1,1,2,2-tetrafluoro-5-phenyl-5-amino-4-penten-3-one | 123824-65-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1,1,2,2-tetrafluoro-5-phenyl-5-amino-4-penten-3-one
• 英文别名: (Z)-1-amino-4,4,5,5-tetrafluoro-1-phenylpent-1-en-3-one
• CAS: 123824-65-7
• 化学式: C₁₁H₉F₄NO
• 分子量: 247.192
• InChiKey: PHSVSNJYJACRLK-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,2,2-tetrafluoro-5-phenyl-5-amino-4-penten-3-one 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 4,4,5,5-四氟-1-苯基戊烷-1,3-二酮 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Hydrolysis of fluoroalkyl-containing ?-aminovinyl ketones

  摘要：

  The kinetics of hydrolysis of fluoroalkyl-containing beta-aminovinyl ketones R1C(O)CHC(NHR3)R2, in which the substituents CF3 and HCF2CF2 are in the ketone (R1) or enamine parts of the molecule (R2), was studied. In acid (pH < 5) and alkaline (pH > 10) media, they hydrolyze with the formation of the corresponding amines and beta-diketones. In an alkaline medium, the beta-diketones undergo cleavage to fluorinated acids and methyl ketones. The rate constants of hydrolysis in an acid medium change within a range of four orders, depending on the nature of the substituents. The presence of a fluoroalkyl group at the enamine reaction center increases the hydrolysis rate. In an alkaline medium, the rate constants vary within one order.

  DOI：

  10.1007/bf00957999
• 作为产物：
  描述：

  4,4,5,5-四氟-1-苯基戊烷-1,3-二酮 在 碳酸氢铵 作用下， 以 甲醇 为溶剂， 以61%的产率得到1-phenyl-4,4,5,5-tetrafluoro-3-aminopenten-1-one
  参考文献：
  名称：

  Karpenko; Filyakova; Pashkevich, Russian Journal of Organic Chemistry, 1997, vol. 33, # 12, p. 1724 - 1726

  摘要：

  DOI：

文献信息

• Interaction of fluoroalkyl-containing ?-diketones with amines
  作者：V. I. Filyakova、Y. G. Ratner、N. S. Karpenko、K. I. Pashkevich

  DOI：10.1007/bf01430731

  日期：1996.9

  The composition of products of the interaction of asymmetric fluoroalkyl-containing beta-diketones with amines was studied. Mixtures of regioisomeric beta-aminovinylketones and products of cleavage and secondary condensation are formed, depending on the temperature, the solvent, the nature of the fluorinated and nonfluorinated substituents in the beta-diketone, and the basicity of the amine. The major product is a beta-aminovinylketone in which the NH2 group is removed from the fluoroalkyl substituent. No beta-aminovinylimines, products of condensation involving two electrophilic centers, were observed.
• Saloutin, V. I.; Burgart, Ya. V.; Skryabina, Z. E., Russian Journal of Organic Chemistry, 1995, vol. 31, # 1.1, p. 49 - 51
  作者：Saloutin, V. I.、Burgart, Ya. V.、Skryabina, Z. E.、Filyakova, V. I.

  DOI：——

  日期：——
• BAZHENOVA, L. N.;FILYAKOVA, V. I.;KIRICHENKO, V. E.;PASHKEVICH, K. I., IZV. AN CCCP. CEP. XIM.,(1991) N, S. 664-669
  作者：BAZHENOVA, L. N.、FILYAKOVA, V. I.、KIRICHENKO, V. E.、PASHKEVICH, K. I.

  DOI：——

  日期：——
• PASHKEVICH, K. I.;FILYAKOVA, V. I.;POSTOVSKIJ, I. YA., IZV. AN CCCP. CEP. XIM., 1981, N 10, 2346-2349
  作者：PASHKEVICH, K. I.、FILYAKOVA, V. I.、POSTOVSKIJ, I. YA.

  DOI：——

  日期：——
• Karpenko; Filyakova; Pashkevich, Russian Journal of Organic Chemistry, 1997, vol. 33, # 12, p. 1724 - 1726
  作者：Karpenko、Filyakova、Pashkevich

  DOI：——

  日期：——