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热门化合物HOT

喹啉
水杨醛
二溴甲烷
谷胱甘肽
L-乳酸
苯巴比妥
辣椒碱
非那明
百草枯
联苯烯

methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate | 1331942-96-1

分子结构分类

有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮

中文名称

——

中文别名

——

英文名称

methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

英文别名

Methyl 2-(4-fluorophenyl)-6-nitro-5-(((trifluoromethyl)sulfonyl)oxy)benzofuran-3-carboxylate；methyl 2-(4-fluorophenyl)-6-nitro-5-(trifluoromethylsulfonyloxy)-1-benzofuran-3-carboxylate

methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate化学式

CAS

1331942-96-1

化学式

C₁₇H₉F₄NO₈S

mdl

——

分子量

463.32

InChiKey

LJLNXZMNSYYDKD-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

561.8±50.0 °C(Predicted)
密度：

1.614±0.06 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

4.5
重原子数：

31
可旋转键数：

5
环数：

3.0
sp3杂化的碳原子比例：

0.12
拓扑面积：

137
氢给体数：

0
氢受体数：

12

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	methyl 2-(4-fluorophenyl)-5-hydroxy-6-nitro-1-benzofuran-3-carboxylate	1331942-95-0	C₁₆H₁₀FNO₆	331.257
——	methyl 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-6-nitro-1-benzofuran-3-carboxylate	1331942-88-1	C₁₉H₁₆FNO₆	373.338
——	methyl 2-(4-fluorophenyl)-5-hydroxy-1-benzofuran-3-carboxylate	691856-96-9	C₁₆H₁₁FO₄	286.259
——	methyl 2-(4-fluorophenyl)-5-[(1-methylethyl)oxy]-1-benzofuran-3-carboxylate	1331942-87-0	C₁₉H₁₇FO₄	328.34

