1-phenyl-3-(phenylsulfonyl)-1H-pyrrole | 117113-18-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-phenyl-3-(phenylsulfonyl)-1H-pyrrole
• 英文别名: 3-(Benzenesulfonyl)-1-phenylpyrrole
• CAS: 117113-18-5
• 化学式: C₁₆H₁₃NO₂S
• 分子量: 283.351
• InChiKey: ZJIFGBVBVREQPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯亚磺酸 、 N-(but-3-yn-1-yl)aniline 在 亚硝酸特丁酯 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 10.0h， 以46%的产率得到1-phenyl-3-(phenylsulfonyl)-1H-pyrrole
  参考文献：
  名称：

  tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids

  摘要：

  tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.

  DOI：

  10.1021/acs.joc.8b00741

文献信息

• Croce, Piero Dalla; Gariboldi, Pierluigi; La Rosa, Concetta, Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 1793 - 1798
  作者：Croce, Piero Dalla、Gariboldi, Pierluigi、La Rosa, Concetta

  DOI：——

  日期：——
• DALLA, CROCE PIERO;GARIBOLDI, PIERLUIGI;LA, ROSA CONCETTA, J. HETEROCYCL. CHEM., 24,(1987) N 6, 1793-1797
  作者：DALLA, CROCE PIERO、GARIBOLDI, PIERLUIGI、LA, ROSA CONCETTA

  DOI：——

  日期：——
• <i>tert</i>-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids
  作者：Zhenjie Qi、Yong Jiang、Yanyan Wang、Rulong Yan

  DOI：10.1021/acs.joc.8b00741

  日期：2018.8.3

  tert-Butyl nitrite promoted oxidative intermolecular sulfonamination of alkynes to synthesize substituted sulfonyl pyrroles from the alkynylamines and sulfinic acids via tandem addition/cyclization was developed. This reaction is performed well by employing tert-butyl nitrite as the oxidant, and various substituted sulfonyl pyrroles are formed in moderate to good yields with no requirement of metal catalysis.