(2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(2,5-diphenylphosphol-1-yl)butane | 134386-12-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(2,5-diphenylphosphol-1-yl)butane
• 英文别名: (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(2,5-diphenylphosphol-1-yl)butane；(4R,5R)-4,5-bis[(2,5-diphenylphosphol-1-yl)methyl]-2,2-dimethyl-1,3-dioxolane
• CAS: 134386-12-2
• 化学式: C₃₉H₃₆O₂P₂
• 分子量: 598.661
• InChiKey: HNFDUDDTOGQCKU-HEVIKAOCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  di-μ-chloro-bis(1,5-cyclooctadiene)dirhodium 、 (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(2,5-diphenylphosphol-1-yl)butane 以 丙酮 为溶剂， 以99%的产率得到
  参考文献：
  名称：

  Chiral diphospholes

  摘要：

  An improved, 90% yield synthesis of the chiral diphosphole, (R,R)-DIPPOP (1) is reported. The reactions of 1 with nickel, palladium, platinum and rhodium complexes are examined. 1 does not react with NiCl2. With PdCl2 and PtCl2, it forms various cis and trans diphosphine-bridged cyclooligomers of undetermined ring size. The rhodium complexes [Rh(cod)(2)]BF4, [Rh(acac)(cod)] and {Rh(mu-Cl)(cod)}(2) are good precursors for the synthesis of [Rh(cod){(R,R)-DIPPOP}]BF4, (8), [Rh(acac){(R,R)-DIPPOP}], (9), and {Rh(cod)Cl}(2){mu-P,P'-(R,R)-DIPPOP}, (10), which are fully characterized by multinuclear NMR spectroscopy.

  DOI：

  10.1016/0022-328x(93)83419-v
• 作为产物：
  描述：

  1,2,5-triphenyl-1H-phosphole 、 (-)-1,4-二-O-甲苯磺酰基-2,3-O-异亚丙基-L-苏糖醇 在 氯代叔丁烷 、 lithium 作用下， 生成 (2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis-(2,5-diphenylphosphol-1-yl)butane
  参考文献：
  名称：

  Chiral diphospholes

  摘要：

  An improved, 90% yield synthesis of the chiral diphosphole, (R,R)-DIPPOP (1) is reported. The reactions of 1 with nickel, palladium, platinum and rhodium complexes are examined. 1 does not react with NiCl2. With PdCl2 and PtCl2, it forms various cis and trans diphosphine-bridged cyclooligomers of undetermined ring size. The rhodium complexes [Rh(cod)(2)]BF4, [Rh(acac)(cod)] and {Rh(mu-Cl)(cod)}(2) are good precursors for the synthesis of [Rh(cod){(R,R)-DIPPOP}]BF4, (8), [Rh(acac){(R,R)-DIPPOP}], (9), and {Rh(cod)Cl}(2){mu-P,P'-(R,R)-DIPPOP}, (10), which are fully characterized by multinuclear NMR spectroscopy.

  DOI：

  10.1016/0022-328x(93)83419-v

文献信息

• HAJOUJI, HASSANE;NEIBECKER, DENIS;REAU, REGIS, C. R. ACAD. SCI. SER. 2, 312,(1991) N, C. 229-234
  作者：HAJOUJI, HASSANE、NEIBECKER, DENIS、REAU, REGIS

  DOI：——

  日期：——
• Chiral diphospholes
  作者：Jean-Jacques Brunet、Montserrat Gómez、Hassane Hajouji、Denis Neibecker

  DOI：10.1016/0022-328x(93)83419-v

  日期：1993.12

  An improved, 90% yield synthesis of the chiral diphosphole, (R,R)-DIPPOP (1) is reported. The reactions of 1 with nickel, palladium, platinum and rhodium complexes are examined. 1 does not react with NiCl2. With PdCl2 and PtCl2, it forms various cis and trans diphosphine-bridged cyclooligomers of undetermined ring size. The rhodium complexes [Rh(cod)(2)]BF4, [Rh(acac)(cod)] and Rh(mu-Cl)(cod)}(2) are good precursors for the synthesis of [Rh(cod)(R,R)-DIPPOP}]BF4, (8), [Rh(acac)(R,R)-DIPPOP}], (9), and Rh(cod)Cl}(2)mu-P,P'-(R,R)-DIPPOP}, (10), which are fully characterized by multinuclear NMR spectroscopy.