5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol | 1360068-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol
• 英文别名: 5-[[Bis(pyridin-2-ylmethyl)amino]methyl]quinolin-8-ol；5-[[bis(pyridin-2-ylmethyl)amino]methyl]quinolin-8-ol
• CAS: 1360068-02-5
• 化学式: C₂₂H₂₀N₄O
• 分子量: 356.427
• InChiKey: ZLTJIUKCOZGDEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  62.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  5-(氯甲基)-8-羟基喹啉盐酸盐 、 二甲基吡啶胺 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以1.3 g的产率得到5-((bis(pyridin-2-ylmethyl)amino)methyl)quinolin-8-ol
  参考文献：
  名称：

  A novel ditopic ligand derived from 8-hydroxyquinoline: Synthesis, characterisation, and its coordination chemistry with selected metal ions

  摘要：

  A novel multidentate ligand, 5-(bis(pyridin-2-ylmethyl)amino)quinolin-8-ol (HL) was synthesised and characterised. Its coordination modes with a variety of metal ions (Mg2+, Co2+, Cu2+, Zn2+, and Hg2+) were investigated using UV-Vis spectroscopic titration. Among the examined metal ions, coordination ratios (M2+: HL) between the metal ion and the ligand at 1: 2, 1: 1, and 3: 2 were observed due to the ditopic nature of the ligand. In acetonitrile, Mg2+ showed relatively strong fluorescent response upon binding to the ligand among the examined metal ions, Li+, K+, Mg2+, Ca2+, Al3+, Cu2+, Fe3+, Cr3+, Zn2+, Co2+, Ni2+, and Hg2+. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.061

文献信息

• A novel ditopic ligand derived from 8-hydroxyquinoline: Synthesis, characterisation, and its coordination chemistry with selected metal ions
  作者：Xiang Xie、Xiujuan Jiang、Jian Liu、Xingye Ren、Hongming Wang、Xiaoming Liu

  DOI：10.1016/j.ica.2011.10.061

  日期：2012.3

  A novel multidentate ligand, 5-(bis(pyridin-2-ylmethyl)amino)quinolin-8-ol (HL) was synthesised and characterised. Its coordination modes with a variety of metal ions (Mg2+, Co2+, Cu2+, Zn2+, and Hg2+) were investigated using UV-Vis spectroscopic titration. Among the examined metal ions, coordination ratios (M2+: HL) between the metal ion and the ligand at 1: 2, 1: 1, and 3: 2 were observed due to the ditopic nature of the ligand. In acetonitrile, Mg2+ showed relatively strong fluorescent response upon binding to the ligand among the examined metal ions, Li+, K+, Mg2+, Ca2+, Al3+, Cu2+, Fe3+, Cr3+, Zn2+, Co2+, Ni2+, and Hg2+. (C) 2011 Elsevier B. V. All rights reserved.