3-methoxy-2,4,5-trimethylaniline | 182011-42-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-methoxy-2,4,5-trimethylaniline
• CAS: 182011-42-3
• 化学式: C₁₀H₁₅NO
• 分子量: 165.235
• InChiKey: LYDGWICKEZDZKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxy-2,4,5-trimethylaniline 在 N-溴代丁二酰亚胺(NBS) 、 叔丁基锂 、 对甲苯磺酸 、 三甲基乙酸 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.33h， 生成 methyl (E)-6-(2-amino-3-bromo-6-methoxy-4,5-dimethylphenyl)-4-methylhex-4-enoate
  参考文献：
  名称：

  Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid

  摘要：

  Structure-activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored. Replacement of the lactone ring with other cyclic moieties resulted in loss of potency, especially for larger groups. Replacement of the ring by acyclic substituents also indicated a strong sensitivity to steric bulk. A phenolic hydroxyl group, with an adjacent hydrogen bond acceptor, was found to be essential for high potency. The aromatic methyl group was essential for activity; the methoxyl group could be replaced by ethyl to give a compound with 2-4 times the potency of mycophenolic acid in vitro and in vivo.

  DOI：

  10.1021/jm9603633
• 作为产物：
  描述：

  1-Bromo-4-methoxy-2,3,5-trimethyl-6-nitrobenzene 在 palladium on activated charcoal 氢气 、 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 3-methoxy-2,4,5-trimethylaniline
  参考文献：
  名称：

  Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid

  摘要：

  Structure-activity relationships in the region of the phthalide ring of the inosine monophosphate dehydrogenase inhibitor mycophenolic acid have been explored. Replacement of the lactone ring with other cyclic moieties resulted in loss of potency, especially for larger groups. Replacement of the ring by acyclic substituents also indicated a strong sensitivity to steric bulk. A phenolic hydroxyl group, with an adjacent hydrogen bond acceptor, was found to be essential for high potency. The aromatic methyl group was essential for activity; the methoxyl group could be replaced by ethyl to give a compound with 2-4 times the potency of mycophenolic acid in vitro and in vivo.

  DOI：

  10.1021/jm9603633

文献信息

• ACRYLIC RUBBER COMPOSITION
  申请人：DENKI KAGAKU KOGYO KABUSHIKI KAISHA

  公开号：EP1449881A1

  公开（公告）日：2004-08-25

  To provide an acrylic rubber composition having a satisfactory vulcanizability and excellent in a balance between processability and compression set. An acrylic rubber composition excellent in processability and compression set, which can be obtained by combining (A) a carboxyl group-containing acrylic elastomer, (B) at least one monoamine compound selected from the group consisting of a primary amine, a secondary amine and a tertiary amine, (C) a guanidine type compound, and (D) a specific diamine compound.

  提供一种丙烯酸橡胶组合物，该组合物具有令人满意的硫化性，并且在加工性和压缩永久变形之间具有优异的平衡性。 一种加工性和压缩永久变形性能优异的丙烯酸橡胶组合物，可通过将 (A) 含羧基的丙烯酸弹性体、(B) 至少一种选自伯胺、仲胺和叔胺的单胺化合物、(C) 一种胍类化合物和 (D) 一种特定二胺化合物混合使用而获得。
• POLYIMIDE PRECURSOR COMPOSITION
  申请人：Tokyo Ohka Kogyo Co., Ltd.

  公开号：EP3330320A1

  公开（公告）日：2018-06-06

  Provided are: a polyimide precursor composition that exhibits excellent tensile strength and breaking elongation, and that provides a film containing an alicyclic polyimide resin; a method for producing a polyimide film using the polyimide precursor composition; and a permanent film that contains an alicyclic polyimide resin and that exhibits excellent tensile strength and breaking elongation. The polyimide precursor composition that is used is a mixture of: a resin precursor component (B) selected from a polyamic acid including an alicyclic backbone having a predetermined structure, and a monomer component that includes an aromatic diamine compound having a predetermined structure and an alicyclic tetracarboxylic acid di-anhydride having a predetermined structure; an imidazole compound (A) having a predetermined structure; and a solvent (S).