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	methyl 5-cyclopropyl-2-(4-fluorophenyl)-6-nitro-1-benzofuran-3-carboxylate	1331942-97-2	C₁₉H₁₄FNO₅	355.322
——	methyl 6-amino-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxylate	1331942-98-3	C₁₉H₁₆FNO₃	325.339
——	methyl 6-[bis(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxylate	1331942-99-4	C₂₁H₂₀FNO₇S₂	481.523
5-环丙基-2-(4-氟苯基)-6-[(甲基磺酰基)氨基]-1-苯并呋喃-3-羧酸	5-cyclopropyl-2-(4-fluorophenyl)-6-[(methylsulfonyl)amino]-1-benzofuran-3-carboxylic acid	691857-54-2	C₁₉H₁₆FNO₅S	389.404
——	5-cyclopropyl-6-(N-(2-fluoro-4-nitrophenyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423007-47-9	C₂₆H₂₁F₂N₃O₆S	541.532
——	methyl 2-(5-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)-2-nitrophenyl)acetate	1423008-47-2	C₂₉H₂₆FN₃O₈S	595.605
——	6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-N-(2-(benzyloxy)ethyl)-5-cyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378429-45-8	C₄₅H₅₂BFN₂O₈S	810.792
——	N-(2-(benzyloxy)ethyl)-5-cyclopropyl-2-(4-fluorophenyl)-6-(methylsulfonamido)benzofuran-3-carboxamide	1378429-42-5	C₂₈H₂₇FN₂O₅S	522.597
——	6-[({4-bromo-3-(hydroxymethyl)-5-[(trifluoromethyl)oxy]phenyl}methyl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-12-2	C₂₉H₂₅BrF₄N₂O₆S	685.491
——	6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378430-04-6	C₃₆H₄₂BFN₂O₇S	676.614
——	5-cyclopropyl-6-(N-(2-(5-fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-31-9	C₂₉H₂₇BF₂N₂O₆S	580.417
——	((4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yI)methylsulfonamido)phenoxy)methyl)boronic acid	1423007-94-6	C₂₇H₂₆BFN₂O₇S	552.388
——	6-[[2-(5-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)ethyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378428-24-0	C₂₉H₂₇BClFN₂O₆S	596.872
——	6-(N-(2-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)ethyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-18-2	C₂₉H₂₇BClFN₂O₆S	596.872
——	6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-isopropylbenzofuran-3-carboxamide	1378429-41-4	C₃₉H₄₈BFN₂O₇S	718.695
——	6-(N-(3-chloro-4-(2-hydroxy-1,2-oxaborolan-5-yl)phenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423008-34-7	C₂₉H₂₇BClFN₂O₆S	596.872
——	6-[[2-(6-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)ethyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378428-22-8	C₂₉H₂₇BClFN₂O₆S	596.872
——	methyl 2-bromo-5-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}-3-[(trifluoromethyl)oxy]benzoate	1378432-10-0	C₃₀H₂₅BrF₄N₂O₇S	713.501
——	6-(N-(3-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)propyl)methylsulfonamido)-N,5-dicyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378429-95-8	C₃₉H₄₆BFN₂O₇S	716.679
——	N-(2-(benzyloxy)ethyl)-6-(N-(2-(benzyloxymethyl)allyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378429-43-6	C₃₉H₃₉FN₂O₆S	682.813
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)ethyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1378428-09-1	C₂₉H₂₈BFN₂O₆S	562.427
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[{2-[(3S)-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl]ethyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378428-12-6	C₂₉H₂₈BFN₂O₆S	562.427
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[{2-[(3R)-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl]ethyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378428-14-8	C₂₉H₂₈BFN₂O₆S	562.427
——	6-[[2-(4-chloro-1-hydroxy-1,3-dihydro-2,1-benzoxaborol-3-yl)ethyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378428-27-3	C₂₉H₂₇BClFN₂O₆S	596.872
——	6-[(3-(2-bromo-4-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-52-0	C₃₅H₄₁BrClFN₂O₅SSi	764.228
