dimethyl 2-(3,3-dimethoxypropyl)-1,3-propanedioate | 53744-52-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: dimethyl 2-(3,3-dimethoxypropyl)-1,3-propanedioate
• 英文别名: dimethyl 3,3-dimethoxypropylmalonate；(3,3-dimethoxy-propyl)-malonic acid dimethyl ester；Dimethyl (3,3-dimethoxypropyl)propanedioate；dimethyl 2-(3,3-dimethoxypropyl)propanedioate
• CAS: 53744-52-8
• 化学式: C₁₀H₁₈O₆
• 分子量: 234.249
• InChiKey: ZNYLOOSOMNJROS-UHFFFAOYSA-N

物化性质

• 沸点：
  271.5±40.0 °C(Predicted)
• 密度：
  1.094±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl 2-(3,3-dimethoxypropyl)-1,3-propanedioate 在 sodium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 5,5-二甲氧基戊酸甲酯
  参考文献：
  名称：

  Stereochemistry of the Robinson-Schoepf reaction. A stereospecific total synthesis of the ladybug defense alkaloids precoccinelline and coccinelline

  摘要：

  DOI：

  10.1021/ja00517a042
• 作为产物：
  描述：

  丙二酸二甲酯 在 sodium 、 对甲苯磺酸 作用下， 以 甲醇 为溶剂， 生成 dimethyl 2-(3,3-dimethoxypropyl)-1,3-propanedioate
  参考文献：
  名称：

  Stereochemistry of the Robinson-Schoepf reaction. A stereospecific total synthesis of the ladybug defense alkaloids precoccinelline and coccinelline

  摘要：

  DOI：

  10.1021/ja00517a042

文献信息

• Palladium-Catalyzed Asymmetric Synthesis of Axially Chiral Allenylsilanes and Their Application to S_E2′ Chirality Transfer Reactions
  作者：Masamichi Ogasawara、Atsushi Okada、Velusamy Subbarayan、Sebastian Sörgel、Tamotsu Takahashi

  DOI：10.1021/ol102554a

  日期：2010.12.17

  desilylative SE2′ reaction to the ambivalent 2-bromo-1-silyl-1,3-dienes provides a novel route to the highly enantioselective construction of tertiary and quaternary propargylic stereogenic centers via axially chiral allenylsilanes.

  将Pd催化的S N 2'反应和脱甲硅烷基化的S E 2'反应逐步应用到矛盾的2-溴-1-甲硅烷基-1,3-二烯上，为叔和季炔丙基的高对映选择性构建提供了一条新途径通过轴向手性烯基硅烷形成立体中心。
• Catalytic Asymmetric Arylative Cyclization of Alkynals:  Phosphine-Free Rhodium/Diene Complexes as Efficient Catalysts
  作者：Ryo Shintani、Kazuhiro Okamoto、Yusuke Otomaru、Kazuhito Ueyama、Tamio Hayashi

  DOI：10.1021/ja044021v

  日期：2005.1.1

  Catalytic arylative cyclization of alkynals has been developed by the use of phosphine-free rhodium/diene complexes as catalysts. An asymmetric variant of this process has been successfully realized by employing a C2-symmetric chiral bicyclo[2.2.2]octadiene ligand. The rhodium/diene catalyst system is also effective for arylative cyclization of other substrates such as alkynones and enynes, achieving multiple

  通过使用不含膦的铑/二烯配合物作为催化剂，已经开发了炔醇的催化芳基化环化。通过使用 C2 对称手性双环 [2.2.2] 辛二烯配体，该过程的不对称变体已成功实现。铑/二烯催化剂体系对于炔酮和烯炔等其他底物的芳基化环化也很有效，在一个步骤中实现多个碳-碳键的形成。
• Substituted Tetrahydroquinolines
  申请人：Schiemann Kai

  公开号：US20080194615A1

  公开（公告）日：2008-08-14

  Disclosed are compounds of formula (I), wherein W, R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 have the meanings indicated in claim 1 . Said compounds can be used for the treatment of tumors, among other things.

  本发明揭示了式(I)的化合物，其中W、R、R1、R2、R3、R4、R5、R6和R7具有权利要求书中所示的含义。该化合物可用于肿瘤治疗等方面。
• Synthesis and ring-opening polymerization of bicyclic lactones
  申请人：University Patents, Inc.

  公开号：US04677190A1

  公开（公告）日：1987-06-30

  The synthesis of novel strained bicyclic lactones and their ring-opening polymerization to high molecular weight polyester polymers is disclosed.

  本文揭示了新型应变双环内酯的合成及其开环聚合到高分子量聚酯聚合物的过程。
• Unusual Transposition of Allenic Framework in Intramolecular Cyclization of Acetal-Tethered (Allenylmethyl)silanes
  作者：Masamichi Ogasawara、Atsushi Okada、Hidetoshi Murakami、Susumu Watanabe、Yonghui Ge、Tamotsu Takahashi

  DOI：10.1021/ol901780d

  日期：2009.9.17

  Treatment of acetal-tethered (allenylmethyl)silanes, which were obtained from the corresponding 3-bromo-5-silyl-1,3-pentadienes by a Pd-catalyzed reaction with an acetal-tethered malonate, with TiCl4 gave not only vinylcyclohexene derivatives via a standard S(E)2' pathway but also unusual allenylcyclopentane species via cyclization at the delta-position. Deuterium-labeling experiments revealed participation of a 1,2-hydride shift in a carbocation intermediate for the formation of the latter products.