2-(chloromethylene)butanal | 36610-88-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(chloromethylene)butanal
• 英文别名: 3-chloro-2-ethyl-propenal；2-ethyl-3-chloro-acrylaldehyde；2-Aethyl-3-chlor-acrylaldehyd；2-(Chloromethylidene)butanal；2-(chloromethylidene)butanal
• CAS: 36610-88-5
• 化学式: C₅H₇ClO
• 分子量: 118.563
• InChiKey: OPBJDFZEHRBBEE-UHFFFAOYSA-N

物化性质

• 沸点：
  50-55 °C(Press: 22 Torr)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  7
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(chloromethylene)butanal 在 chromium(VI) oxide 、 4-二甲氨基吡啶 、 lithium aluminium tetrahydride 、 硫酸 、 水 、 sodium hydride 、 N,N'-二环己基碳二亚胺 、 锌 作用下， 以 六甲基磷酰三胺 、 乙醚 、 二氯甲烷 、 丙酮 、 苯 为溶剂， 反应 19.0h， 生成 4-(chloromethylene)-3-methoxyhex-2-enyl benzoate
  参考文献：
  名称：

  长春花生物碱和相关化合物 103 的合成。意外反应的识别及其在构建 Aspidospermane 骨架中的应用。15b-羟基长春花碱的简单合成

  摘要：

  色胺衍生物 (2b) 和由 2-(氯亚甲基) 丁醛 (4) 形成的乙酸酯 (11) 反应生成烯胺酮 (14)。14 的脱水和随后的分子内 [4+2] 环加成导致 15-oxovincadifformine (15)。后一种分子的区域选择性和立体选择性还原提供了 15β-羟基长春二甲双胍 (1)。

  DOI：

  10.3987/com-05-10603
• 作为产物：
  描述：

  2-二乙氧基甲基-1,1-二乙氧基丁烷 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 2-(chloromethylene)butanal
  参考文献：
  名称：

  Klimko,V.T. et al., Journal of general chemistry of the USSR, 1964, vol. 34, # 1, p. 108 - 112

  摘要：

  DOI：

文献信息

• Arnold; Zemlicka, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 2385,2390
  作者：Arnold、Zemlicka

  DOI：——

  日期：——
• Determinants of Body Composition in Postmenopausal Women
  作者：J. M. Hagberg、J. M. Zmuda、S. D. McCole、K. S. Rodgers、K. R. Wilund、G. E. Moore

  DOI：10.1093/gerona/55.10.m607

  日期：2000.10.1

  Background. Little is known about the effects of different levels of long-term physical activity on total body and regional fat and whether hormone replacement therapy interacts with physical activity level to affect body composition in postmenopausal women.Methods. We determined the associations between different levels of habitual physical activity, hormone replacement therapy (HRT), and total and regional body composition in postmenopausal women. Twenty sedentary, 20 active nonathletic, and 23 endurance-trained women (approximately half on HRT) had total and regional body composition assessed by dual-energy x-ray absorptiometry. The athletes and active nonathletic women had been active for the same number of years and the same number of hours per week.Results, The athletes and sedentary women weighed the same, but the active nonathletic groups on and not on HRT weighed 3-12 kg more (p < .05). Athletes had less trunk, arm, leg, and total body fat than sedentary and active nonathletic women (p < .05). Women on HRT tended to have lower total body (p = .07), but not regional, fat values. Linear regression analyses indicated that (V) over dot O-2 max in ml/kg/min was the major independent determinant of total and regional; body fat accounting for 52% to 70% of their variances. Athletes had greater caloric and carbohydrate intake than their less active peers, but all groups had similar protein, fat, saturated fat, monounsaturated fat, and polyunsaturated fat intakes.Conclusions. Intense training, but not low- to moderate-intensity physical activity, is associated with markedly lower levels of total and regional body fat in postmenopausal women. HRT has less of an effect on body composition than intense exercise training in postmenopausal women.
• Studies in biomimetic alkaloid syntheses. 14. Controlled, selective syntheses of catharanthine and tabersonine, and related desethyl compounds, through generation of 15-oxosecodine intermediates
  作者：Martin E. Kuehne、William G. Bornmann、William G. Earley、Istvan Marko

  DOI：10.1021/jo00365a012

  日期：1986.7
• Zelenin,K.N. et al., Doklady Chemistry, 1970, vol. 190, p. 161 - 164
  作者：Zelenin,K.N. et al.

  DOI：——

  日期：——
• Klimko,V.T. et al., Journal of general chemistry of the USSR, 1964, vol. 34, # 1, p. 108 - 112
  作者：Klimko,V.T. et al.

  DOI：——

  日期：——