1-n-butoxy-3-iso-propoxy-2-propanol | 53146-43-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 1-n-butoxy-3-iso-propoxy-2-propanol
• 英文别名: 1-n-butoxy-3-isopropoxy-2-propanol；1-butoxy-3-isopropoxypropan-2-ol；1-Isopropyloxy-3-butoxy-2-propanol；1-Butoxy-3-propan-2-yloxypropan-2-ol
• CAS: 53146-43-3
• 化学式: C₁₀H₂₂O₃
• 分子量: 190.283
• InChiKey: KXPFLEJLEPRBNF-UHFFFAOYSA-N

物化性质

• 沸点：
  223 °C
• 密度：
  0.9084 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异丙基缩水甘油醚 、 sodium butanolate 在 水 作用下， 以 正丁醇 为溶剂， 反应 0.5h， 生成 1-n-butoxy-3-iso-propoxy-2-propanol
  参考文献：
  名称：

  绿色的 溶剂 从 甘油。烷基甘油醚的合成及其理化性质

  摘要：

  一个家庭 甘油 合成了由六十多个在末端位置对称和不对称取代的1,3-二烷氧基-2-丙醇和1,2,3-三烷氧基丙烷组成的衍生物，这些衍生物的可能作用 甘油 衍生品替代 溶剂已通过测量其理化性质进行了评估。制备的衍生物的分子多样性会导致极性性质发生显着变化，从而有助于确定可能的候选物。溶剂 代换。

  DOI：

  10.1039/b923631g

文献信息

• Readily Scalable Methodology for the Synthesis of Nonsymmetric Glyceryl Diethers by a Tandem Acid-/Base-Catalyzed Process
  作者：Alejandro Leal-Duaso、Sara Gracia-Barberán、José A. Mayoral、José I. García、Elisabet Pires

  DOI：10.1021/acs.oprd.9b00411

  日期：2020.2.21

  A useful optimized synthetic methodology has been designed for the synthesis of nonsymmetric glyceryl diethers from epichlorohydrin. A tandem process combining a cheap, heterogeneous, and fully recoverable acid catalyst and alkaline hydroxide is used for the synthesis of a variety of glycerol-derived ethers bearing different alkyl substituents in 1 and 3 positions. Different heterogeneous acid catalysts

  已经设计了一种有用的优化合成方法，用于从表氯醇合成非对称甘油二醚。将廉价，多相且可完全回收的酸催化剂与碱性氢氧化物结合使用的串联方法可用于合成多种甘油衍生的醚，这些醚在1和3位带有不同的烷基取代基。对于表氯醇与几种醇的反应，已经测试了不同的非均相酸催化剂，使用易于获得的可回收且廉价的蒙脱土K10和Nafion NR50可获得最佳结果。对于第二反应步骤，使用氢氧化钾。在所有情况下，都能在平稳的反应条件下获得所需的甘油二醚的良好收率，始终具有表氯醇的总转化率，而无需中间纯化。串联工艺的规模放大已经取得了良好的结果。
• SILICA SULFURIC ACID; AN EFFICIENT AND REUSABLE CATALYST FOR REGIOSELECTIVE RING OPENING OF EPOXIDES BY ALCOHOLS AND WATER
  作者：Peyman Salehi、Minoo Dabiri、Ali Zolfigol、Ali Bodaghi Fard

  DOI：10.1080/10426500490459722

  日期：2004.6

  The nucleophilic ring opening reactions of epoxides by aliphatic alcohols and water are achieved efficiently in the presence of catalytic amounts of silica sulfuric acid with high degree of regioselectivity. The catalyst is reusable and can be applied several times without any decrease in the yield of reactions.

  脂肪醇和水对环氧化物的亲核开环反应在催化量的具有高度区域选择性的二氧化硅硫酸的存在下有效地实现。该催化剂可重复使用，可多次使用而不会降低反应产率。
• Iron Perchlorate on Silica Gel as Multi-purpose Reagent for Catalysis of Closure and Rupture of Carbon-Oxygen Bond in Epoxides, Alcohols, and Esters
  作者：P. Salechi、M. M. Khodaei、S. B. Ghareghani、A. R. Motlagh

  DOI：10.1023/b:rujo.0000003154.92028.84

  日期：2003.6

  Aliphatic alcohols and water in the presence of catalytic amounts of Fe3+ ion introduced as iron(Ill) perchlorate on silica gel carrier perform efficient regiospecific opening of an epoxy ring. Carbon acids esterification with various type alcohols was carried out using the system Fe(ClO4)(3)-silica gel in dichloromethane under conditions excluding solvolysis. Acetylation and formylation of alcohols was performed by efficient transesterification with ethyl acetate and ethyl formate.
• Magnesium Hydrogensulfate: A Cheap and Efficient Catalyst for the Conversion of Epoxides into β-Alkoxy Alcohols, Vicinal-Diols, and Thiiranes
  作者：Peyman Salehi、Mohammad Mahdi Khodaei、Mohammad Ali Zolfigol、Afsaneh Keyvan

  DOI：10.1081/scc-120022479

  日期：2003.9.1

  The nucleophilic ring opening reactions of epoxides by aliphatic alcohols and water are achieved efficiently in the presence of catalytic amounts of magnesium hydrogensulfate, Mg(HSO4)(2), with high degree of regioselectivity. The reactions are chemoselective and many of the other functional groups such as ethereal carbon-oxygen bonds as well as carbon-carbon double bond remain intact under the reaction conditions. Epoxides also react with thiourea or ammonium thiocyanate in the presence of Mg(HSO4)(2) to afford the corresponding thiiranes in good to excellent yields.