4-[4-(3-fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester | 1196484-96-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[4-(3-fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl 4-[4-(3-fluorophenoxy)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate
• CAS: 1196484-96-4
• 化学式: C₂₁H₂₄FN₅O₃
• 分子量: 413.452
• InChiKey: CYEGOKJXXNGPMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  82.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  tert-butyl 4-(4-chloro-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate 、 3-氟苯酚 以 N,N-二甲基甲酰胺 为溶剂， 生成 4-[4-(3-fluoro-phenoxy)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  GPR119 receptor agonists

  摘要：

  本文提供了式(I)的化合物及其药学上可接受的盐，其中取代基如规范中所披露。这些化合物及其含有的药物组合物，对于代谢性疾病和紊乱的治疗是有用的，例如II型糖尿病。

  公开号：

  US08188098B2

文献信息

• GPR119 Receptor Agonists
  申请人：Erickson Shawn David

  公开号：US20090286812A1

  公开（公告）日：2009-11-19

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.

  提供以下公式(I)的化合物： 以及可药用的接受盐，其中取代基如说明书中所披露。这些化合物以及含有它们的药物组合物可用于治疗代谢性疾病和障碍，例如，2型糖尿病。
• GPR119 RECEPTOR AGONISTS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2283019A1

  公开（公告）日：2011-02-16
• CELLULOSE ACYLATE FILM AND METHOD FOR PRODUCING SAME, POLARIZING PLATE, RETARDATION FILM, OPTICAL COMPENSATORY FILM, ANTI-REFLECTION FILM, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：Hashimoto Kiyokazu

  公开号：US20090036667A1

  公开（公告）日：2009-02-05

  A cellulose acylate film is stretched in the longitudinal direction by 1-300% under such conditions that the ration of the stretching distance (L) to the width (W) of the film before stretching, i.e., length/width ratio (L/W), is higher than 0.01 and lower than 0.3. The film stretched is relaxed in the longitudinal direction by 1-50% to produce a cellulose acylate film. When this film is incorporated in a liquid-crystal display, it can prevent the occurrence of color unevenness even when used in an high-temperature high-humidity atmosphere.
• US8188098B2
  申请人：——

  公开号：US8188098B2

  公开（公告）日：2012-05-29
• [EN] GPR119 RECEPTOR AGONISTS<br/>[FR] AGONISTES DES RÉCEPTEURS DE GPR119
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009141238A1

  公开（公告）日：2009-11-26

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.