——	6-[[3-(2-bromo-4-chlorophenyl)-3-hydroxypropyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-53-1	C₂₉H₂₇BrClFN₂O₅S	649.965
——	6-(N-(2-(benzyloxymethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378429-17-4	C₃₈H₄₆BFN₂O₇S	704.668
——	((2-chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenoxy)methyl)boronic acid	1423007-97-9	C₂₇H₂₅BClFN₂O₇S	586.833
——	(3-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenethyl)boronic acid	1423008-28-9	C₂₈H₂₈BFN₂O₆S	550.416
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-((methylsulfonyl){3-[(phenylmethyl)oxy]-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]propyl}amino)-1-benzofuran-3-carboxamide	1378428-62-6	C₃₇H₄₄BFN₂O₇S	690.641
——	6-[(3-(2-bromo-5-chlorophenyl)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}propyl)(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-65-5	C₃₅H₄₁BrClFN₂O₅SSi	764.228
——	(2-chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenyl)boronic acid	1423007-27-5	C₂₆H₂₃BClFN₂O₆S	556.807
——	3-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenylboronic acid	1423007-38-8	C₂₆H₂₄BFN₂O₆S	522.362
——	6-[[3-(2-bromo-6-chlorophenyl)-3-hydroxypropyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-80-4	C₂₉H₂₇BrClFN₂O₅S	649.965
——	6-(N-(3-(2-bromo-6-fluorophenyl)-3-(tert-butyldimethylsilyloxy)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-03-4	C₃₅H₄₁BrF₂N₂O₅SSi	747.773
——	(6-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)pyridin-3-yl)boronic acid	1423007-56-0	C₂₅H₂₃BFN₃O₆S	523.35
——	6-(N-(4-(benzyloxy)-3-chlorophenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423007-98-0	C₃₃H₂₈ClFN₂O₅S	619.113
——	6-[[3-(2-bromo-5-chlorophenyl)-3-hydroxypropyl](methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378432-68-8	C₂₉H₂₇BrClFN₂O₅S	649.965
——	methyl 2-bromo-5-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}benzoate	1331944-84-3	C₂₉H₂₆BrFN₂O₆S	629.504
——	dimethyl 2-bromo-5-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}-1,3-benzenedicarboxylate	1378431-58-3	C₃₁H₂₈BrFN₂O₈S	687.54
——	methyl 5-{[[3-(aminocarbonyl)-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-6-yl](methylsulfonyl)amino]methyl}-2-bromo-3-fluorobenzoate	1378432-26-8	C₂₈H₂₃BrF₂N₂O₆S	633.467
——	6-(N-(3-(2-bromo-3-chlorophenyl)-3-(tert-butyldimethylsilyloxy)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378432-24-6	C₃₅H₄₁BrClFN₂O₅SSi	764.228
——	5-cyclopropyl-6-(N-(2-(6-fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-33-1	C₂₉H₂₇BF₂N₂O₆S	580.417
——	(2-chloro-4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenethyl)boronic acid	1423008-15-4	C₂₈H₂₇BClFN₂O₆S	584.861
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)methylsulfonamido)-N-(2-hydroxyethyl)benzofuran-3-carboxamide	1378427-47-4	C₂₅H₂₈BFN₂O₇S	530.382
——	methyl 2-bromo-5-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)methyl)-3-fluorobenzoate	1352877-28-1	C₂₉H₂₅BrF₂N₂O₆S	647.494
——	6-(N-(3-(tert-butyldimethylsilyloxy)-3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378431-87-8	C₄₁H₅₄BFN₂O₇SSi	776.85
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[({3-({[(methyloxy)methyl]oxy}methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-[(trifluoromethyl)oxy]phenyl}methyl)(methylsulfonyl)amino]-1-benzofuran-3-carboxamide	1378432-15-5	C₃₇H₄₁BF₄N₂O₉S	776.611
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((1-hydroxy-7-(trifluoromethyl)-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1378428-11-5	C₂₉H₂₅BF₄N₂O₆S	616.398
——	6-(N-(2-(benzyloxy)but-3-enyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378429-33-4	C₃₁H₃₁FN₂O₅S	562.662
——	6-(N-(3-(2-bromo-6-fluorophenyl)-3-hydroxypropyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-04-5	C₂₉H₂₇BrF₂N₂O₅S	633.511
