乙酰基和甲酰基组成的组中选择；Y从O和S组成的组中选择；R8从（C1-C4）烷基、（C3-C5）环烷基和（C3-C5）杂环烷基组成的组中选择；R9从氢、（C1-C3）烷基和（C1-C3）烷氧基组成的组中选择；其中特定的某些化合物受限制，以及生产这种化合物的方法。
• [EN] KV1.3 INHIBITORS AND THEIR MEDICAL APPLICATION<br/>[FR] INHIBITEURS KV1.3 ET APPLICATION MÉDICALE CORRESPONDANTE
  申请人：4SC DISCOVERY GMBH

  公开号：WO2016146575A1

  公开（公告）日：2016-09-22

  The present invention relates to a compound of the general formula (III) or a salt, solvate or prodrug thereof, as well as medical uses involving them, wherein (III) A1 is selected from the group consisting of N and C-R8; A2 is selected from the group consisting of N and C-R3; A3 is selected from the group consisting of N and C-R9; A4 and A5 and A6 are independently selected from the group consisting of N and C-R1; R1 is selected from the group consisting of hydrogen, (C1-C3)alkyl, halogen, (C1-C3)alkoxy and (C1-C3)haloalkyl; R2 is selected from the group consisting of hydrogen, halogen and (C1-C3)alkyl; R3 is selected from the group consisting of hydrogen, (C1-C3)alkyl, NR4R5, (C1-C3)alkyl- NR4R5 and cyano; wherein R4 and R5 are independently selected from the group consisting of hydrogen, (C3- C5)cycloalkyl, (C3-C5)heterocycloalkyl, (C1-C3)alkyl, or R4 and R5 together with the nitrogen atom to which they are attached form a 5- to 7-membered heterocyclic ring optionally comprising in addition to the aforementioned nitrogen atom a further heteroatom group selected from the group consisting of O and NR6, wherein R6 is selected from the group consisting of hydrogen, methyl, acetyl and formyl; Y is selected from the group consisting of O and S; R7 is selected from the group consisting of hydrogen, and (C1-C3)alkyl; R8 is selected from the group consisting of (C1-C4)alkyl, (C3-C5)cycloalkyl, and (C3- C5)heterocycloalkyl; R9 is selected from the group consisting of hydrogen, (C1-C3)alkyl, (C1-C3)alkoxy, and methods for producing such compounds.

  本发明涉及一般式（III）的化合物或其盐、溶剂合物或前药，以及涉及它们的医药用途，其中（III）A1选自由N和C-R8组成的群；A2选自由N和C-R3组成的群；A3选自由N和C-R9组成的群；A4、A5和A6独立地选自由N和C-R1组成的群；R1选自由氢、（C1-C3）烷基、卤素、（C1-C3）烷氧基和（C1-C3）卤代烷基组成的群；R2选自由氢、卤素和（C1-C3）烷基组成的群；R3选自由氢、（C1-C3）烷基、NR4R5、（C1-C3）烷基-NR4R5和氰基；其中R4和R5独立地选自由氢、（C3-C5）环烷基、（C3-C5）杂环烷基、（C1-C3）烷基，或R4和R5与它们连接的氮原子一起形成一个5至7成员的杂环，该杂环可选地包括除前述氮原子外，另外选自O和NR6的杂原子团，其中R6选自由氢、甲基、乙酰基和甲酰基；Y选自由O和S组成的群；R7选自由氢和（C1-C3）烷基；R8选自由（C1-C4）烷基、（C3-C5）环烷基和（C3-C5）杂环烷基组成的群；R9选自由氢、（C1-C3）烷基、（C1-C3）烷氧基，以及生产这种化合物的方法。
• AMIDE DERIVATIVES AND DRUG COMPOSITIONS
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1156045A1

  公开（公告）日：2001-11-21

  The present invention is composed of an amide derivative represented by the following formula [1] or pharmaceutically acceptable salt thereof:    wherein R1 and R2 may be the same or different and each is hydrogen, alkyl which may be substituted, acyl, aryl which may be substituted, or an aromatic heterocyclic group which may be substituted; R3, R4, R5, and R6 may be the same or different and each is hydrogen, halogen, hydroxy, amino which may be substituted, alkyl which may be substituted, alkoxy, or nitro and the like; and R7 represents cyclic amino which may be substituted or azabicycloalkylamino which may be substituted, and a pharmaceutical composition which comprises it as an active ingredient. The compound of the invention is useful as an inhibitor of TGF-β production or an antagonist of TGF-β.

  本发明由下式[1]代表的酰胺衍生物或其药学上可接受的盐组成： 其中R1和R2可以相同或不同，各自为氢、可被取代的烷基、酰基、可被取代的芳基或可被取代的芳杂环基团；R3、R4、R5和R6可以相同或不同，各自为氢、卤素、羟基、可被取代的氨基、可被取代的烷基、烷氧基或硝基等；R7代表可被取代的环氨基或可被取代的氮杂环烷基氨基，以及将其作为活性成分的药物组合物。 本发明的化合物可用作 TGF-β 生成的抑制剂或 TGF-β 的拮抗剂。
• MEDICINAL COMPOSITION
  申请人：Nippon Shinyaku Co., Ltd.

  公开号：EP1243268A1

  公开（公告）日：2002-09-25

  The present invention is composed of a pharmaceutical composition for the therapy of nephritis which comprises an amide derivative represented by the following formula [1] or pharmaceutically acceptable salt thereof, as an active ingredient:    wherein R1 and R2 may be the same or different and each is hydrogen, alkyl which may be substituted, acyl, aryl which may be substituted, or an aromatic heterocyclic group which may be substituted; R3, R4, R5 and R6 may be the same or different and each is hydrogen, halogen, hydroxy, amino which may be substituted, alkyl which may be substituted, alkoxy or nitro and the like; and R7 represents cyclic amino which may be substituted or azabicycloalkylamino which may be substituted. The pharmaceutical composition of the invention is useful for the therapy of nephritis.

  本发明由一种治疗肾炎的药物组合物组成，该药物组合物包括下式[1]代表的酰胺衍生物或其药学上可接受的盐作为活性成分： 其中 R1 和 R2 可以相同或不同，各自为氢、可被取代的烷基、酰基、可被取代的芳基或可被取代的芳香杂环基团；R3、R4、R5 和 R6 可以相同或不同，各自为氢、卤素、羟基、可被取代的氨基、可被取代的烷基、烷氧基或硝基等；R7 代表可被取代的环氨基或可被取代的氮杂环烷基氨基。 本发明的药物组合物可用于治疗肾炎。