endosulfan sulphate | 1031-07-8

• 物质功能分类: 有机原料 - 无机酸酯
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: endosulfan sulphate
• 英文别名: endosulfan sulfate；β-endosulfan sulfate；Thiodan sulfate；(1R,2S,8R,9S)-1,9,10,11,12,12-hexachloro-4,6-dioxa-5λ6-thiatricyclo[7.2.1.02,8]dodec-10-ene 5,5-dioxide
• CAS: 1031-07-8
• 化学式: C₉H₆Cl₆O₄S
• 分子量: 422.928
• InChiKey: AAPVQEMYVNZIOO-DDYGQXQVSA-N

物化性质

• 熔点：
  147.71°C
• 沸点：
  480.7±45.0 °C(Predicted)
• 密度：
  1.6835 (estimate)
• 闪点：
  -26 °C
• 溶解度：
  DMSO：微溶，甲醇：微溶
• 物理描述：
  Endosulfan sulfate is a water solubility - <1 mg/L at 72°F.
• 蒸汽压力：
  1.0X10-11 mm Hg at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

ADMET

代谢

对大鼠口服或腹腔注射/endothall/硫酸盐/...产生了羟基醚和内酯。

ADMINISTRATION OF THE /ENDOSULFAN/ SULFATE /ORALLY OR IP TO RATS/ ... GAVE RISE TO THE HYDROXYETHER & LACTONE.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在绿色/烟草/叶片中，endo硫酸盐被代谢成endo硫酸盐I，而在晾晒过程中，硫酸盐残留物转化为endo硫酸盐II。假设完整叶片中的硫酸盐转化为endo硫酸盐I的过程受一种酶的调控，这种酶在晾晒过程中丢失。

IN GREEN /TOBACCO/ LEAVES, ENDOSULFAN SULFATE WAS METABOLIZED INTO ENDOSULFAN I, WHILE DURING CURING THE SULFATE RESIDUE WAS CONVERTED TO ENDOSULFAN II. IT IS ASSUMED THAT THE CONVERSION OF THE SULFATE IN THE INTACT LEAF INTO ENDOSULFAN I IS GOVERNED BY AN ENZYME WHICH IS LOST DURING THE CURING PROCESS.

来源:Hazardous Substances Data Bank (HSDB)

代谢

在受温度压力的老鼠口服施用-endosulfan I或II，endosulfan sulfate是组织、器官和粪便中最常恢复的代谢物，而不受温度压力的影响。二醇，α-羟基醚和内酯……在大多数尿液和粪便样本中发现。

IN TEMP STRESSED RATS ORALLY DOSED WITH ENDOSULFAN I OR II, ENDOSULFAN SULFATE WAS THE METABOLITE MOST COMMONLY RECOVERED FROM TISSUES, ORGANS & FECES REGARDLESS OF TEMP STRESS. THE DIOL, ALPHA-HYDROXY ETHER & LACTONE ... WERE FOUND IN MOST URINE & FECES SAMPLES.

来源:Hazardous Substances Data Bank (HSDB)

代谢

... 白色小鼠（BALB/C 品系）被喂食了标记有 (14)C 的恩得硫酸。这两种异构体并未完全从消化道吸收，但与恩得硫酸和二醇一起随粪便排出。在肾脏和肌肉提取物中仅发现了极少量的氧化恩得硫酸，但在血液或脑提取物中并未发现这两种已知的代谢物或恩得硫酸。... 在给药后24小时，在肝脏中检测到了大量的恩得硫酸盐，在肾脏中有微量。 ... 小鼠单次接受了恩得硫酸的剂量。

... WHITE MICE (BALB/C STRAIN) WERE FED (14)C-LABELED ENDOSULFAN. THE TWO ISOMERS WERE NOT COMPLETELY ABSORBED FROM GI TRACT BUT, ALONG WITH ENDOSULFAN SULFATE & DIOL, WERE EXCRETED IN FECES. ONLY A TRACE OF OXIDIZED ENDOSULFAN WAS FOUND IN KIDNEY & MUSCLE EXTRACTS BUT NEITHER OF THE TWO KNOWN METABOLITES NOR ENDOSULFAN WAS FOUND IN BLOOD OR BRAIN EXTRACTS. ... LARGE AMOUNTS OF ENDOSULFAN SULFATE WERE DETECTED IN THE LIVER & TRACES IN THE KIDNEY 24 HR AFTER /MICE/ ... RECEIVED SINGLE DOSES OF ENDOSULFAN.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A4；不可分类为人类致癌物。/氯丹/

