1-(2-(1H-indol-5-yl)phenyl)ethanone | 1087349-08-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-(1H-indol-5-yl)phenyl)ethanone
• 英文别名: 1-[2-(1H-indol-5-yl)phenyl]ethanone
• CAS: 1087349-08-3
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: WYEMXWZHKVWNCD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-碘吲哚 、 2'-碘苯乙酮 在 indium 、 十三烷 、 lithium chloride 、 2-双环己基膦-2',6'-二甲氧基联苯 、 palladium diacetate 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 29.0h， 以71%的产率得到1-(2-(1H-indol-5-yl)phenyl)ethanone
  参考文献：
  名称：

  通过在LiCl存在下直接插入铟来制备芳基和杂芳基铟（III）试剂。

  摘要：

  DOI：

  10.1002/anie.200802292

文献信息

• Novel modulators of potassium channels
  申请人：4SC AG

  公开号：US20030203959A1

  公开（公告）日：2003-10-30

  The invention relates to the use of a compound of the Formula (I) 1 or a salt, a physiologically functional derivative, or a prodrug thereof as a medicament, wherein R is a monocyclic or polycyclic substituted or unsubstituted aromatic ring system which may contain one or more groups X and which contains at least one aromatic ring; X is selected from the group consisting of S, O, N, NR′, SO or SO 2 ; R is optionally substituted by one to four substituents which are independently selected from the group consisting of halogen, CF 3 , OCF 3 , alkyl, cycloalkyl, haloalkyl, haloalkyloxy, hydroxyalkyl, hydroxyalkylamine, amine, aminoalkyl, alkylamine, CR′O, CO 2 R′, alkoxy, alkylthio, alkylaryl, alkylsulfonyl, H, hydroxy, aryl, heteroaryl, —NR′OR′, CN, alkylsulfinyl, arylsulfonyl, heteroarylsulfonyl, SO 3 R′, NO 2 , —CO—NR′R 1 , arylalkyl-O—, —O-aryl, —O-heteroaryl, arylalkyl-S—, —S-aryl, —S-heteroaryl, —NR 1 —SO 2 R′, —SO 2 —NR I -alkyl, —SO 2 —NR 1 -aryl, and —SO 2 —N 1 -heteroaryl.

  本发明涉及式（I）化合物的用途 1 或其盐、生理功能衍生物或其原药作为药物，其中 R 是单环或多环取代或未取代的芳香环系统，可包含一个或多个基团 X，且至少包含一个芳香环； X 选自 S、O、N、NR′、SO 或 SO 2 ; R 可任选被一至四个取代基取代，这些取代基独立地选自由卤素、CF 3 、OCF 3 烷基、环烷基、卤代烷基、卤代烷氧基、羟基烷基、羟基烷基胺、胺、氨基烷基、烷基胺、CR′O、CO 2 R′、烷氧基、烷硫基、烷芳基、烷基磺酰基、H、羟基、芳基、杂芳基、-NR′OR′、CN、烷基亚磺酰基、芳基磺酰基、杂芳基磺酰基、SO 3 R′、NO 2 、-CO-NR′R 1 ，芳烷基-O-，-O-芳基，-O-杂芳基，芳烷基-S-，-S-芳基，-S-杂芳基，-NR 1 -SO 2 R′、-SO 2 -NR I -烷基、-SO 2 -NR 1 -芳基和 -SO 2 -N 1 -杂芳基。
• [EN] INDOLE DERIVATIVES AS MODULATORS OF POTASSIUM CHANNELS<br/>[FR] MODULATEURS DES CANAUX POTASSIQUES A BASE DE DERIVES INDOLE
  申请人：4SC AG

  公开号：WO2003074047A1

  公开（公告）日：2003-09-12

  The invention relates to the use of a compound of the Formula (1) or a salt, a physiologically functional derivative, or a prodrug thereof as a medicament, wherein R is a monocyclic or polycyclic substituted or unsubstituted aromatic ring system which may contain one or more groups X and which contains at least one aromatic ring; X is selected from the group consisting of S, O, N, NR', SO or SO2; R is optionally substituted by one to four substituents which are independently selected from the group consisting of halogen, CF3, OCF3, alkyl, cycloalkyl, haloalkyl, haloalkyloxy, hydroxyalkyl, hydroxyalkylamine, amine, aminoalkyl, alkylamine, CR' O, CO2R', alkoxy, alkylthio, alkylaryl, alkylsulfonyl, H, hydroxy, aryl, heteroaryl, -NR'OR', CN, alkylsulfinyl, arylsulfonyl, heteroarylsulfonyl, SO3R', NO2, -CO-NR' RI, arylalkyl-O-, -O-aryl, -O-heteroaryl,arylalkyl-S-, -S-aryl, -S-heteroaryl, -NR1-SO2R', -SO2-NR1-alkyl, -SO2-NR1-aryl, and -SO2-NR1-heteroaryl.