methyl (2-(4-benzoyl-1H-pyrrol-3-yl)-4-bromophenyl)carbamate | 1421605-64-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl (2-(4-benzoyl-1H-pyrrol-3-yl)-4-bromophenyl)carbamate
• 英文别名: methyl N-[2-(4-benzoyl-1H-pyrrol-3-yl)-4-bromophenyl]carbamate
• CAS: 1421605-64-2
• 化学式: C₁₉H₁₅BrN₂O₃
• 分子量: 399.244
• InChiKey: QGVMJTDMTGPGEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  71.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 5-bromo-3-(2-oxo-2-phenylethylidene)indolin-2-one 、 4-甲苯磺酰乙腈 在 potassium tert-butylate 作用下， 反应 4.0h， 以67%的产率得到methyl (2-(4-benzoyl-1H-pyrrol-3-yl)-4-bromophenyl)carbamate
  参考文献：
  名称：

  3-Phenacylideneoxindoles with tosylmethyl isocyanide and MeOH through C–C bond cleavage: facile synthesis of pyrrole and 2H-pyrrolo[3,4-c]quinoline derivatives

  摘要：

  A novel reaction of 3-phenacylideneoxindoles (1) with tosylmethyl isocyanide (2a) and MeOH through C-C bond cleavage has been developed. The reaction proceeded under mild conditions, providing a powerful synthetic tool for the construction of pyrrole derivatives (3) from easily accessible starting materials and synthesis of 2H-pyrrolo[3,4-c]quinolines (4) by further dehydration of 3. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.11.088

文献信息

• 3-Phenacylideneoxindoles with tosylmethyl isocyanide and MeOH through C–C bond cleavage: facile synthesis of pyrrole and 2H-pyrrolo[3,4-c]quinoline derivatives
  作者：Rong Wang、Xiao-Ping Xu、Hua Meng、Shun-Yi Wang、Shun-Jun Ji

  DOI：10.1016/j.tet.2012.11.088

  日期：2013.2

  A novel reaction of 3-phenacylideneoxindoles (1) with tosylmethyl isocyanide (2a) and MeOH through C-C bond cleavage has been developed. The reaction proceeded under mild conditions, providing a powerful synthetic tool for the construction of pyrrole derivatives (3) from easily accessible starting materials and synthesis of 2H-pyrrolo[3,4-c]quinolines (4) by further dehydration of 3. (C) 2012 Elsevier Ltd. All rights reserved.