(E)-1-(4-methoxystyryl)-4-phenyl-1H-imidazole | 1233718-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (E)-1-(4-methoxystyryl)-4-phenyl-1H-imidazole
• 英文别名: 1-[(E)-2-(4-methoxyphenyl)ethenyl]-4-phenylimidazole
• CAS: 1233718-78-9
• 化学式: C₁₈H₁₆N₂O
• 分子量: 276.338
• InChiKey: UKTOQZMFMFUVFX-VAWYXSNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-((E)-2-溴乙烯基)-4-甲氧基苯 、 4-苯基咪唑 在 copper(II) oxide 、 potassium hydroxide 作用下， 以 二甲基亚砜 为溶剂， 反应 11.0h， 以84%的产率得到(E)-1-(4-methoxystyryl)-4-phenyl-1H-imidazole
  参考文献：
  名称：

  Copper oxide nanoparticles catalyzed vinylation of imidazoles with vinyl halides under ligand-free conditions

  摘要：

  Recyclable copper oxide nanoparticles catalyzed most efficient and straightforward protocol for the vinylation of imidazoles with vinyl halides under ligand-free conditions. Utilizing this protocol various imidazoles were cross-coupled with different substituted vinyl halides to get the corresponding products in excellent yields with the retention configuration. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.04.022

文献信息

• Copper oxide nanoparticles catalyzed vinylation of imidazoles with vinyl halides under ligand-free conditions
  作者：V. Prakash Reddy、A. Vijay Kumar、K. Rama Rao

  DOI：10.1016/j.tetlet.2010.04.022

  日期：2010.6

  Recyclable copper oxide nanoparticles catalyzed most efficient and straightforward protocol for the vinylation of imidazoles with vinyl halides under ligand-free conditions. Utilizing this protocol various imidazoles were cross-coupled with different substituted vinyl halides to get the corresponding products in excellent yields with the retention configuration. (C) 2010 Elsevier Ltd. All rights reserved.