1-[4-[[4-(Benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]phenyl]sulfonyl-3-butylurea | 1380783-56-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[4-[[4-(Benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]phenyl]sulfonyl-3-butylurea
• CAS: 1380783-56-1
• 化学式: C₁₉H₂₀N₄O₈S₂
• 分子量: 496.522
• InChiKey: YDQMWLIBRNKVLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  187
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  4-(3-phenylsulfonylfuroxan-4-yloxy)benzenesulfonamide 、 异氰酸正丁酯 在 copper(l) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以15%的产率得到1-[4-[[4-(Benzenesulfonyl)-5-oxido-1,2,5-oxadiazol-5-ium-3-yl]oxy]phenyl]sulfonyl-3-butylurea
  参考文献：
  名称：

  Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues

  摘要：

  We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic beta-cells and in vitro vasodilator and anti-aggregatory activities, is reported. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.03.103

文献信息

• Synthesis and preliminary biological profile of new NO-donor tolbutamide analogues
  作者：Yasinalli Tamboli、Loretta Lazzarato、Elisabetta Marini、Stefano Guglielmo、Michela Novelli、Pascale Beffy、Pellegrino Masiello、Roberta Fruttero、Alberto Gasco

  DOI：10.1016/j.bmcl.2012.03.103

  日期：2012.6

  We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic beta-cells and in vitro vasodilator and anti-aggregatory activities, is reported. (C) 2012 Elsevier Ltd. All rights reserved.