5-(4-Hydroxybut-1-ynyl)oxolan-2-one | 1338347-33-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 5-(4-Hydroxybut-1-ynyl)oxolan-2-one
• 英文别名: 5-(4-hydroxybut-1-ynyl)oxolan-2-one
• CAS: 1338347-33-3
• 化学式: C₈H₁₀O₃
• 分子量: 154.166
• InChiKey: RXMXYEGWGNNIBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-(4-Hydroxybut-1-ynyl)oxolan-2-one 在 Zeise's dimer 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 正己烷 为溶剂， 23.0 ℃ 、101.33 kPa 条件下， 反应 1.25h， 生成 4-(2-Furyl)buttersaeure-methylester
  参考文献：
  名称：

  Generation of α,β-Unsaturated Platinum Carbenes from Homopropargylic Alcohols: Rearrangements to Polysubstituted Furans

  摘要：

  A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.

  DOI：

  10.1021/ol202649j
• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 以50%的产率得到5-(4-Hydroxybut-1-ynyl)oxolan-2-one
  参考文献：
  名称：

  Generation of α,β-Unsaturated Platinum Carbenes from Homopropargylic Alcohols: Rearrangements to Polysubstituted Furans

  摘要：

  A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.

  DOI：

  10.1021/ol202649j

文献信息

• Generation of α,β-Unsaturated Platinum Carbenes from Homopropargylic Alcohols: Rearrangements to Polysubstituted Furans
  作者：Paul A. Allegretti、Eric M. Ferreira

  DOI：10.1021/ol202649j

  日期：2011.11.4

  A number of diversely substituted furans are synthesized via a cycloisomerization process that goes through a unique metal carbene species. Both ligand structure and the nature of the leaving group are evaluated. The characteristics of the carbene intermediate can be modulated, resulting in highly selective hydrogen or silicon group migrations.