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[({1-hydroxy-7-[(trifluoromethyl)oxy]-1,3-dihydro-2,1-benzoxaborol-5-yl}methyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378428-17-1	C₂₉H₂₅BF₄N₂O₇S	632.397
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-((methylsulfonyl){3-[(phenylmethyl)oxy]propyl}amino)-1-benzofuran-3-carboxamide	1378428-63-7	C₃₀H₃₁FN₂O₅S	550.651
——	6-(N-(3-(2-bromo-3-chlorophenyl)-3-hydroxypropyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378432-25-7	C₂₉H₂₇BrClFN₂O₅S	649.965
——	6-(N-(4-(2-bromophenyl)-3-(tert-butyldimethylsilyloxy)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378432-94-0	C₃₆H₄₄BrFN₂O₅SSi	743.81
——	4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)-3-fluorophenylboronic acid	1423007-46-8	C₂₆H₂₃BF₂N₂O₆S	540.352
——	6-(N-(3-(2-bromo-5-fluorophenyl)-3-hydroxypropyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-13-6	C₂₉H₂₇BrF₂N₂O₅S	633.511
——	4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)phenylboronic acid	1423007-35-5	C₂₆H₂₄BFN₂O₆S	522.362
——	6-(N-(3-(2-bromo-3-fluorophenyl)-3-hydroxypropyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378432-43-9	C₂₉H₂₇BrF₂N₂O₅S	633.511
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-3,4-dihydro-1H-benzo[c][1,2]oxaborinin-6-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1423008-44-9	C₂₈H₂₆BFN₂O₆S	548.4
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(N-(3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methylsulfonamido)benzofuran-3-carboxamide	1423008-11-0	C₃₃H₃₆BFN₂O₆S	618.534
——	6-(N-(2-(benzyloxymethyl)allyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-isopropylbenzofuran-3-carboxamide	1378429-40-3	C₃₃H₃₅FN₂O₅S	590.716
——	dimethyl 5-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzenedicarboxylate	1378431-59-4	C₃₇H₄₀BFN₂O₁₀S	734.607
——	6-(N-(4-(benzyloxy)-3-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378429-07-2	C₃₈H₄₆BFN₂O₇S	704.668
——	6-(N-(3-(2-bromo-4-fluorophenyl)-3-hydroxypropyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-22-7	C₂₉H₂₇BrF₂N₂O₅S	633.511
——	6-(N-(3-(2-bromo-4-fluorophenyl)-3-(tert-butyldimethylsilyloxy)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-20-5	C₃₅H₄₁BrF₂N₂O₅SSi	747.773
——	6-(N-(2-(benzyloxymethyl)but-3-enyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378429-16-3	C₃₂H₃₃FN₂O₅S	576.689
——	6-(N-(3-(tert-butyldimethylsilyloxy)-4-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378432-95-1	C₄₂H₅₆BFN₂O₇SSi	790.877
——	methyl 2-bromo-4-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}benzoate	1378428-55-7	C₂₉H₂₆BrFN₂O₆S	629.504
——	5-cyclopropyl-6-(N-(2-(4-fluoro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)ethyl)methylsulfonamido)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-30-8	C₂₉H₂₇BF₂N₂O₆S	580.417
——	methyl 5-{[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]methyl}-1-hydroxy-1,3-dihydro-2,1-benzoxaborole-7-carboxylate	1378427-98-5	C₃₀H₂₈BFN₂O₈S	606.436
——	6-(N-(4-(benzyloxy)-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)butyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-99-9	C₃₈H₄₆BFN₂O₇S	704.668
——	6-[{[4-bromo-3-(2-{[(methyloxy)methyl]oxy}ethyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378431-74-3	C₃₁H₃₂BrFN₂O₆S	659.573
——	6-[{[4-bromo-3-(1-{[(methyloxy)methyl]oxy}ethyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1378430-98-8	C₃₁H₃₂BrFN₂O₆S	659.573
——	6-(N-(7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423007-82-2	C₂₇H₂₃BClFN₂O₆S	568.818
——	6-(N-(3-(2-bromo-5-fluorophenyl)-3-(tert-butyldimethylsilyloxy)propyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378433-11-4	C₃₅H₄₁BrF₂N₂O₅SSi	747.773
