1-(3-methoxyphenyl)-2-(quinolin-2-yl)ethanol | 1313239-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(3-methoxyphenyl)-2-(quinolin-2-yl)ethanol
• 英文别名: 1-(3-Methoxyphenyl)-2-quinolin-2-ylethanol
• CAS: 1313239-93-8；1450604-95-1
• 化学式: C₁₈H₁₇NO₂
• 分子量: 279.338
• InChiKey: FDIIEZOHEWNRMO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  42.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲基喹啉 、 3-甲氧基苯甲醛 以 水 为溶剂， 反应 0.5h， 以65%的产率得到1-(3-methoxyphenyl)-2-(quinolin-2-yl)ethanol
  参考文献：
  名称：

  Microwave assisted water mediated benzylic C–H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes

  摘要：

  A highly efficient method is described for the sp(3) C-H bond functionalization of methyl aza-arenes in the presence of water under microwave irradiation and subsequent addition to aromatic aldehydes. This transformation represents an efficient way to synthesize 2-alkyl aza-arene derivatives from simple starting materials. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.053

文献信息

• Microwave assisted water mediated benzylic C–H functionalization of methyl aza-arenes and nucleophilic addition to aromatic aldehydes
  作者：N. Nageswara Rao、H.M. Meshram

  DOI：10.1016/j.tetlet.2013.07.053

  日期：2013.9

  A highly efficient method is described for the sp(3) C-H bond functionalization of methyl aza-arenes in the presence of water under microwave irradiation and subsequent addition to aromatic aldehydes. This transformation represents an efficient way to synthesize 2-alkyl aza-arene derivatives from simple starting materials. (C) 2013 Elsevier Ltd. All rights reserved.