2-氨基-5,5-二甲基-5,6-二氢-4H-苯并噻唑-7-酮氢溴酸 | 109317-52-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氨基-5,5-二甲基-5,6-二氢-4H-苯并噻唑-7-酮氢溴酸
• 英文名称: 2-Amino-5,5-dimethyl-5,6-dihydrobenzo[d]thiazol-7(4H)-one hydrobromide
• 英文别名: 2-amino-5,5-dimethyl-4,6-dihydro-1,3-benzothiazol-7-one;hydrobromide
• CAS: 109317-52-4
• 化学式: BrH*C₉H₁₂N₂OS
• 分子量: 277.185
• InChiKey: LSQZUGSGHMULRH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.46
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  84.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-氨基-5,5-二甲基-5,6-二氢-4H-苯并噻唑-7-酮氢溴酸 、 potassium carbonate 以70%的产率得到
  参考文献：
  名称：

  UDAPUDI, V. T.;MAHAJANSHETTI, C. S., INDIAN J. CHEM., 25,(1986) N 12, 1269-1272

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴-5,5-二甲基-1,3-环己二酮 、 硫脲 以 四氢呋喃 为溶剂， 反应 36.0h， 以75%的产率得到2-氨基-5,5-二甲基-5,6-二氢-4H-苯并噻唑-7-酮氢溴酸
  参考文献：
  名称：

  Udapudi, V. T.; Mahajanshetti, C. S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1986, vol. 25, p. 1269 - 1272

  摘要：

  DOI：

文献信息

• Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
  申请人：——

  公开号：US20030199501A1

  公开（公告）日：2003-10-23

  The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C 1-6 -alkyl; E is a bond, —CH 2 — or —CO—; L is a bond, —CH 2 —, —CHR 4 — or —NR 3 —; R 3 is H, C 1-6 -alkyl, C 1-6 -acyl or —COR 4 ; R 4 is morpholino or C 1-6 -amido; R 6 and R 7 are independently hydrogen or C 1-6 -alkyl; and R 8 and R 9 are independently hydrogen or C 1-6 -alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.

  本发明涉及使用具有以下化学式（I）的化合物，其中T是（I）噻吩基，它可以用卤素取代，或者（II）苯基，它可以用卤素和/或C1-6烷基取代；E是键，-CH2-或-CO-;L是键，- -，-CHR4-或-NR3-;R3是H，C1-6烷基，C1-6酰基或-COR4;R4是吗啡基或C1-6酰胺基;R6和R7独立地是氢或C1-6烷基;R8和R9独立地是氢或C1-6烷基，以及其药学上可接受的盐，水合物和溶剂化物，在制造用于治疗或预防糖尿病，X综合症，肥胖症，青光眼，高脂血症，高血糖，高胰岛素血症，骨质疏松症，结核病，痴呆症，抑郁症，病毒病和炎症性疾病的药物。
• Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
  申请人：Biovitrum AB

  公开号：US07030135B2

  公开（公告）日：2006-04-18

  The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, —CH2— or —CO—; L is a bond, —CH2—, —CHR4— or —NR3—; R3 is H, C1-6-alkyl, C1-6-acyl or —COR4; R4 is morpholino or C1-6-amido; R6 and R7 are independently hydrogen or C1-6-alkyl; and R8 and R9 are independently hydrogen or C1-6-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.

  本发明涉及使用具有以下式子（I）的化合物，其中T是I）噻吩基，可以用卤素取代，或II）苯基，可以用卤素和/或C1-6烷基取代；E是键，-CH2-或-CO-；L是键，- -，-CHR4-或-NR3-；R3是H，C1-6烷基，C1-6酰基或-COR4；R4是吗啡环或C1-6酰胺基；R6和R7分别是氢或C1-6烷基；R8和R9分别是氢或C1-6烷基，以及其药学上可接受的盐、水合物和溶剂合物，用于制备治疗或预防糖尿病、综合征X、肥胖症、青光眼、高脂血症、高血糖、高胰岛素血症、骨质疏松症、结核病、痴呆症、抑郁症、病毒性疾病和炎症性疾病的药物。
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1283834A1

  公开（公告）日：2003-02-19
• US7030135B2
  申请人：——

  公开号：US7030135B2

  公开（公告）日：2006-04-18
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY-STEROIDE-DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2001090094A1

  公开（公告）日：2001-11-29

  The present invention relates to using a compound having the formula (I) wherein T is I) thienyl, which optionally is substituted with halogen, or II) phenyl optionally substituted with halogen and/or C1-6-alkyl; E is a bond, -CH2- or -CO-; L is a bond, -CH2-, -CHR4- or -NR3-; R3 is H, C¿1-6?-alkyl, C1-6-acyl or -COR?4; R4¿ is morpholino or C¿1-6?-amido; R?6 and R7¿ are independently hydrogen or C¿1-6?-alkyl; and R?8 and R9¿ are independently hydrogen or C¿1-6?-alkyl, as well as pharmaceutically acceptable salts, hydrates and solvates thereof, in the manufacture of a medicament for the treatment or prevention of diabetes, syndrome X, obesity, glaucoma, hyperlipidemia, hyperglycemia, hyperinsulinemia, osteoporosis, tuberculosis, dementia, depression, virus diseases and inflammatory disorders.