2-methyl-N-(2-methylpropyl)propan-1-imine | 6898-82-4

• 物质功能分类: 有机原料 - 氨基化合物
• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-methyl-N-(2-methylpropyl)propan-1-imine
• 英文别名: N-isobutylideneisobutylamine
• CAS: 6898-82-4
• 化学式: C₈H₁₇N
• 分子量: 127.23
• InChiKey: SOJXDJJIMYWISJ-WEVVVXLNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.37
• 重原子数：
  9.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

安全信息

• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  邻碘苯甲酰氯 、 2-methyl-N-(2-methylpropyl)propan-1-imine 在 bis-triphenylphosphine-palladium(II) chloride 、 一氧化碳 、 三乙胺 、 三苯基膦 作用下， 以 乙腈 为溶剂， 100.0 ℃ 、1.01 MPa 条件下， 反应 24.0h， 以59%的产率得到2-isobutyl-3-isopropenyl-1-isoindolinone
  参考文献：
  名称：

  通过钯（0）催化的偶联和2-碘苯甲酰氯与醛亚胺之间的环化反应合成3-烯基异吲哚啉-1-酮

  摘要：

  2-碘苯甲酰氯在催化量的双（三苯基膦）钯（II）与三乙胺的存在下，在一氧化碳下于100°C下与乙胺在乙腈中反应，以高收率得到相应的3-烯基异吲哚啉-1-酮。

  DOI：

  10.1002/jhet.5570350147
• 作为产物：
  描述：

  chloro-diisobutyl-amine 以88%的产率得到
  参考文献：
  名称：

  SCULLY F. E. JR.; DAVIS R. C., J. ORG. CHEM., 1978, 43, NO 7, 1467-1468

  摘要：

  DOI：

文献信息

• Oxidation by persulphate. Part IV. Silver-catalysed oxidation of primary aliphatic amines
  作者：R. G. R. Bacon、D. Stewart

  DOI：10.1039/j39660001384

  日期：——

  Oxidation of a primary aliphatic amine, RCH2·NH2, by aqueous persulphate under alkaline conditions and in the presence of a catalytic amount of silver nitrate, gave the aldimine, RCH:N·CH2R, which was subsequently hydrolysed to the aldehyde, RCHO, and the original amine, or was hydrogenated to the corresponding secondary amine, (RCH2)2NH. The yield of aldehyde varied from 15 to 95% among C3—C9 amines

  在碱性条件下，在催化量的硝酸银存在下，过硫酸盐水溶液氧化伯脂肪族伯胺RCH 2 ·NH 2，得到醛亚胺RCH：N·CH 2 R，随后将其水解为醛，RCHO和原始胺，或被氢化为相应的仲胺（RCH 2）2 NH。在C 3 -C 9胺中，醛的产率在15％至95％之间变化，并且通过在烷基链中分支或通过存在α-苯基来促进转化。在类似条件下，R 1 R 2 CH·NH 2类型的伯胺在不分离酮亚胺的情况下将其转化为酮R 1 R 2 CO。R 1 R 2 R 3 C·NH 2类型的伯胺没有变化。二级反应会使氧化复杂化。
• [EN] BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME<br/>[FR] INHIBITEURS DE BROMODOMAINES BET ET MÉTHODES THÉRAPEUTIQUES LES UTILISANT
  申请人：UNIV MICHIGAN

  公开号：WO2014164596A1

  公开（公告）日：2014-10-09

  Inhibitors of BET bromodomains and compositions containing the same are disclosed. Methods of using the BET bromodomain inhibitors in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, also are disclosed.

  本文披露了BET bromodomain抑制剂及含有它们的组合物。还披露了使用BET bromodomain抑制剂治疗疾病和状况的方法，其中BET bromodomain的抑制提供益处，如癌症等疾病。
• METHOD FOR PURIFYING NITRILE SOLVENT
  申请人：Nippon Soda Co., Ltd.

  公开号：EP3760612A1

  公开（公告）日：2021-01-06

  It is an object of the present invention to provide a method for manufacturing a higher purity nitrile solvent by purifying a nitrile solvent containing an imine, etc., as an impurity. In particular, it is an object to provide a method for manufacturing a higher purity nitrile solvent by purifying a nitrile solvent containing an imine and a conjugated diene, a carbonyl compound, or a high-boiling material as impurities. The present invention is a method for purifying a nitrile solvent, such as isobutyronitrile, comprising bringing a nitrile solvent containing an imine, etc., as an impurity, into contact with an acidic aqueous solution having a pH of 3 or less, such as hydrochloric acid; bringing the nitrile solvent having been contacted with the acidic aqueous solution into contact with an aqueous sodium hydrogen sulfite solution; bringing the nitrile solvent having been contacted with the aqueous sodium hydrogen sulfite solution into contact with an alkaline aqueous solution, such as an aqueous sodium hydroxide solution; and distilling the nitrile solvent having been contacted with the alkaline aqueous solution.

  本发明的目的是提供一种通过提纯含有亚胺等杂质的腈溶剂来制造高纯度腈溶剂的方法。特别是，本发明的目的是提供一种通过提纯含有亚胺和共轭二烯、羰基化合物或高沸点材料作为杂质的腈溶剂来制造更高纯度腈溶剂的方法。本发明是一种提纯腈类溶剂（如异丁腈）的方法，包括将含有亚胺等杂质的腈类溶剂与烯烃、共轭二烯、羰基化合物或高沸点材料接触、使与酸性水溶液接触过的腈溶剂与亚硫酸氢钠水溶液接触；使与亚硫酸氢钠水溶液接触过的腈溶剂与碱性水溶液（如氢氧化钠水溶液）接触；以及蒸馏与碱性水溶液接触过的腈溶剂。
• Boron trifluoride-assisted perfluoroalkylation of carbon-nitrogen double bonds
  作者：Hidemitsu Uno、Shinichiro Okada、Tetsushi Ono、Yasukazu Shiraishi、Hitomi Suzuki

  DOI：10.1021/jo00031a032

  日期：1992.2

  In the presence of BF3.OEt2, (perfluoroalkyl)lithiums generated in situ from the reaction of primary perfluoroalkyl iodides and MeLi-LiBr reacted with imines, azines, and nitrones to afford perfluoroalkylated nitrogen-containing compounds in moderate to good yields. This method was successfully applied to the preparation of a (perfluoroalkyl)glycine and optically active perfluoroalkylated amines.
• MIYAJIMA SHINGO; ITO KUNIO; KASHIWAGURA ISAO; KITAMURA CHOJI, NIXON KAGAKU KAJSI, NIRRON KAGAKU KAISNI, J. CHEM. SOS. JAR., CHEM. AND I+
  作者：MIYAJIMA SHINGO、 ITO KUNIO、 KASHIWAGURA ISAO、 KITAMURA CHOJI

  DOI：——

  日期：——