(+/-)-cis-2-(2-hydroxyethyl)cyclopentanol | 62324-21-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-cis-2-(2-hydroxyethyl)cyclopentanol
• 英文别名: (+/-)-cis-2-(2-hydroxy-ethyl)-cyclopentanol；(+/-)-cis-2-(2-Hydroxy-aethyl)-cyclopentanol；(+/-)-1r-(2-Hydroxy-aethyl)-cyclopentanol-(2c)；(+/-)-cis-1-(2-Hydroxy-aethyl)-cyclopentanol-(2)；(+/-)cis-2-(2'-Hydroxyethyl)-cyclopentanol；(1S,2S)-2-(2-Hydroxyethyl)cyclopentan-1-ol；(1S,2S)-2-(2-hydroxyethyl)cyclopentan-1-ol
• CAS: 62324-21-4
• 化学式: C₇H₁₄O₂
• 分子量: 130.187
• InChiKey: GXCPYUDYGSGMCJ-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-cis-2-(2-hydroxyethyl)cyclopentanol 在 sodium sulfide 作用下， 以 吡啶 、 乙醇 、 水 为溶剂， 反应 14.0h， 生成 cis-2-thiabicyclo<3.3.0>octane
  参考文献：
  名称：

  Rao, R. R.; Sarkar, Rina; Bhattacharya, Sukla, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1987, vol. 26, # 1-12, p. 939 - 946

  摘要：

  DOI：
• 作为产物：
  描述：

  前列腺素中间体 生成 (+/-)-cis-2-(2-hydroxyethyl)cyclopentanol
  参考文献：
  名称：

  区域特异性和对映选择性的马肝醇脱氢酶催化某些羟基环戊烷的氧化。

  摘要：

  DOI：

  10.1021/ja00447a057

文献信息

• [EN] BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6<br/>[FR] INHIBITEURS DE BCL6 DÉRIVÉS DE BENZIMIDAZOLONE
  申请人：CANCER RESEARCH TECH LTD

  公开号：WO2018215801A1

  公开（公告）日：2018-11-29

  The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.

  本发明涉及作为BCL6（B细胞淋巴瘤6）活性抑制剂的Formula I化合物：其中X1、X2、R1、R2和R3如本文所定义。本发明还涉及制备这些化合物的方法，包括含有它们的药物组合物，以及它们在治疗增生性疾病（如癌症）以及BCL6活性有所涉及的其他疾病或病况中的用途。
• Regioselective silylation of 5-(2′-hydroxyethyl)cyclopent-2-en-1-ol and 6-(2′-hydroxyethyl)cyclohex-2-en-1-ol
  作者：Hao Chen、Erika Plettner

  DOI：10.1016/j.tetlet.2012.02.020

  日期：2012.4

  Herein we report regioselective and mild reactions for the tert-butyldimethylsilyl mono-protection of 5-(2′-hydroxyethyl)cyclopent-2-en-1-ol (2) and 6-(2′-hydroxyethyl)cycohex-2-en-1-ol (5) at the primary hydroxyl group or at the secondary allylic hydroxyl group. The different steric environment surrounding the secondary allylic and saturated primary alcohols is mainly invoked to rationalize the observed

  在这里，我们报告5-（2'-羟乙基）环戊-2-en-1-ol（2）和6-（2'-羟乙基）cyhehex-2-en对叔丁基二甲基甲硅烷基单保护的区域选择性反应和温和反应在伯羟基或仲烯丙基羟基上的-1-醇（5）。围绕仲烯丙基和饱和伯醇的不同空间环境主要是为了使观察到的区域选择性合理化。
• EFFICIENT INVERSIONS OF SECONDARY ALCOHOLS USING CESIUM ACETATE AND 18-CROWN-6
  作者：Yasuhiro Torisawa、Hiromitsu Okabe、Shiro Ikegami

  DOI：10.1246/cl.1984.1555

  日期：1984.9.5

  Reaction of alcohol mesylate with cesium acetate and 18-crown-6 in benzene is an effective method for the inversion of cyclopentyl and cyclohexyl alcohols.

  甲磺酸醇与乙酸铯和18-冠6在苯中反应是环戊醇和环己醇转化的有效方法。
• Synthesis of (R)-6,7-dihydro-5-HETE lactone and (S)-6,7-dihydro-5-HETE lactone by using novel yeast reduction as a key reaction
  作者：Satoshi Yamauchi、Kenji Takeda、Makoto Ganaha、Yoshiro Kinoshita

  DOI：10.1039/b206843p

  日期：2002.10.1

  Novel yeast reduction which gave (1R,2S)-hydroxy ester 10 and (1S,5S)-lactone 11 from racemic ketoester 12 was discovered. After 10 and 11 were converted to lactone 15 and 17, enantiomeric excesses were determined as 99% and 95%, respectively. This novel yeast reduction was applied to synthetic study of metabolites of 5-oxo-ETE 1. (R)-6,7-Dihydro-5-HETE lactone 5 and (S)-6,7-dihydro-5-HETE lactone 6 were synthesized from 15 and 17, respectively.

  新发现的酵母还原法可从外消旋酮酯 12 中得到（1R,2S）-羟基酯 10 和（1S,5S）-内酯 11。10 和 11 转化为内酯 15 和 17 后，对映体过量率分别为 99% 和 95%。(R)-6,7-Dihydro-5-HETE lactone 5 和 (S)-6,7-Dihydro-5-HETE lactone 6 分别由 15 和 17 合成。
• New Method for Synthesizing the Intermediates to 5-HETE from Yeast-mediated Reduction Products by Employing Baeyer-Villiger Oxidation with Complete Retention of Enantiomeric Excess
  作者：Satoshi YAMAUCHI、Yoshihiro KINOSHITA、Yoshiro KINOSHITA

  DOI：10.1271/bbb.67.1959

  日期：2003.1

  (R) and (S)-Aldehydes 2, which are intermediates for the synthesis of (5R) and (5S)-HETE, were respectively synthesized from the yeast-mediated reductive products, hydroxy ester 3 and cis-lactone 4, through Baeyer-Villiger oxidation with complete retention of enantiomeric excess.

  （R）和（S）-醛2是合成（5R）和（5S）-HETE的中间体，分别通过酵母介导的还原产物羟基酯3和顺式内酯4通过Baeyer合成-维利格氧化，完全保留对映体过量。