2-氯-4-甲基-噻唑-5-甲醛 | 289469-54-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-氯-4-甲基-噻唑-5-甲醛
• 英文名称: 2-chloro-4-methyl-5-thiazolecarbaldehyde
• 英文别名: 2-chloro-5-formyl-4-methylthiazole；2-chloro-4-methyl-5-Thiazolecarboxaldehyde；2-chloro-4-methyl-1,3-thiazole-5-carbaldehyde
• CAS: 289469-54-1
• 化学式: C₅H₄ClNOS
• mdl: MFCD18453589
• 分子量: 161.612
• InChiKey: BQAYCEGMJWKEAK-UHFFFAOYSA-N

物化性质

• 沸点：
  291.0±32.0 °C(Predicted)
• 密度：
  1.442±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碳酸胍 、 2-氯-4-甲基-噻唑-5-甲醛 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 5-formyl-2-guanidino-4-methylthiazole
  参考文献：
  名称：

  Pyridine compounds and their pharmaceutical use

  摘要：

  根据所附的规格说明书，本发明的化合物(I)和药用可接受的盐具有强烈的抑制一氧化氮(NO)生成的活性，并且可用于预防或治疗由NOS（一氧化氮合酶）介导的疾病，例如成人的呼吸窘迫综合征、心肌炎、滑膜炎、败血症休克、胰岛素依赖型糖尿病、溃疡性结肠炎、脑梗塞、类风湿性关节炎、骨关节炎、骨质疏松症、系统性红斑狼疮、器官移植排斥反应、哮喘、疼痛、溃疡等人类和动物的疾病。

  公开号：

  US06521643B1
• 作为产物：
  描述：

  2-氯-4-甲基噻唑 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-氯-4-甲基-噻唑-5-甲醛
  参考文献：
  名称：

  Pyridine compounds and their pharmaceutical use

  摘要：

  根据所附的规格说明书，本发明的化合物(I)和药用可接受的盐具有强烈的抑制一氧化氮(NO)生成的活性，并且可用于预防或治疗由NOS（一氧化氮合酶）介导的疾病，例如成人的呼吸窘迫综合征、心肌炎、滑膜炎、败血症休克、胰岛素依赖型糖尿病、溃疡性结肠炎、脑梗塞、类风湿性关节炎、骨关节炎、骨质疏松症、系统性红斑狼疮、器官移植排斥反应、哮喘、疼痛、溃疡等人类和动物的疾病。

  公开号：

  US06521643B1

文献信息

• AZOLE COMPOUNDS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1486490A1

  公开（公告）日：2004-12-15

  The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or -NR2-W-D wherein R2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.

  本发明提供了一种由以下式（I）表示的化合物， 其中R1是氢原子、卤原子、可选择取代的碳氢基团、可选择取代的杂环基团、可选择取代的羟基、可选择取代的硫醇基团或可选择取代的氨基， A是可选择取代的环氨基团或-NR2-W-D，其中R2是氢原子或烷基，W是键或二价的非环烃基团，D是可选择取代的环基团、可选择取代的氨基团或可选择取代的酰基团， B是可选择取代的碳氢基团或可选择取代的杂环基团， X是氧原子、硫原子或可选择取代的氮原子，以及 Y是键或二价的非环烃基团，或其盐，用于预防或治疗糖尿病性神经病变等。
• FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF
  申请人：Sakai Nozomu

  公开号：US20090137595A1

  公开（公告）日：2009-05-28

  The present invention provides a fused heterocyclic derivative having a potent kinase inhibitory activity and use thereof. A compound represented by the formula (I): wherein each symbol is as defined in the specification, except a particular compound, or a salt thereof, and a pharmaceutical agent containing the compound or a prodrug thereof, which is a kinase (VEGFR, VEGFR2, PDGFR, Raf) inhibitor, an angiogenesis inhibitor, an agent for the prophylaxis or treatment of cancer, a cancer growth inhibitor or a cancer metastasis suppressor.

  本发明提供了一种具有强大激酶抑制活性的融合杂环衍生物及其用途。 一种由以下式（I）表示的化合物： 其中除了特定化合物或其盐外，每个符号如规范中定义，以及含有该化合物或其前药的药用剂，该化合物是激酶（VEGFR、VEGFR2、PDGFR、Raf）抑制剂，血管生成抑制剂，用于癌症的预防或治疗的药剂，癌症生长抑制剂或癌症转移抑制剂。
• Azole compounds
  申请人：Sakai Nozomu

  公开号：US20050090534A1

  公开（公告）日：2005-04-28

  The present invention provides a compound represented by the formula (I) wherein R 1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR 2 —W-D wherein R 2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.

