4'-phenyl-2-methyl-3-(dimethylamino)propiophenone | 73932-73-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4'-phenyl-2-methyl-3-(dimethylamino)propiophenone
• 英文别名: (RS)-1-biphenyl-4-yl-3-dimethylamino-2-methyl-propan-1-one；4-[2"-(N,N-dimethylaminomethyl)-propionyl]-biphenyl；3-(Dimethylamino)-2-methyl-1-(4-phenylphenyl)propan-1-one
• CAS: 73932-73-7
• 化学式: C₁₈H₂₁NO
• 分子量: 267.371
• InChiKey: YARYMNGEWBUCOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4'-phenyl-2-methyl-3-(dimethylamino)propiophenone 生成 Z-3-(1-biphenyl-4-yl-3-dimethylamino-2-methyl-propenyl)-phenol hydrochloride
  参考文献：
  名称：

  Substituted amino compounds and their use as substances having an

  摘要：

  通式（I）##STR1## 的氨基取代化合物被描述，以及制备它们的方法和它们作为药物的用途，特别是作为镇痛剂。

  公开号：

  US06022895A1
• 作为产物：
  描述：

  二甲氨基甲醇 、 4-丙酰联苯 以 乙酸酐 为溶剂， 反应 0.25h， 生成 4'-phenyl-2-methyl-3-(dimethylamino)propiophenone
  参考文献：
  名称：

  Synthesis and anticonvulsant activity of N-(benzoylalkyl)imidazoles and N-(.omega.-phenyl-.omega.-hydroxyalkyl)imidazoles

  摘要：

  A novel series of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles was synthesized and evaluated for anticonvulsant activity in mice against maximal electroshock induced seizures. Some of the compounds showed an activity comparable to or better than phenytoin and phenobarbital. The N-[beta-[4-(beta-phenylethyl)phenyl]-beta-hydroxyethyl]imidazole (38) was selected for further studies; preclinical toxicology and additional efficacy evaluations are in progress. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00138a017

文献信息

• Imidazole derivatives
  申请人：Recordati S.A.

  公开号：US04275071A1

  公开（公告）日：1981-06-23

  Imidazole derivatives of the formula I and pharmaceutically acceptable acid addition salts thereof are provided: ##STR1## In the formula, R.sub.4 1- or 2-naphthyl, optionally substituted with Cl, Br, or I; 1,2,3,4-tetrahydro-6-naphthyl; 3-duryl, optionally 6-substituted by Cl, Br, I, NO.sub.2, CH.sub.3 or benzyl; mesityl, phenyl 2-, 3- or 4-substituted by OH, NH.sub.2, NO.sub.2, CH.sub.3 CONH, phenyl, phenoxy, cyclohexyl, phenylthio, benzylthio, C.sub.1 -C.sub.6 alkyl or C.sub.1 C.sub.6 alkylthio; 4-bibenzylyl; 3,4-dihydroxyphenyl, n=0, 1 or 2 and (a) R=H, alkyl having 1 to 6 carbon atoms or phenyl R.sub.1 =H, alkyl having 1 to 6 carbon atoms or phenyl one of R.sub.2 and R.sub.3 =H the other of R.sub.2 and R.sub.3 =H, OH, benzoyloxy, C.sub.2 -C.sub.7 alkanoyloxy, N-(C.sub.1 -C.sub.6 alkyl)-carbamoyloxy, N,N-[di-(C.sub.1 C.sub.6)alkyl]-carbamoyloxy, but if R.sub.2 =R.sub.3 =H then R=R.sub.1 =H, or (b) R=H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.1 =H, C.sub.1 -C.sub.6 alkyl, phenyl R.sub.2 +R.sub.3 =O, or ##STR2## The compounds of formula I are anti-convulsivants.