——	6-(N-(3-(tert-butyldimethylsilyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pentyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378429-23-2	C₃₇H₅₄BFN₂O₇SSi	728.806
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[{[3-(1-{[(methyloxy)methyl]oxy}ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl}(methylsulfonyl)amino]-1-benzofuran-3-carboxamide	1378431-00-5	C₃₇H₄₄BFN₂O₈S	706.64
——	6-(N-(2-(benzyloxymethyl)allyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378430-02-4	C₃₀H₂₉FN₂O₅S	548.635
——	6-(N-((7-chloro-1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1378428-03-5	C₂₈H₂₅BClFN₂O₆S	582.845
——	6-(N-(2-(benzyloxymethyl)allyl)methylsulfonamido)-N,5-dicyclopropyl-2-(4-fluorophenyl)benzofuran-3-carboxamide	1378429-93-6	C₃₃H₃₃FN₂O₅S	588.7
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[[(2-hydroxy-1,2-oxaborinan-5-yl)methyl](methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378427-37-2	C₂₅H₂₈BFN₂O₆S	514.383
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)methylsulfonamido)-N-isopropylbenzofuran-3-carboxamide	1378427-45-2	C₂₆H₃₀BFN₂O₆S	528.409
——	6-[{[4-bromo-3-(hydroxymethyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-1-benzofuran-3-carboxamide	1331944-86-5	C₂₈H₂₆BrFN₂O₅S	601.493
——	N,5-dicyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)methylsulfonamido)benzofuran-3-carboxamide	1378427-57-6	C₂₆H₂₈BFN₂O₆S	526.394
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1423008-00-7	C₂₇H₂₄BFN₂O₆S	534.373
——	4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)-2-fluorophenylboronic acid	1423007-41-3	C₂₆H₂₃BF₂N₂O₆S	540.352
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[{[(3S)-1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl]methyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378427-83-8	C₂₉H₂₈BFN₂O₆S	562.427
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[{[(3R)-1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl]methyl}(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378427-84-9	C₂₉H₂₈BFN₂O₆S	562.427
——	5-cyclopropyl-2-(4-fluorophenyl)-6-[[(1-hydroxy-3-methyl-1,3-dihydro-2,1-benzoxaborol-5-yl)methyl](methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide	1378427-76-9	C₂₉H₂₈BFN₂O₆S	562.427
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborolan-4-yl)methyl)methylsulfonamido)benzofuran-3-carboxamide	1378427-58-7	C₂₃H₂₄BFN₂O₆S	486.329
——	5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)(2-{[(phenylmethyl)oxy]methyl}-2-propen-1-yl)amino]-1-benzofuran-3-carboxamide	1378428-61-5	C₃₁H₃₁FN₂O₅S	562.662
——	5-cyclopropyl-2-(4-fluorophenyl)-N-isopropyl-6-(methylsulfonamido)benzofuran-3-carboxamide	1378429-37-8	C₂₂H₂₃FN₂O₄S	430.5
——	6-[{[4-bromo-3-fluoro-5-({[(methyloxy)methyl]oxy}methyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide	1378432-31-5	C₂₉H₂₇BrF₂N₂O₆S	649.51
——	6-[{[4-bromo-3-fluoro-5-(hydroxymethyl)phenyl]methyl}(methylsulfonyl)amino]-5-cyclopropyl-2-(4-fluorophenyl)-1-benzofuran-3-carboxamide	1378432-29-1	C₂₇H₂₃BrF₂N₂O₅S	605.457
——	(4-(N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-6-yl)methylsulfonamido)-2-(trifluoromethyl)phenyl)boronic acid	1423007-63-9	C₂₇H₂₃BF₄N₂O₆S	590.36
——	6-(N-(3-chloro-4-(2-hydroxy-1,2-oxaborolan-4-yl)phenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423008-25-6	C₂₉H₂₇BClFN₂O₆S	596.872
——	[({3-[{5-cyclopropyl-2-(4-fluorophenyl)-3-[(methylamino)carbonyl]-1-benzofuran-6-yl}(methylsulfonyl)amino]propyl}oxy)methyl]boronic acid	1378427-20-3	C₂₄H₂₈BFN₂O₇S	518.371
——	6-(N-(3-bromophenyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide	1423007-39-9	C₂₆H₂₂BrFN₂O₄S	557.44
——	5-cyclopropyl-2-(4-fluorophenyl)-6-(N-((2-hydroxy-1,2-oxaborinan-4-yl)methyl)methylsulfonamido)-N-methylbenzofuran-3-carboxamide	1378427-34-9	C₂₅H₂₈BFN₂O₆S	514.383

