2,2-dibutyl-N-(8-quinolyl)-N'-(2-pyridyl)malonamide | 144436-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-dibutyl-N-(8-quinolyl)-N'-(2-pyridyl)malonamide
• 英文别名: 2,2-dibutyl-N-pyridin-2-yl-N'-quinolin-8-ylpropanediamide
• CAS: 144436-25-9
• 化学式: C₂₅H₃₀N₄O₂
• 分子量: 418.539
• InChiKey: SACUDKRJZIPSFE-UHFFFAOYSA-N

物化性质

• 沸点：
  690.5±40.0 °C(Predicted)
• 密度：
  1.186±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  84
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二丁基丙二酸 在 氯化亚砜 、 三乙胺 作用下， 反应 10.0h， 生成 2,2-dibutyl-N-(8-quinolyl)-N'-(2-pyridyl)malonamide
  参考文献：
  名称：

  N-(8-quinolyl)-N'-(2-pyridylmethyl)malonamide derivatives as a novel copper(II) carrier with high efficiency and selectivity for proton-driven uphill transport through liquid membranes

  摘要：

  Several N,N'-disubstituted malonamide derivatives have been designed as a carrier for ion transport. Their ability to transport transition-metal ions through liquid membranes has been investigated. It has been found that N-(8-quinolyl)-N'-(2-pyridylmethyl)malonamide derivatives can transport Cu(II) with high efficiency and selectivity against its concentration gradient from nearly a neutral aqueous phase (pH 6.2) to an acidic aqueous phase through a chloroform liquid membrane.

  DOI：

  10.1021/jo00052a019

文献信息

• N-(8-quinolyl)-N'-(2-pyridylmethyl)malonamide derivatives as a novel copper(II) carrier with high efficiency and selectivity for proton-driven uphill transport through liquid membranes
  作者：Kazuhisa Hiratani、Takuji Hirose、Kazuyuki Kasuga、Kiyoshi Saito

  DOI：10.1021/jo00052a019

  日期：1992.12

  Several N,N'-disubstituted malonamide derivatives have been designed as a carrier for ion transport. Their ability to transport transition-metal ions through liquid membranes has been investigated. It has been found that N-(8-quinolyl)-N'-(2-pyridylmethyl)malonamide derivatives can transport Cu(II) with high efficiency and selectivity against its concentration gradient from nearly a neutral aqueous phase (pH 6.2) to an acidic aqueous phase through a chloroform liquid membrane.