2-氨基-8-甲基二苯并[B,F][1,4]氧氮杂-11(10H)-酮 | 23474-59-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-氨基-8-甲基二苯并[B,F][1,4]氧氮杂-11(10H)-酮
• 英文名称: 2-Amino-8-methyl-benz<1,4>oxazepin-11(10 H)on
• 英文别名: 2-amino-8-methyl-10H-dibenzo[b,f][1,4]oxazepin-11-one；2-amino-8-methyldibenzo[b,f][1,4]oxazepin-11(10H)-one；8-amino-3-methyl-5H-benzo[b][1,4]benzoxazepin-6-one
• CAS: 23474-59-1
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: CDUPKIWBASICCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  8-methyl-2-nitro-10H-dibenzo1,4-oxazepin-11-one 在 platinum(IV) oxide 氢气 作用下， 以 甲醇 为溶剂， 生成 2-氨基-8-甲基二苯并[B,F][1,4]氧氮杂-11(10H)-酮
  参考文献：
  名称：

  Nagarajan,K. et al., Indian Journal of Chemistry, 1974, vol. 12, p. 236 - 246

  摘要：

  DOI：

文献信息

• NAGARAJAN K.; VENKATESWARLU A.; KULKARNI C. L.; NAGANA G. A.; SHAH R. K., INDIAN J. CHEM., <IJOC-AP>, 1974, 12, NO 3, 236-246
  作者：NAGARAJAN K.、 VENKATESWARLU A.、 KULKARNI C. L.、 NAGANA G. A.、 SHAH R. K.

  DOI：——

  日期：——
• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• Nagarajan,K. et al., Indian Journal of Chemistry, 1974, vol. 12, p. 236 - 246
  作者：Nagarajan,K. et al.

  DOI：——

  日期：——