反应信息

作为反应物：

描述：

methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate 在盐酸、 potassium fluoride 、四(三苯基膦)钯、 palladium 10% on activated carbon 、水、氢气、三乙胺、 sodium bromide 、 potassium hydroxide 作用下，以乙醇、二氯甲烷、水、乙酸乙酯、甲苯为溶剂，反应 37.0h，生成 5-环丙基-2-(4-氟苯基)-6-[(甲基磺酰基)氨基]-1-苯并呋喃-3-羧酸

参考文献：

名称：

[EN] THERAPEUTIC METHODS
[FR] PROCÉDÉS THÉRAPEUTIQUES

摘要：

本发明涉及一种治疗丙型肝炎的方法，包括在需要的人体内给予本文描述的II式或IIB式化合物或其药用盐与一种或多种替代丙型肝炎治疗药物的组合治疗

公开号：

WO2013025992A1
作为产物：

描述：

4-氟苯甲酰乙酸甲酯在 4-二甲氨基吡啶、硝酸、三氯化硼、 caesium carbonate 、三乙胺、 zinc(II) chloride 作用下，以 N-甲基吡咯烷酮、甲醇、乙醚、二氯甲烷、氯仿为溶剂，反应 29.83h，生成 methyl 2-(4-fluorophenyl)-6-nitro-5-{[(trifluoromethyl)sulfonyl]oxy}-1-benzofuran-3-carboxylate

参考文献：

名称：

[EN] THERAPEUTIC METHODS
[FR] PROCÉDÉS THÉRAPEUTIQUES

摘要：

本发明涉及一种治疗丙型肝炎的方法，包括在需要的人体内给予本文描述的II式或IIB式化合物或其药用盐与一种或多种替代丙型肝炎治疗药物的组合治疗

公开号：

WO2013025992A1

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文献信息

[EN] COMPOUNDS<br/>[FR] COMPOSÉS

申请人：GLAXO GROUP LTD

公开号：WO2012067663A1

公开（公告）日：2012-05-24

The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.

本发明涉及式(I)的化合物及其盐，包括所述化合物的药物组合物，以及利用这些化合物治疗或预防病毒感染，如HCV感染，以及与此类感染相关的疾病。
[EN] BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTIONS<br/>[FR] COMPOSÉS BENZOFURANES POUR LE TRAITEMENT D'INFECTIONS PAR LE VIRUS DE L'HÉPATITE C

申请人：GLAXO GROUP LTD

公开号：WO2013028371A1

公开（公告）日：2013-02-28

The present invention features compounds of formula (I) and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.

本发明涉及式(I)的化合物及其盐，包括所述化合物的药物组合物，以及在治疗或预防病毒感染（如HCV感染）及与此类感染相关的疾病中使用这些化合物的用途。
Therapeutic Methods

申请人：Walker Jill

公开号：US20140212384A1

公开（公告）日：2014-07-31

The present invention features a method for the treatment of Hepatitis C in a human in need thereof comprising administering a compound of Formulas (II) or (IIB) described herein or a pharmaceutically acceptable salt thereof in combination with one or more alternative Hepatitis C therapeutic agents.

本发明涉及一种治疗丙型肝炎的方法，该方法包括在需要的人体内给予本文所述的II或IIB公式化合物或其药学上可接受的盐，与一种或多种其他丙型肝炎治疗药物联合使用。
Benzofuran compounds for the treatment of hepatitis C virus infections

申请人：Chong Pek Yoke

公开号：US08927593B2

公开（公告）日：2015-01-06

The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.

本发明涉及公式（I）的化合物及其盐，包括含有这些化合物的制药组合物，并且涉及使用这些化合物来治疗或预防病毒感染，例如HCV感染以及与此类感染相关的疾病。
Benzofuran Compounds For The Treatment Of Hepatitis C Virus Infections

申请人：Chong Pek Yoke

公开号：US20130237501A1

公开（公告）日：2013-09-12

The present invention features compounds of formula (I): and salts thereof, pharmaceutical compositions comprising said compounds, and uses of such compounds in treating or preventing viral infections, such as HCV infections, and diseases associated with such infections.

本发明涉及式(I)化合物及其盐，包括该化合物的制药组合物，并且使用该化合物治疗或预防病毒感染，例如HCV感染以及与此类感染相关的疾病。