1,6-Dioxaspiro[4.4]nona-3,8-diene | 174307-63-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,6-Dioxaspiro[4.4]nona-3,8-diene
• CAS: 174307-63-2
• 化学式: C₇H₈O₂
• 分子量: 124.139
• InChiKey: AWGWZZTXMLVKLT-UHFFFAOYSA-N

物化性质

• 沸点：
  192.6±40.0 °C(Predicted)
• 密度：
  1.16±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-Dioxaspiro[4.4]nona-3,8-diene 在 对甲苯磺酸 作用下， 反应 1.0h， 生成 (E)-3-(2-furanyl)-2-propen-1-ol
  参考文献：
  名称：

  Spirocycle assembly through selective tandem ring closing metathesis reactions

  摘要：

  A range of functionalised spirocyclic systems have been prepared under mild and neutral conditions by tandem selective ring closing olefin metathesis reactions. Additionally, a marked preference for 5-membered ring closure over 7-membered ring closure was observed which appears to be a result of a kinetically favoured cyclisation process. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00375-5
• 作为产物：
  描述：

  2,2-Bis(ethenyl)-4,7-dihydro-1,3-dioxepine 在 Grubbs catalyst first generation 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 以50%的产率得到1,6-Dioxaspiro[4.4]nona-3,8-diene
  参考文献：
  名称：

  Spirocycle assembly through selective tandem ring closing metathesis reactions

  摘要：

  A range of functionalised spirocyclic systems have been prepared under mild and neutral conditions by tandem selective ring closing olefin metathesis reactions. Additionally, a marked preference for 5-membered ring closure over 7-membered ring closure was observed which appears to be a result of a kinetically favoured cyclisation process. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00375-5

文献信息

• Spirocycle assembly through selective tandem ring closing metathesis reactions
  作者：Martin J. Bassindale、Peter Hamley、Andreas Leitner、Joseph P.A. Harrity

  DOI：10.1016/s0040-4039(99)00375-5

  日期：1999.4

  A range of functionalised spirocyclic systems have been prepared under mild and neutral conditions by tandem selective ring closing olefin metathesis reactions. Additionally, a marked preference for 5-membered ring closure over 7-membered ring closure was observed which appears to be a result of a kinetically favoured cyclisation process. (C) 1999 Elsevier Science Ltd. All rights reserved.