5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis[(hydrazidocarbonylmethyl)oxy]-p-tert-butylcalix[4]-arene | 122638-96-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis[(hydrazidocarbonylmethyl)oxy]-p-tert-butylcalix[4]-arene
• 英文别名: de-tert-butyl calix[4]arene-tetrahydrazide；2-[[5,11,17,23-Tetratert-butyl-26,27,28-tris(2-hydrazinyl-2-oxoethoxy)-25-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaenyl]oxy]acetohydrazide
• CAS: 122638-96-4
• 化学式: C₅₂H₇₂N₈O₈
• 分子量: 937.192
• InChiKey: BSIPGXDDXHVCQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  68
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  257
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  3-苯基-L-丙氨酸苄酯 、 5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis[(hydrazidocarbonylmethyl)oxy]-p-tert-butylcalix[4]-arene 在 盐酸 、 sodium nitrite 作用下， 以 溶剂黄146 、 氯仿 为溶剂， 以80%的产率得到5,11,17,23-tetra-tert-butyl-(S,S,S,S)-25,26,27,28-tetrakis<carbonylmethoxy>calix<4>arene
  参考文献：
  名称：

  Alekseeva; Bacherikov; Gren', Russian Journal of General Chemistry, 2000, vol. 70, # 3, p. 490 - 491

  摘要：

  DOI：
• 作为产物：
  描述：

  4-叔丁基杯[4]芳烃-四乙酸乙酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以86.8%的产率得到5,11,17,23-tetra-tert-butyl-25,26,27,28-tetrakis[(hydrazidocarbonylmethyl)oxy]-p-tert-butylcalix[4]-arene
  参考文献：
  名称：

  Syntheses, crystal structures, and electrochemical properties of multi-ferrocenyl resorcinarenes

  摘要：

  Tetraaryl and tetraferrocenyl resorcinarenes 1a-1c have been synthesized by the HCl-catalyzed condensation of resorcinol with aromatic aldehydes or ferrocenecarbaldehyde, which were fully alkylated with ethyl a-chloroacetate to give the activated ethyl resorcinarylacetates 2a-2c. Reaction of 2a-2c with hydrated hydrazine yielded the resorcinarene acylhydrazine derivatives 3a-3c, from which the multi-ferrocenyl functional groups were selectively and efficiently introduced on the upper rim, or on the lower rim, or both on the upper and lower rims of resorcinarenes 4a-4c and calixarenes 4d-4f based upon the condensation reactions of acylhydrazones with ferrocenecarboxaldehyde. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.12.073

文献信息

• Synthesis of acridinyl- and fluorenylidenehydrazido derivatives of p-tert-Butylcalix[4]arene
  作者：E. A. Alekseeva、E. A. Lyakhova、A. S. Karpenko、A. P. Luk’yanenko、A. V. Mazepa、A. I. Gren’

  DOI：10.1134/s1070363207060199

  日期：2007.6

  p-tert-Butylcalix[4]arenes substituted at the lower rim by acetic acid hydrazide residues reacted with methoxy(ethoxy)acridine and fluoren-9-one derivatives to give a series of calixarenes containing N'-fluorenylidene- and N'-acridinylacetohydrazide residues. It was found that modification of the hydrazide moiety does not affect the conformation of the initial macroring and that it can lead in some cases to unsymmetrically substituted calixarenes.
• ——
  作者：E. A. Alekseeva、S. P. Krasnoshchekaya、A. I. Gren'

  DOI：10.1023/a:1015386505286

  日期：——
• Alekseeva; Bacherikov; Gren', Russian Journal of General Chemistry, 2000, vol. 70, # 3, p. 490 - 491
  作者：Alekseeva、Bacherikov、Gren'

  DOI：——

  日期：——
• Syntheses, crystal structures, and electrochemical properties of multi-ferrocenyl resorcinarenes
  作者：Jun Han、Ya Hua Cai、Li Liu、Chao Guo Yan、Qi Li

  DOI：10.1016/j.tet.2006.12.073

  日期：2007.3

  Tetraaryl and tetraferrocenyl resorcinarenes 1a-1c have been synthesized by the HCl-catalyzed condensation of resorcinol with aromatic aldehydes or ferrocenecarbaldehyde, which were fully alkylated with ethyl a-chloroacetate to give the activated ethyl resorcinarylacetates 2a-2c. Reaction of 2a-2c with hydrated hydrazine yielded the resorcinarene acylhydrazine derivatives 3a-3c, from which the multi-ferrocenyl functional groups were selectively and efficiently introduced on the upper rim, or on the lower rim, or both on the upper and lower rims of resorcinarenes 4a-4c and calixarenes 4d-4f based upon the condensation reactions of acylhydrazones with ferrocenecarboxaldehyde. (c) 2007 Elsevier Ltd. All rights reserved.