2-异丙基-5-甲基己醛 | 66656-67-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-异丙基-5-甲基己醛
• 英文名称: 2.6-dimethyl-3-formyl-heptane
• 英文别名: 2-Isopropyl-3-isobutyl-propionaldehyd；2.6-Dimethyl-3-formyl-heptan；2.6-Dimethyl-3-methylal-heptan；Isopropyl-isoamyl-acetaldehyd；2-isopropyl-5-methyl-heptanal；2-isopropyl-5-methylhexanal；5-methyl-2-propan-2-ylhexanal
• CAS: 66656-67-5
• 化学式: C₁₀H₂₀O
• 分子量: 156.268
• InChiKey: STZPMOIAPWTLNJ-UHFFFAOYSA-N

物化性质

• 沸点：
  192.4±8.0 °C(Predicted)
• 密度：
  0.813±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2912190090

反应信息

• 作为反应物：
  描述：

  2-异丙基-5-甲基己醛 在 lithium aluminium tetrahydride 、 palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 生成 4-isopropyl-7-methyl-octan-1-ol
  参考文献：
  名称：

  [EN] BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  [FR] LIPIDES BIODÉGRADABLES POUR L'ADMINISTRATION D'AGENTS ACTIFS

  摘要：

  本发明涉及一种阳离子脂质，其中在阳离子脂质的脂质部分（例如，疏水链）中具有一个或多个可生物降解的基团。这些阳离子脂质可以掺入脂质粒子中，用于递送一种活性剂，例如核酸。本发明还涉及包含中性脂质、能够减少聚集的脂质、本发明的阳离子脂质以及可选的甾醇的脂质粒子。脂质粒子还可以进一步包括治疗剂，例如核酸。

  公开号：

  WO2013086354A1
• 作为产物：
  描述：

  可可醛 生成 2-异丙基-5-甲基己醛
  参考文献：
  名称：

  Fischer; Loewenberg, Justus Liebigs Annalen der Chemie, 1932, vol. 494, p. 283

  摘要：

  DOI：

文献信息

• Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof
  申请人：Gao Mingzhi

  公开号：US20050239636A1

  公开（公告）日：2005-10-27

  The present invention provides a solid catalyst component for the polymerization of olefins, comprising magnesium, titanium, a halogen and an electron donor, wherein said electron donor comprises at least one selected from the group consisting of polyol ester compounds of the formula (I): R 1 CO—O—CR 3 R 4 -A-CR 5 R 6 —O—CO—R 2 (I) wherein, R 1 and R 2 groups, which may be identical or different, can be substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R 3 -R 6 groups, which may be identical or different, can be selected from the group consisting of hydrogen, halogen or substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R 1 -R 6 groups optionally contain one or more hetero-atoms replacing carbon, hydrogen atom or the both, said hetero-atom is selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus and halogen atom, two or more of R 3 -R 6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring; A is a single bond or bivalent linking group with chain length between two free radicals being 1-10 atoms, wherein said bivalent linking group is selected from the group consisting of aliphatic, alicyclic and aromatic bivalent radicals, and can carry C 1 -C 20 linear or branched substituents; one or more of carbon atom and/or hydrogen atom on above-mentioned bivalent linking group and substituents can be replaced by a hetero-atom selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus, and halogen atom, and two or more said substituents on the linking group as well as above-mentioned R 3 -R 6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring.

  本发明提供了一种用于烯烃聚合的固体催化剂组分，包括镁、钛、卤素和电子给体，其中所述电子给体包括以下至少一种选择自聚醇酯化合物组的化合物（I）：R1CO—O—CR3R4-A-CR5R6—O—CO—R2（I）其中，R1和R2基团可以相同或不同，可以是取代或未取代的1至20个碳原子的烃基，R3-R6基团可以相同或不同，可以选择自氢、卤素或取代或未取代的1至20个碳原子的烃基的群组中，R1-R6基团可以选用一个或多个杂原子代替碳、氢原子或两者，所述杂原子选择自氮、氧、硫、硅、磷和卤素原子的群组，R3-R6基团中的两个或更多个可以连接形成饱和或不饱和的单环或多环环；A是单键或双价连接基团，链长在两个自由基之间为1-10个原子，其中所述双价连接基团选自脂肪族、环脂族和芳香族双价基团的群组，可以携带C1-C20线性或支链取代基；上述双价连接基团和取代基上的一个或多个碳原子和/或氢原子可以被选择自氮、氧、硫、硅、磷和卤素原子的群组中的杂原子取代，两个或更多所述取代基在连接基团上以及上述R3-R6基团中可以连接形成饱和或不饱和的单环或多环环。
• Polyol ester compounds useful in preparation of a catalyst for olefins polymerization, process for preparing the same and use thereof
  申请人：Gao Mingzhi