A4; Not classifiable as a human carcinogen. /Endosulfan/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 副作用

其他毒物 - 有机氯

Other Poison - Organochlorine

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 解毒与急救

基本治疗：建立专利气道。如有必要，进行吸痰。观察呼吸不足的迹象，如有必要，协助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。预测癫痫发作，减少所有外部刺激，并在必要时进行治疗……对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用生理盐水连续冲洗每只眼睛……不要使用催吐剂。对于误食，如果患者能够吞咽，有强烈的干呕反射，并且不流口水，则用水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释。给予活性炭……/艾氏剂、狄氏剂和相关化合物/

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Adininister oxygen by nonrebreather mask at 10 to 15 L/min. Anticipate seizures, reduce all external stimuli, and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... /Aldrin, dieldrin, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

高级治疗：对于昏迷或不省人事的患者，考虑进行口咽或鼻咽插管以控制气道。监测心率和必要时治疗心律失常...开始静脉输液，使用5%葡萄糖盐水/生理盐水维持静脉通路："保持开放"，最低流速。如果出现低血容量的迹象，使用乳酸钠林格氏液。注意液体过载的迹象。用安定（安定）治疗癫痫...使用丙美卡因氢氯化物协助眼部冲洗... /艾氏剂、狄氏剂和有关化合物/

Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or in severe respiratory distress. Monitor cardiac rhythm and treat arrhythmias if necessary ... Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Treat seizures with diazepam (Valium) ... Use proparacaine hydrochloride to assist eye irrigation ... /Aldrin, dieldrin, and related compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 人类毒性摘录

通常的症状包括头痛、眩晕、神经质、视力模糊、虚弱、恶心、痉挛、腹泻和胸部不适。体征包括出汗、瞳孔缩小、流泪、唾液分泌过多以及其他呼吸道分泌物的增加、呕吐、发绀、视乳头水肿、不受控制的肌肉抽搐随后出现肌肉无力、惊厥、昏迷、反射消失和括约肌控制丧失。最后四种体征仅见于严重病例，但如果治疗及时且积极，并不排除有利的预后。可能出现心律失常、不同程度的心脏传导阻滞和心脏骤停... /有机磷农药/

The usual symptoms include headache, giddiness, nervousness, blurred vision, weakness, nausea, cramps, diarrhea, and discomfort in the chest. Signs include sweating, miosis, tearing, salivation and other excessive respiratory tract secretion, vomiting, cyanosis, papilledema, uncontrollable muscle twitches followed by muscular weakness, convulsions, coma, loss of reflexes, and loss of sphincter control. The last four signs are seen only in severe cases but do not preclude a favorable outcome if treatment is prompt and energetic. Cardiac arrhythmias, various degrees of heart block, and cardiac arrest may occur ... /Organic phosphorus pesticides/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

杀虫剂杀硫磷被施用到牧草作物上，牛群在施药后七天开始放牧。在青贮饲料和只有一头牛的脂肪中发现了杀硫磷硫酸盐残留...在喂食处理过的青贮饲料的奶牛牛奶中没有检测到残留物。

ENDOSULFAN WAS APPLIED TO FORAGE CROPS ON WHICH CATTLE WERE ALLOWED TO GRAZE BEGINNING SEVEN DAYS AFTER APPLICATION. ENDOSULFAN SULFATE WAS FOUND IN THE SILAGE & IN THE FAT OF ONLY ONE ANIMAL. ... NO DETECTABLE RESIDUES WERE FOUND IN THE MILK FROM DAIRY COWS FED THE TREATED SILAGE.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

endo硫酸盐的主要排泄途径是在粪便中。

The principal route of excretion for endosulfan and endosulfan sulfate is in the feces.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险等级：
  6.1(a)
• 危险品标志：
  T+,T,F,Xn,N
• 安全说明：
  S16,S22,S24/25,S29,S33,S36/37,S45,S60,S61,S62,S7,S9
• 危险类别码：
  R28,R50,R53
• WGK Germany：
  3
• 危险品运输编号：
  UN No 281
• 包装等级：
  II
• 危险类别：
  6.1(a)

制备方法与用途

生物活性

Endosulfan sulfate 是杀虫剂硫丹（Endosulfan）的主要代谢物，广泛用于多种农作物。与母体化合物相比，Endosulfan sulfate 更具毒性和持久性。

体外研究

Endosulfan 研究表明，它由两个立体异构体（α 和 β）组成。