  提供公式I的咪唑衍生物及其药用可接受的酸盐：##STR1## 在该公式中，R.sub.4为1-或2-萘基，可选地用Cl、Br或I取代；1,2,3,4-四氢-6-萘基；3-二烯基，可选地用Cl、Br、I、NO.sub.2、CH.sub.3或苄取代；甲苯基、苯基2-、3-或4-取代为OH、NH.sub.2、NO.sub.2、CH.sub.3 CONH、苯基、苯氧基、环己基、苯硫基、苄硫基、C.sub.1 -C.sub.6烷基或C.sub.1 -C.sub.6硫代基；4-联苄基；3,4-二羟基苯基，n=0、1或2以及（a）R=H、具有1至6个碳原子的烷基或苯基R.sub.1=H、具有1至6个碳原子的烷基或苯基R.sub.2和R.sub.3中的一个=H另一个=H、OH、苯甲酰氧基、C.sub.2 -C.sub.7烷酰氧基、N-(C.sub.1 -C.sub.6烷基)-氨基甲酰氧基、N,N-[二-(C.sub.1 -C.sub.6)烷基]-氨基甲酰氧基，但如果R.sub.2=R.sub.3=H，则R=R.sub.1=H，或（b）R=H、C.sub.1 -C.sub.6烷基、苯基R.sub.1=H、C.sub.1 -C.sub.6烷基、苯基R.sub.2+R.sub.3=O，或##STR2## 公式I的化合物为抗抽搐剂。
• Propiophenone derivatives and their preparation and pharmaceutical use
  申请人：MARUHO Co., Ltd.

  公开号：EP0423524A2

  公开（公告）日：1991-04-24

  The present invention relates to compounds represented by the general formula I in which X₁, X₂represent hydrogen, C₁₋₄-alky phenyl, halogen, C₁₋₄-alkoxy or dialkylamino with C₁₋₄-alkyl groups, or X₁ and X₂ together represent phenylene or indane-2,3-diyl, Z₁, Z₂represent hydrogen or hydroxy, or together represent oxygen or -O(CH₂)₂O-, Y₁, Y₂represent hydrogen, C₁₋₃-alkyl or phenyl, Arepresents a group derived from a cyclic amine, and nrepresents 0, 1 or 2, in the form of the free base or in the form of addition salts, preferably pharmaceutically acceptable salts, to methods for their preparation, and to their pharmaceutical use as central muscle relaxants and anticonvulsives.

  本发明涉及通式 I 所代表的化合物 其中 X₁、X₂代表氢、C₁₋₄-烷基苯基、卤素、C₁₋₄-烷氧基或带有C₁₋₄-烷基的二烷基氨基，或者X₁和X₂一起代表亚苯基或茚-2,3-二基、 Z₁、Z₂代表氢或羟基，或共同代表氧或-O(CH₂)₂O-、 Y₁、Y₂代表氢、C₁₋₃-烷基或苯基、 代表由环胺衍生的基团、 和 n 代表 0、1 或 2、 这些化合物以游离碱或加成盐（最好是药学上可接受的盐）的形式存在，其制备方 法以及作为中枢性肌肉松弛剂和抗惊厥药的药用用途也是如此。
• Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen
  申请人：Grünenthal GmbH

  公开号：EP0864559A1

  公开（公告）日：1998-09-16

  Es werden substituierte Aminoverbindungen der allgemeinen Formel (I) ein Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel beschrieben.

  描述了通式 (I) 的取代氨基化合物 描述了它们的制备过程及其作为药物的用途。
• NARDI, D.;TAJANA, A.;LEONARDI, A.;PENNINI, R.;PORTIOLI, F.;MAGISTRETTI, M+, J. MED. CHEM., 1981, 24, N 6, 727-731
  作者：NARDI, D.、TAJANA, A.、LEONARDI, A.、PENNINI, R.、PORTIOLI, F.、MAGISTRETTI, M+

  DOI：——

  日期：——
• US4275071A
  申请人：——

  公开号：US4275071A

  公开（公告）日：1981-06-23