  公开号：US20050096389A1

  公开（公告）日：2005-05-05

  The present application relates to polyol ester compounds, having general formula (I): R 1 CO—O—CR 3 R4-A-CR 5 R 6 —O—CO—R 2 (I) wherein, R, and R 2 groups, which may be identical or different, can be substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R 3 -R 6 groups, which may be identical or different, can be selected from the group consisting of hydrogen, halogen or substituted or unsubstituted hydrocarbyl having 1 to 20 carbon atoms, R 1 -R 6 groups optionally contain one or more hetero-atoms replacing carbon, hydrogen atom or the both, said hetero-atom is selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus and halogen atom, two or more of R 3 -R 6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring; A is a single bond or bivalent linking group with chain length between two free radicals being 1-10 atoms, wherein said bivalent linking group is selected from the group consisting of aliphatic, alicyclic and aromatic bivalent radicals, and can carry C 1 -C 20 linear or branched substituents; one or more of carbon atom and/or hydrogen atom on the substituents can be replaced by a hetero-atom selected from the group consisting of nitrogen, oxygen, sulfur, silicon, phosphorus, and halogen atom, and two or more said substituents on the linking group as well as above-mentioned R 3 -R 6 groups can be linked to form saturated or unsaturated monocyclic or polycyclic ring. The compounds of formula (I) find use in preparing a catalyst for olefin polymerization.

  本申请涉及聚醇酯化合物，其一般式为（I）：R1CO-O-CR3R4-A-CR5R6-O-CO-R2（I），其中，R和R2基团可以相同或不同，可以是取代或未取代的碳氢基，其碳原子数为1到20个；R3-R6基团可以相同或不同，可以选择来自氢、卤素或取代或未取代的碳氢基的群，R1-R6基团可以选择包含一个或多个取代碳、氢原子或两者的杂原子，所述杂原子选择来自氮、氧、硫、硅、磷和卤素原子的群，其中R3-R6中的两个或更多个可以连接以形成饱和或不饱和的单环或多环环；A是单键或双价连接基团，其链长在两个自由基之间为1-10个原子，在所述双价连接基团中选择来自脂肪族、环烷和芳香族双价基团的群，并且可以携带C1-C20线性或支链取代基；取代基上的一个或多个碳原子和/或氢原子可以被选择来自氮、氧、硫、硅、磷和卤素原子的群的杂原子所取代，连接基上的两个或更多个取代基以及上述R3-R6基团可以连接以形成饱和或不饱和的单环或多环环。式（I）化合物可用于制备用于烯烃聚合的催化剂。
• Method for producing 6-methylheptane-2-one and the use thereof
  申请人：——

  公开号：US20040249218A1

  公开（公告）日：2004-12-09

  Process for preparing 6-methylheptan-2-one, which comprises a) hydroformylation of isobutene to form 3-methylbutanal, b) base-catalyzed aldol condensation of the 3-methylbutanal with acetone to form 6-methylhept-3-en-2-one, with the molar ratio of 3-methylbutanal to the base used being more than 1:0.3 and c) hydrogenation of the 6-methylhept-3-en-2-one to give 6-methylheptan-2-one. The use of the 6-methylheptan-2-one prepared in this way for the preparation of isophytol, tetrahydrolinalool or dihydrogeraniol.

  制备6-甲基庚酮的过程，包括a) 对异丁烯进行氢甲酰化反应，形成3-甲基丁醛，b) 将3-甲基丁醛与丙酮进行碱催化的羟醛缩合反应，形成6-甲基庚-3-烯-2-酮，其中3-甲基丁醛与所使用的碱的摩尔比大于1:0.3，c) 对6-甲基庚-3-烯-2-酮进行加氢反应，得到6-甲基庚酮。用这种方法制备的6-甲基庚酮可用于制备异飞兰醇、四氢芳樟醇或双氢佐伯醇。
• USE OF 2-ISOPROPYL-2-ALKYL-1,3-PROPANEDIOLS FOR PREPARING POLYMERS
  申请人：Mijolovic Darijo

  公开号：US20110124809A1

  公开（公告）日：2011-05-26

  Polymer obtainable by polycondensation or polyadduct formation from monomeric compounds, wherein accompanying use is made as monomeric compound of 2-isopropyl-2-alkyl-1,3-propanediols of the formula I or alkoxylated derivatives thereof.

  可以通过聚缩合或聚加成形从单体化合物中获得的聚合物，其中2-异丙基-2-烷基-1,3-丙二醇（式I）或其烷氧基衍生物被用作单体化合物。
• BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20130195920A1

  公开（公告）日：2013-08-01

  The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

  本发明涉及一种带有一个或多个可生物降解基团的阳离子脂质，该基团位于脂质部分（如疏水链）内。这些阳离子脂质可以被纳入脂质粒中，以传递活性物质，例如核酸。本发明还涉及包括中性脂质、能够减少聚集的脂质、本发明中的阳离子脂质以及可选的甾醇的脂质粒。该脂质粒还可以进一步包括治疗剂，例如核酸。