  本发明提供了一种化合物，其表示为公式(I)，其中R1是氢原子、卤素原子、可选取代的碳氢基团、可选取代的杂环基团、可选取代的羟基、可选取代的硫醇基或可选取代的氨基；A是可选取代的环状氨基基团或-NR2-W-D，其中R2是氢原子或烷基团，W是键或双价的无环烃基团，D是可选取代的环状基团、可选取代的氨基或可选取代的酰基团；B是可选取代的碳氢基团或可选取代的杂环基团；X是氧原子、硫原子或可选取代的氮原子；Y是键或双价的无环烃基团，或其盐。该化合物对于预防或治疗糖尿病性神经病等方面有用。
• Anthraquinone dye compounds having fibers reactive group
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0355586A2

  公开（公告）日：1990-02-28

  Anthraquinone compounds of the formula, wherein R is hydrogen, alkyl or the like, R1 and R2 are each hydrogen, halogen or sulfo, ℓ is 1 or 2, X is sulfo or the like or -V-A-(W)m-Z, and Y is -V1-A1-U, wherein V and V1 are each -0- or -S-, A and A1 are each a divalent group such as W is -NH- or the like, Z is hydrogen or a fiber reactive group, and U is hydrogen, a fiber reactive group or a fiber reactive group-containing group, provided that at least one of Z and U is or has a fiber reactive group, which is useful for dyeing or printing fiber materials such as cotton to give a dyed or printed product having excellent fastness properties, particularly those such as light fastness and perspiration-lightfastness.

  式中的蒽醌化合物、 其中 R 是氢、烷基或类似物，R1 和 R2 分别是氢、卤素或磺基，ℓ 是 1 或 2，X 是磺基或类似物或 -V-A-(W)m-Z，Y 是 -V1-A1-U，其中 V 和 V1 分别是 -0- 或 -S-，A 和 A1 分别是二价基团，如 W 是 -NH- 或类似物，Z 是氢或纤维活性基团，U 是氢、纤维活性基团或含纤维活性基团的基团，条件是 Z 和 U 中至少有一个是或具有纤维活性基团，这有助于对棉等纤维材料进行染色或印花，使染色或印花产品具有优异的牢度性能，尤其是耐光牢度和耐汗耐光牢度。
• Asymmetric dioxazine compounds and method for dyeing or printing fiber materials using the same
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0472975A2

  公开（公告）日：1992-03-04

  An asymmetric dioxazine compound represented by the following formula (I) in the free acid form: wherein A₁ and A₂ independently of one another are each sulfo, halo, alkyl or alkoxy, W is an unsubstituted or substituted aliphatic or aromatic bridging group, X₁ and X₂ independently of one another are each hydrogen, halo, alkyl, alkoxy or phenoxy, R₁ and R₂ independently of one another are each hydrogen or unsubstituted or substituted alkyl, R₃ and R₄ independently of one another are each hydrogen, halo, alkyl, alkoxy or unsubstituted or substituted amino, Z is a fiber-reactive group, m and n independently of one another are each 0 or 1, provided that m≠n, and ℓ is 1 or 2. This compound is suitable for dyeing and printing cellulose fiber, natural and synthetic polyamide fibers, polyrethane fiber, leather and the like and mixed yarns thereof, to obtain dyed or printed products of a color fast to light, wetness and chlorine with superior build-up and level dyeing properties.

  游离酸形式的下式(I)所代表的不对称二恶嗪化合物： 其中 A₁ 和 A₂ 各自独立地为磺、卤、烷基或烷氧基，W 为未取代或取代的脂族或芳族桥基，X₁ 和 X₂ 各自独立地为氢、卤、烷基、烷氧基或苯氧基、R₁和 R₂ 各自独立地为氢或未取代或取代的烷基，R₃和 R₄ 各自独立地为氢、卤代、烷基、烷氧基或未取代或取代的氨基，Z 为纤维反应基团，m 和 n 各自独立地为 0 或 1，但 m≠n 和 ℓ 为 1 或 2。该化合物适用于纤维素纤维、天然和合成聚酰胺纤维、聚氨酯纤维、皮革等及其混纺纱线的染色和印花，以获得耐光、耐湿和耐氯的染色或印花产品，并具有优异的增染和匀染性能。