(2S,3R,4S,5R)-2-ethoxy-5-(hydroxymethyl)oxolane-3,4-diol | 1472063-31-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5R)-2-ethoxy-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 1472063-31-2
• 化学式: C₇H₁₄O₅
• 分子量: 178.185
• InChiKey: XESKOQZTIQOBMT-GBNDHIKLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙醇 、 卡培他滨杂质25 在 四溴化碳 、 三苯基膦 作用下， 反应 16.0h， 以60%的产率得到
  参考文献：
  名称：

  Organocatalyzed Direct Glycosylation of Unprotected and Unactivated Carbohydrates

  摘要：

  Organocatalyzed direct glycosylation of unprotected and unactivated carbohydrates is reported. This process is catalyzed by triphenylphosphine and tetrabromomethane at room temperature under neutral conditions. With this operationally simple protocol thermodynamically favored, glycosides were obtained in a very straightforward reaction.

  DOI：

  10.1021/ol402914v

文献信息

• US4914233A
  申请人：——

  公开号：US4914233A

  公开（公告）日：1990-04-03
• Organocatalyzed Direct Glycosylation of Unprotected and Unactivated Carbohydrates
  作者：Sebastian Schmalisch、Rainer Mahrwald

  DOI：10.1021/ol402914v

  日期：2013.11.15

  Organocatalyzed direct glycosylation of unprotected and unactivated carbohydrates is reported. This process is catalyzed by triphenylphosphine and tetrabromomethane at room temperature under neutral conditions. With this operationally simple protocol thermodynamically favored, glycosides were obtained in a very straightforward reaction.