(1,4-Dioxa-spiro[4.5]dec-8-yl)-(3-morpholin-4-yl-propyl)-amine | 597559-48-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1,4-Dioxa-spiro[4.5]dec-8-yl)-(3-morpholin-4-yl-propyl)-amine
• 英文别名: N-1,4-Dioxaspiro[4.5]dec-8-yl-4-morpholinepropanamine；N-(3-morpholin-4-ylpropyl)-1,4-dioxaspiro[4.5]decan-8-amine
• CAS: 597559-48-3
• 化学式: C₁₅H₂₈N₂O₃
• 分子量: 284.399
• InChiKey: ALDZGCSNIIUVCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-(3-氨丙基)吗啉 、 1,4-环己二酮单乙二醇缩酮 在 MP-triacetoxyborohydride 、 PS-benzaldehyde 作用下， 以 四氢呋喃 为溶剂， 反应 22.0h， 以77%的产率得到(1,4-Dioxa-spiro[4.5]dec-8-yl)-(3-morpholin-4-yl-propyl)-amine
  参考文献：
  名称：

  Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination

  摘要：

  A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reaction conditions. Streamlined protocols for its application in reductive amination reactions using both primary and secondary amines are described. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(03)01167-5

文献信息

• US7985882B1
  申请人：——

  公开号：US7985882B1

  公开（公告）日：2011-07-26
• Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination
  作者：Sukanta Bhattacharyya、Sunil Rana、Owen W Gooding、Jeff Labadie

  DOI：10.1016/s0040-4039(03)01167-5

  日期：2003.6

  A novel polymer-supported triacetoxyborohydride reagent for reductive amination of aldehydes and ketones is reported. The bound reagent was found to be shelf-stable and provided broad scope and reactivity in reductive amination reactions under mild reaction conditions. Streamlined protocols for its application in reductive amination reactions using both primary and secondary amines are described. (C) 2003 Elsevier Science Ltd. All rights reserved.