  本发明提供了：一种聚酰亚胺前体组合物，该组合物具有优异的拉伸强度和断裂伸长率，并提供一种含有脂环族聚酰亚胺树脂的薄膜；一种使用该聚酰亚胺前体组合物生产聚酰亚胺薄膜的方法；以及一种含有脂环族聚酰亚胺树脂且具有优异的拉伸强度和断裂伸长率的永久性薄膜。使用的聚酰亚胺前体组合物是以下物质的混合物：选自包括具有预定结构的脂环族骨架的聚酰胺酸的树脂前体组分（B），以及包括具有预定结构的芳香族二胺化合物和具有预定结构的脂环族四羧酸二酐的单体组分；具有预定结构的咪唑化合物（A）；以及溶剂（S）。
• Polyimide precursor composition
  申请人：TOKYO OHKA KOGYO CO., LTD.

  公开号：US10954340B2

  公开（公告）日：2021-03-23

  A polyimide precursor composition that exhibits excellent tensile strength and breaking elongation, and that provides a film containing an alicyclic polyimide resin; a method for producing a polyimide film using the polyimide precursor composition; and a permanent film that contains an alicyclic polyimide resin and that exhibits excellent tensile strength and breaking elongation. The polyimide precursor composition is a mixture of a resin precursor component which is a polyamic acid including an alicyclic backbone having a predetermined structure, a monomer component that includes an aromatic diamine compound having a predetermined structure or an alicyclic tetracarboxylic acid di-anhydride having a predetermined structure; an imidazole compound having a predetermined structure; and a solvent.

  一种聚酰亚胺前体组合物，该组合物具有优异的拉伸强度和断裂伸长率，并提供一种含有脂环族聚酰亚胺树脂的薄膜；一种使用该聚酰亚胺前体组合物生产聚酰亚胺薄膜的方法；以及一种含有脂环族聚酰亚胺树脂并具有优异的拉伸强度和断裂伸长率的永久性薄膜。聚酰亚胺前体组合物是一种树脂前体组分的混合物，该组分是一种聚酰胺酸，包括具有预定结构的脂环族骨架；一种单体组分，包括具有预定结构的芳香族二胺化合物或具有预定结构的脂环族四羧酸二酐；一种具有预定结构的咪唑化合物；以及一种溶剂。
• Ethylene-acrylic copolymer rubber composition
  申请人：Denki Kagaku Kogyo Kabushiki Kaisha

  公开号：US20040266922A1

  公开（公告）日：2004-12-30

  An ethylene-acrylic copolymer rubber composition, which comprises (A) a carboxyl group-containing ethylene-acrylic copolymer rubber, (B) at least one monoamine compound selected from the group consisting of a primary amine, a secondary amine and a tertiary amine, (C) a guanidine type compound, and (D) at least one of an aromatic diamine compound expressed by the following structural formula (1), H 2 N—Ph-M-Ph—NH 2 structural formula (1): wherein M is O, S, SO 2 , CONH, or O—R—O in which R is Ph, Ph—Ph, Ph—SO 2 —Ph, (CH 2 ) m , (CH 2 )C(CH 3 ) 2 (CH 2 ), or Ph—C(CX 3 ) 2 —Ph, and m=3-5, X═H or F and Ph=benzene ring.

  一种乙烯-丙烯酸共聚物橡胶组合物，它包括(A)含羧基的乙烯-丙烯酸共聚物橡胶，(B)至少一种从伯胺、仲胺和叔胺组成的组中选出的单胺化合物，(C)一种胍类化合物，以及(D)至少一种由以下结构式(1)、H 2 N-Ph-M-Ph-NH 2 结构式(1)表示的芳香族二胺化合物： 其中 M 为 O、S、SO 2、CONH 或 O-R-O，其中 R 为 Ph、Ph-Ph、Ph-SO 2-Ph、(CH 2 ) m、(CH 2 )C(CH 3 ) 2 (CH 2 )或 Ph-C(CX 3 ) 2-Ph，且 m=3-5, X═H 或 F 和 Ph=benzene ring。
• POST-TREATED SULFURIZED SALT OF AN ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOSITION
  申请人：Chevron Oronite Company LLC

  公开号：EP2798050B1

  公开（公告）日：2020-04-22