(3-(4-chlorophenyl)thiophene-2,5-diyl)bis((4-chlorophenyl)methanone) | 1159998-83-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3-(4-chlorophenyl)thiophene-2,5-diyl)bis((4-chlorophenyl)methanone)
• 英文别名: [3-(4-chlorophenyl)thiophene-2,5-diyl]bis[(4-chlorophenyl)methanone]；[3-(4-chlorophenyl)thiene-2,5-diyl]bis[(4-chlorophenyl)methanone]；[5-(4-Chlorobenzoyl)-4-(4-chlorophenyl)thiophen-2-yl]-(4-chlorophenyl)methanone；[5-(4-chlorobenzoyl)-4-(4-chlorophenyl)thiophen-2-yl]-(4-chlorophenyl)methanone
• CAS: 1159998-83-0
• 化学式: C₂₄H₁₃Cl₃O₂S
• 分子量: 471.791
• InChiKey: NOPGAXPJIWWGIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2'-溴-4-氯苯乙酮 在 sodium sulfide 、 十六烷基三甲基溴化铵 、 sodium iodide 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙醇 、 水 为溶剂， 反应 1.5h， 以67%的产率得到(3-(4-chlorophenyl)thiophene-2,5-diyl)bis((4-chlorophenyl)methanone)
  参考文献：
  名称：

  An Aquatic Pseudo-Four-Component Reaction for the Synthesis of Highly Substituted Thiophenes

  摘要：

  A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of alpha-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and sodium iodide in aqueous ethanol under aerobic conditions. A mechanism for the reaction is proposed.

  DOI：

  10.1055/s-0032-1316866

文献信息

• Selenium dioxide reaction of substituted diphenacyl sulfides: generation of α -ketoacids
  作者：Muthupandi Nagaraj、Devanathan Perumal、Muthusamy Boominathan、Shanmugam Muthusubramanian、Nattamai Bhuvanesh

  DOI：10.1080/17415993.2013.769542

  日期：2014.1.2

  The attempted selenium dioxide oxidation of substituted diphenacyl sulfides in anticipation of further functionalization led to a series of α -ketoacids 3 via oxidation followed by C‒S bond cleavage. Two minor products, 5 and 6, have also been isolated and a mechanistic pathway for the formation of 3, 5 and 6 has been proposed. GRAPHICAL ABSTRACT

  取代二苯甲酰硫醚的二氧化硒氧化预期进一步功能化导致一系列 α-酮酸 3 通过氧化随后 C-S 键断裂。还分离了两种次要产物 5 和 6，并提出了形成 3、5 和 6 的机制途径。图形概要
• A New [2+2+1] Heterocyclization for the Synthesis of 2,3,5-Trisubstituted Thiophenes under Microwave Irradiation
  作者：Bo Jiang、Shu-Jiang Tu、Hai-Wei Xu、Guan-Hua Ma

  DOI：10.1055/s-0033-1339917

  日期：——

  Abstract A new three-component strategy for the efficient synthesis of 2,3,5-trisubstituted thiophene derivatives through a [2+2+1] heterocyclization between 3-(2-aryl-2-oxoethylidene)-2-oxindoles and α-thiocyanato ketones under microwave irradiation is described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble thiophene scaffolds. A new three-component

  摘要 通过3-（2-芳基-2-氧代亚乙基）-2-氧吲哚和α-硫氰酸根的[2 + 2 + 1]杂环有效合成2,3,5-三取代噻吩衍生物的新的三组分策略描述了在微波辐射下的酮。这种合成方法的成键效率，可及性和通用性使得组装噻吩支架具有很高的价值。 通过3-（2-芳基-2-氧代亚乙基）-2-氧吲哚和α-硫氰酸根的[2 + 2 + 1]杂环有效合成2,3,5-三取代噻吩衍生物的新的三组分策略描述了在微波辐射下的酮。这种合成方法的成键效率，可及性和通用性使得组装噻吩支架具有很高的价值。
• An Aquatic Pseudo-Four-Component Reaction for the Synthesis of Highly Substituted Thiophenes
  作者：Hassan Zali-Boeini、Maryam Ghani

  DOI：10.1055/s-0032-1316866

  日期：——

  A novel and simple procedure was developed for the construction of fully substituted thiophenes. A series of alpha-haloacetophenone derivatives were converted into fully substituted thiophenes by treatment with sodium sulfide in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene and sodium iodide in aqueous ethanol under aerobic conditions. A mechanism for the reaction is proposed.