3-methoxymethyloxy-5-hydroxybenzyl alcohol | 848474-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-methoxymethyloxy-5-hydroxybenzyl alcohol
• 英文别名: 3-(hydroxymethyl)-5-(methoxymethoxy)phenol
• CAS: 848474-32-8
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: YIZZOWNKLAJTCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-methoxymethyloxy-5-hydroxybenzyl alcohol 在 2,6-二甲基吡啶 、 四溴化碳 、 sodium hydride 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 、 丙酮 、 mineral oil 为溶剂， 反应 12.67h， 生成 (E)-5-(3-(methoxymethoxy)-5-(prop-2-ynyloxy)styryl)benzo[d][1,3]dioxole
  参考文献：
  名称：

  Synthesis and evaluation of water-soluble resveratrol and piceatannol via BGLation

  摘要：

  Synthesis of four water-soluble resveratrol and piceatannol derivatives bearing symmetrically branched glyceryl trimer (BGL003) with a non-biocleavable linkage, and their biological evaluation as a mitochondrial fusion-inducing agent with cellular fat-reducing effect from cells, is described. The effect of Piceatannol-BGL003 conjugate was as high as that of original stilbenoids. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.06.019
• 作为产物：
  描述：

  3,5-二羟基苯甲酸 在 lithium aluminium tetrahydride 、 硫酸 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-methoxymethyloxy-5-hydroxybenzyl alcohol
  参考文献：
  名称：

  Functional Group Diversity in Dendrimers

  摘要：

  [GRAPHIC]A methodology for synthesizing dendrons with different peripheral functionalitles is described. the benzyl ether-based dendrons reported here were synthesized using allyl and methoxymethyl ether-based protection-deprotection strategies.

  DOI：

  10.1021/ol026746e

文献信息

• Receptor Function Regulation Agent
  申请人：Fukatsu Kohji

  公开号：US20080167378A1

  公开（公告）日：2008-07-10

  An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

  提供了一种用于调节14273受体功能的药物代理，可用作预防或治疗糖尿病、高脂血症等疾病。该调节14273受体功能的药物代理包含一种含有芳香环和能释放阳离子的基团的化合物。
• Receptor function regulating agent
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US08008525B2

  公开（公告）日：2011-08-30

  An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

  提供一种调节14273受体功能的药剂，可用作预防或治疗糖尿病、高脂血症或类似疾病的药物。该药剂包括含有芳香环和能释放阳离子的基团的化合物，用于调节14273受体功能的药剂。
• RECEPTOR FUNCTION REGULATING AGENT
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1688138A1

  公开（公告）日：2006-08-09

  An agent for regulating 14273 receptor function, which is useful as a preventing or treating drug for diabetes mellitus, hyperlipidemia or the like, is provided. An agent for regulating 14273 receptor function comprising a compound containing an aromatic ring and a group capable of releasing a cation.

  本发明提供了一种用于调节 14273 受体功能的制剂，该制剂可用作糖尿病、高脂血症或类似疾病的预防或治疗药物。一种用于调节 14273 受体功能的制剂包括一种含有芳香环和能够释放阳离子的基团的化合物。
• EP1688138
  申请人：——

  公开号：——

  公开（公告）日：——
• Probing Every Layer in Dendrons
  作者：Kulandaivelu Sivanandan、Sivakumar V. Aathimanikandan、Christopher G. Arges、Christopher J. Bardeen、S. Thayumanavan

  DOI：10.1021/ja043356+

  日期：2005.2.1

  Dendrons with a fluorescent probe in a specific location have been synthesized and characterized. Accessibility of guest molecules to each of these layers was then analyzed using an intermolecular photoinduced electron-transfer process. Comparisons of the accessibility among each layer of the dendron and among the generations are provided.